Deneddylating enzyme SENP8 regulates neuronal development

• Published in: Journal of neurochemistry Vol. 165; no. 3; pp. 348 - 361
• Main Authors: Song, Jae‐man, Kang, Minji, Lee, Seungha, Kim, Jungho, Park, Sunha, Park, Da‐ha, Lee, Sanghyeon, Suh, Young Ho
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.05.2023
• Subjects: Actin; Animals; Axonogenesis; Clustering; Disks Large Homolog 4 Protein; Endopeptidases - metabolism; Enzymes; Glutamic acid receptors (metabotropic); Lysine; Maturation; metabotropic glutamate receptor 7; neurite outgrowth; Neurodevelopmental disorders; Neurogenesis; Neurons; Postsynaptic density; postsynaptic density protein 95; Proteins; Rats; Substrates; SUMO Peptidase Family Member, NEDD8 Specific; synapse maturation; Synapses - physiology; Synaptic clustering; Synaptogenesis; Therapeutic targets; Ubiquitination; Wnt protein; SUMO Peptidase Family Member, NEDD8 Specific; synapse maturation; neurite outgrowth; neurodevelopmental disorders; metabotropic glutamate receptor 7; postsynaptic density protein 95

Neddylation is a cellular process in which the neural precursor cell expressed, developmentally down‐regulated 8 (NEDD8) is conjugated to the lysine residue of target proteins via serial enzymatic cascades. Recently, it has been demonstrated that neddylation is required for synaptic clustering of me...