Preoperative prognostic nutritional index and systemic immune‐inflammation index predict survival outcomes in osteosarcoma: A comparison between young and elderly patients

• Published in: Journal of surgical oncology Vol. 125; no. 4; pp. 754 - 765
• Main Authors: Ma, Cong, Yu, Ronghui, Li, Junhong, Guo, Jingjing, Xu, Jianyun, Wang, Xiaoyan, Liu, Ping
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.03.2022
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Biomarkers; Biomarkers, Tumor - analysis; Blood Platelets - pathology; Bone cancer; Bone Neoplasms - drug therapy; Bone Neoplasms - immunology; Bone Neoplasms - mortality; Bone Neoplasms - pathology; Female; Follow-Up Studies; Humans; Inflammation; Inflammation - drug therapy; Inflammation - immunology; Inflammation - mortality; Inflammation - pathology; Lymphatic Metastasis; Lymphocytes - pathology; Male; Medical prognosis; Middle Aged; Neoadjuvant Therapy - mortality; Neoplasm Recurrence, Local - drug therapy; Neoplasm Recurrence, Local - immunology; Neoplasm Recurrence, Local - mortality; Neoplasm Recurrence, Local - pathology; Neutrophils - pathology; Nutrition Assessment; Nutritional status; osteosarcoma; Osteosarcoma - drug therapy; Osteosarcoma - immunology; Osteosarcoma - mortality; Osteosarcoma - secondary; Preoperative Care; Prognosis; prognostic nutritional index; Retrospective Studies; ROC Curve; Sarcoma; Survival Rate; systemic immune‐inflammation index; Young Adult; young and elderly; systemic immune-inflammation index; prognostic nutritional index; young and elderly; prognosis; osteosarcoma

Objective This retrospective study of patients with osteosarcoma investigated the following biomarkers of inflammation and nutritional status: neutrophil‐to‐lymphocyte ratio, platelet‐to‐lymphocyte ratio, prognostic nutritional index (PNI), and systemic immune‐inflammation index (SII). The efficacie...