Esophageal mucosal innervation in functional heartburn: Closer to healthy asymptomatic subjects than to non‐erosive reflux disease patients

• Published in: Neurogastroenterology and motility Vol. 31; no. 9; pp. e13667 - n/a
• Main Authors: Nikaki, Kornilia, Woodland, Philip, Lee, Chung, Ghisa, Matteo, Marinelli, Carla, Savarino, Edoardo, Sifrim, Daniel
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.09.2019
• Subjects: Barrett's esophagus; Calcitonin gene-related peptide; Esophagitis; Esophagus; Fibers; functional heartburn; Gastroesophageal reflux; Heart; Innervation; Mucosa; Nerves; non‐erosive gastroesophageal reflux disease; oesophageal mucosa innervation; Pain perception; Sensory neurons; non-erosive gastroesophageal reflux disease; oesophageal mucosa innervation; functional heartburn

Background Mucosal innervation in non‐erosive reflux disease (NERD; pathological esophageal acid exposure, normal macroscopic mucosa) is clearly distinct from that of healthy volunteers (HV) and from patients with esophagitis or Barrett's esophagus: The nerves in NERD are situated much closer t...