Breg Cells Are Numerically Decreased and Functionally Impaired in Patients With Systemic Sclerosis

• Published in: Arthritis & rheumatology (Hoboken, N.J.) Vol. 68; no. 2; pp. 494 - 504
• Main Authors: Mavropoulos, Athanasios, Simopoulou, Theodora, Varna, Areti, Liaskos, Christos, Katsiari, Christina G., Bogdanos, Dimitrios P., Sakkas, Lazaros I.
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.02.2016
• Subjects: ADP-ribosyl Cyclase 1 - immunology; Adult; Aged; Antigens, CD19 - immunology; Arthritis, Rheumatoid - complications; Arthritis, Rheumatoid - immunology; B-Lymphocytes, Regulatory - immunology; Case-Control Studies; CD24 Antigen - immunology; Female; Flow Cytometry; Humans; Interleukin-10 - immunology; Lymphocyte Activation; Lymphocyte Count; Male; Middle Aged; p38 Mitogen-Activated Protein Kinases - immunology; Pulmonary Fibrosis - etiology; Pulmonary Fibrosis - immunology; Receptors, Antigen, B-Cell; Scleroderma, Systemic - complications; Scleroderma, Systemic - immunology; Severity of Illness Index; STAT3 Transcription Factor - immunology; Toll-Like Receptor 9; Tumor Necrosis Factor Receptor Superfamily, Member 7 - immunology

Objective Breg cells, a regulatory cell subset that produces interleukin‐10 (IL‐10), play a significant role in suppressing autoimmune responses and preventing autoimmunity. This study was undertaken to examine the number and function of Breg cells in patients with systemic sclerosis (SSc), a diseas...