A single post‐exposure oxime RS194B treatment rapidly reactivates acetylcholinesterase and reverses acute symptoms in macaques exposed to diethylphosphorothioate parathion and chlorpyrifos insecticides - Rosenberg, Yvonne J.; Garcia, Kelly; Diener, Justin; Sullivan, Dennis; Donahue, Scott; Mao, Lingjun; Lees, Jonathan; Jiang, Xiaoming; Urban, Lori A.; Momper, Jeremiah D.; Ho, Kwok‐Yiu; Taylor, Palmer (Journal of neurochemistry, 2024)
Keywords: Acetamides; Acetylcholinesterase; Acetylcholinesterase - chemistry; Animal models; Animals; Antidotes; Atropine; Blood circulation; Blood-brain barrier; Butyrylcholinesterase - chemistry; Chlorpyrifos; Chlorpyrifos - toxicity; Cholinergic nerves; Cholinergics; Cholinesterase Inhibitors - chemistry; Cholinesterase Reactivators - chemistry; Cholinesterase Reactivators - pharmacology; Clinical trials; diethylphosphorothioate insecticides AChE reactivation; Effectiveness; Exposure; Insecticides; Insecticides - toxicity; Macaca; macaques; Mice; Nerve Agents; Nerves; Nervous system; Neurotoxins; Organophosphates; Organophosphorus Compounds - toxicity; oxime antidote; Oximes; Oximes - chemistry; Oximes - pharmacology; Oximes - therapeutic use; Paraoxon; Parathion; Parathion - adverse effects; Parathion - toxicity; Pesticides; post‐exposure; Preventable deaths; Sarin; survival; Synapses; Toxins; post‐exposure; diethylphosphorothioate insecticides AChE reactivation; oxime antidote; macaques; survival