Activation of the Liver X Receptor Pathway Inhibits HBV Replication in Primary Human Hepatocytes

• Published in: Hepatology (Baltimore, Md.) Vol. 72; no. 6; pp. 1935 - 1948
• Main Authors: Zeng, Jing, Wu, Daitze, Hu, Hui, Young, John A.T., Yan, Zhipeng, Gao, Lu
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.12.2020
• Subjects: Agonists; Antigens, Viral - genetics; Antigens, Viral - isolation & purification; Antiviral activity; Antiviral Agents - pharmacology; Antiviral Agents - therapeutic use; Benzoates - pharmacology; Benzoates - therapeutic use; Benzylamines - pharmacology; Benzylamines - therapeutic use; Cell lines; Cells, Cultured; Cholesterol; Cholesterol 7-alpha-Hydroxylase - genetics; Cholesterol 7-alpha-Hydroxylase - metabolism; Chronic infection; Circular DNA; CYP7A1 gene; Deoxyribonucleic acid; DNA; DNA, Viral - isolation & purification; Drug Evaluation, Preclinical; Gene expression; Gene Knockdown Techniques; Hepatitis B; Hepatitis B - drug therapy; Hepatitis B - virology; Hepatitis B virus - drug effects; Hepatitis B virus - physiology; Hepatocytes; Hepatology; Heterocyclic Compounds, 4 or More Rings - pharmacology; Humans; Hydrocarbons, Fluorinated - pharmacology; Hydrocarbons, Fluorinated - therapeutic use; Hydroxylase; Indazoles - pharmacology; Indazoles - therapeutic use; Infections; Lipid metabolism; Liver - cytology; Liver - metabolism; Liver X receptors; Liver X Receptors - agonists; Liver X Receptors - antagonists & inhibitors; Liver X Receptors - metabolism; Metabolism; Nuclear receptors; Primary Cell Culture; Replication; RNA, Viral - isolation & purification; Signal Transduction - drug effects; siRNA; Sulfonamides - pharmacology; Sulfonamides - therapeutic use; Transcription; Virus Replication - drug effects

Background and Aims Hepatitis B virus (HBV) infection is ranked among the top health priorities worldwide. Accumulating evidence suggests that HBV infection and replication are closely associated with liver metabolism. The liver X receptors (LXRs), which belong to the superfamily of nuclear hormone...