Whole‐exome sequencing suggests multiallelic inheritance for childhood‐onset Ménière's disease

• Published in: Annals of human genetics Vol. 83; no. 6; pp. 389 - 396
• Main Authors: Skarp, Sini, Kanervo, Laura, Kotimäki, Jouko, Sorri, Martti, Männikkö, Minna, Hietikko, Elina
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.11.2019
• Subjects: Cell death; Cell membranes; childhood onset; Children; Cytoskeleton; Etiology; exome sequencing; Genes; genetics; Inner ear; Meniere's disease; Ménière's disease; Vestibular system; exome sequencing; genetics; childhood onset; Ménière's disease

The genetic background of Ménière's disease (MD) was studied in one patient with childhood‐onset MD and his grandfather affected with middle age–onset MD. Whole‐exome sequencing was performed and the data were compared to 76 exomes from unrelated subjects without MD. Thirteen rare inner ear exp...