Intracellular Staphylococcus aureus and host cell death pathways

Staphylococcus aureus is a major opportunistic human pathogen that is globally prevalent. Although S. aureus and humans may have co‐evolved to the point of commensalism, the bacterium is equipped with virulence factors causing devastating infections. The adoption of an intracellular lifestyle by S....

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Published inCellular microbiology Vol. 23; no. 5; pp. e13317 - n/a
Main Authors Soe, Ye Mon, Bedoui, Sammy, Stinear, Timothy P., Hachani, Abderrahman
Format Journal Article
LanguageEnglish
Published Chichester, UK John Wiley & Sons, Inc 01.05.2021
Subjects
Antibiotics
Apoptosis
Autophagy
Cell death
Commensalism
ferroptosis
Intracellular
intracellular pathogen
Localization
metabolism
Necroptosis
Opportunist infection
Pathogenesis
PCD
Penicillin
Phagocytosis
programmed cell death
Pyroptosis
Staphylococcus aureus
Virulence
Virulence factors
PCD
pyroptosis
autophagy
ferroptosis
intracellular pathogen
apoptosis
metabolism
programmed cell death
Staphylococcus aureus
necroptosis
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Abstract Staphylococcus aureus is a major opportunistic human pathogen that is globally prevalent. Although S. aureus and humans may have co‐evolved to the point of commensalism, the bacterium is equipped with virulence factors causing devastating infections. The adoption of an intracellular lifestyle by S. aureus is an important facet of its pathogenesis. Occupying a privileged intracellular compartment permits evasion from the bactericidal actions of host immunity and antibiotics. However, this localization exposes S. aureus to cell‐intrinsic processes comprising autophagy, metabolic challenges and clearance mechanisms orchestrated by host programmed cell death pathways (PCDs), including apoptosis, pyroptosis and necroptosis. Mounting evidence suggests that S. aureus deploys pathoadaptive mechanisms that modulate the expression of its virulence factors to prevent elimination through PCD pathways. In this review, we critically analyse the current literature on the interplay between S. aureus virulence factors with the key, intertwined nodes of PCD. We discuss how S. aureus adaptation to the human host plays an essential role in the evasion of PCD, and we consider future directions to study S. aureus–PCD interactions.
AbstractList Staphylococcus aureus is a major opportunistic human pathogen that is globally prevalent. Although S. aureus and humans may have co-evolved to the point of commensalism, the bacterium is equipped with virulence factors causing devastating infections. The adoption of an intracellular lifestyle by S. aureus is an important facet of its pathogenesis. Occupying a privileged intracellular compartment permits evasion from the bactericidal actions of host immunity and antibiotics. However, this localization exposes S. aureus to cell-intrinsic processes comprising autophagy, metabolic challenges and clearance mechanisms orchestrated by host programmed cell death pathways (PCDs), including apoptosis, pyroptosis and necroptosis. Mounting evidence suggests that S. aureus deploys pathoadaptive mechanisms that modulate the expression of its virulence factors to prevent elimination through PCD pathways. In this review, we critically analyse the current literature on the interplay between S. aureus virulence factors with the key, intertwined nodes of PCD. We discuss how S. aureus adaptation to the human host plays an essential role in the evasion of PCD, and we consider future directions to study S. aureus-PCD interactions.Staphylococcus aureus is a major opportunistic human pathogen that is globally prevalent. Although S. aureus and humans may have co-evolved to the point of commensalism, the bacterium is equipped with virulence factors causing devastating infections. The adoption of an intracellular lifestyle by S. aureus is an important facet of its pathogenesis. Occupying a privileged intracellular compartment permits evasion from the bactericidal actions of host immunity and antibiotics. However, this localization exposes S. aureus to cell-intrinsic processes comprising autophagy, metabolic challenges and clearance mechanisms orchestrated by host programmed cell death pathways (PCDs), including apoptosis, pyroptosis and necroptosis. Mounting evidence suggests that S. aureus deploys pathoadaptive mechanisms that modulate the expression of its virulence factors to prevent elimination through PCD pathways. In this review, we critically analyse the current literature on the interplay between S. aureus virulence factors with the key, intertwined nodes of PCD. We discuss how S. aureus adaptation to the human host plays an essential role in the evasion of PCD, and we consider future directions to study S. aureus-PCD interactions.
Staphylococcus aureus is a major opportunistic human pathogen that is globally prevalent. Although S. aureus and humans may have co‐evolved to the point of commensalism, the bacterium is equipped with virulence factors causing devastating infections. The adoption of an intracellular lifestyle by S. aureus is an important facet of its pathogenesis. Occupying a privileged intracellular compartment permits evasion from the bactericidal actions of host immunity and antibiotics. However, this localization exposes S. aureus to cell‐intrinsic processes comprising autophagy, metabolic challenges and clearance mechanisms orchestrated by host programmed cell death pathways (PCDs), including apoptosis, pyroptosis and necroptosis. Mounting evidence suggests that S. aureus deploys pathoadaptive mechanisms that modulate the expression of its virulence factors to prevent elimination through PCD pathways. In this review, we critically analyse the current literature on the interplay between S. aureus virulence factors with the key, intertwined nodes of PCD. We discuss how S. aureus adaptation to the human host plays an essential role in the evasion of PCD, and we consider future directions to study S. aureus–PCD interactions.
Author Stinear, Timothy P.
Soe, Ye Mon
Hachani, Abderrahman
Bedoui, Sammy
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Issue 5
Keywords PCD
pyroptosis
autophagy
ferroptosis
intracellular pathogen
apoptosis
metabolism
programmed cell death
Staphylococcus aureus
necroptosis
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2013; 8
2012; 12
2019; 165
2018; 175
2018; 7
2018; 9
2018; 8
2007; 179
2018; 3
2012; 132
2009; 10
2019; 20
2013; 2013
2020; 297
2018; e4
2019; 21
2015; 83
2005; 73
2007; 9
2006; 440
2019; 29
2018; 32
2010; 5
2014; 12
2010; 7
2017; 205
2019; 7
2019; 9
2004; 303
2007; 282
2020; 41
2000; 68
2005; 115
2013; 342
2015; 526
2013; 340
2016; 18
2011; 3
2016; 17
2016; 16
2011; 6
2017; 135
2018; 20
2014; 159
2012; 31
2018; 24
2001; 155
2016; 4
2016; 6
2021; 59
2016; 7
2015; 61
2015; 112
2015; 197
2020; 28
2008; 45
2009; 183
2019; 216
2020; 22
2020; 21
2016; 213
2016; 29
2018; 11
2018; 10
2005; 18
2016; 26
2018; 16
2016; 8
2016; 24
2016; 23
2016; 22
2018; 362
2017; 6
2017; 7
2017; 8
2021; 20
2018; 360
2002; 51
2017; 43
2000; 8
1996; 183
2020; 59
2016; 73
2016; 70
2008; 3
2011; 17
2017; 199
2014; 210
2012; 205
2017; 114
2020; 6
2004; 75
2020; 5
2004; 72
2013; 15
2014; 209
2019; 61
2020; 53
2013; 13
2016; 113
2019; 116
2014; 58
2003; 5
2016; 84
2000; 165
2020; 0
2001; 13
2011; 29
2014; 6
2017; 129
2016; 88
2015; 13
2010; 78
2015; 1
2015; 15
2012; 80
2015; 17
2015; 6
2015; 18
1997; 65
2017; 25
2013; 45
2015; 11
2006; 4
2014; 192
2006; 2
2014; 111
2012; 148
2012; 149
2001; 69
2014; 82
2020; 108
2020; 109
2012; 92
2012; 90
2015; 28
2011; 108
2012; 3
2013; 39
2013; 32
2017; 13
1999; 274
2020; 117
2016; 535
2016
2017; 18
2020; 113
2009; 4
2008; 176
2009; 1
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Gaudet R. G. (e_1_2_9_53_1) 2016; 4
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Snippet Staphylococcus aureus is a major opportunistic human pathogen that is globally prevalent. Although S. aureus and humans may have co‐evolved to the point of...
Staphylococcus aureus is a major opportunistic human pathogen that is globally prevalent. Although S. aureus and humans may have co-evolved to the point of...
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SubjectTerms Antibiotics
Apoptosis
Autophagy
Cell death
Commensalism
ferroptosis
Intracellular
intracellular pathogen
Localization
metabolism
Necroptosis
Opportunist infection
Pathogenesis
PCD
Penicillin
Phagocytosis
programmed cell death
Pyroptosis
Staphylococcus aureus
Virulence
Virulence factors
Title Intracellular Staphylococcus aureus and host cell death pathways
URI https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fcmi.13317
https://www.ncbi.nlm.nih.gov/pubmed/33550697
https://www.proquest.com/docview/2511218138
https://www.proquest.com/docview/2487435286
Volume 23
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