Inhibition of PI3K/Akt/NF‐κB signaling with leonurine for ameliorating the progression of osteoarthritis: In vitro and in vivo studies - Hu, Zhi‐Chao; Gong, Lan‐Fang; Li, Xiao‐Bin; Fu, Xin; Xuan, Jiang‐Wei; Feng, Zhen‐Hua; Ni, Wen‐Fei (Journal of cellular physiology, 2019)
Keywords: 1-Phosphatidylinositol 3-kinase; AKT protein; Animals; Arthritis; Biocompatibility; Biomedical materials; Cartilage; Cartilage (articular); Cartilage diseases; Cascades; Cells, Cultured; Chemical compounds; Collagenase 3; Cyclooxygenase 2 - metabolism; Cytokines; Degeneration; Dinoprostone - metabolism; Down-Regulation - drug effects; Extracellular matrix; Extracellular Matrix - drug effects; Extracellular Matrix - metabolism; Gallic Acid - analogs & derivatives; Gallic Acid - pharmacology; Humans; In vivo methods and tests; Interleukin-1beta - metabolism; Interleukin-6 - metabolism; Interleukins; leonurine (LN); Male; Mice; Mice, Inbred C57BL; Molecular docking; Molecular Docking Simulation - methods; NF-kappa B - metabolism; Nitric oxide; Nitric Oxide - metabolism; Nitric Oxide Synthase Type II - metabolism; Nitric-oxide synthase; Osteoarthritis; osteoarthritis (OA); Osteoarthritis - drug therapy; Osteoarthritis - metabolism; Pharmacology; Phosphatidylinositol 3-Kinases - metabolism; PI3K/Akt/NF‐κB; Pretreatment; Prostaglandin E2; Prostaglandin endoperoxide synthase; Protective Agents - pharmacology; Proto-Oncogene Proteins c-akt - metabolism; Signal transduction; Signal Transduction - drug effects; Signaling; Thrombospondin; Tumor necrosis factor-α; leonurine (LN); osteoarthritis (OA); PI3K/Akt/NF-κB