Interleukin-8 is a chemo-attractant for eosinophils purified from subjects with a blood eosinophilia but not from normal healthy subjects

• Published in: Clinical and experimental allergy Vol. 23; no. 12; pp. 1027 - 1036
• Main Authors: SEHMI, R., CROMWELL, O., WARDLAW, A. J., MOQBEL, R., KAY, A. B.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.12.1993; Blackwell
• Subjects: Biological and medical sciences; Cells, Cultured; Chemotactic Factors - pharmacology; Chemotaxis, Leukocyte - drug effects; Dose-Response Relationship, Drug; Eosinophilia - blood; Eosinophilia - pathology; Eosinophils - drug effects; Eosinophils - physiology; Fetal Blood - cytology; Hematologic and hematopoietic diseases; Humans; Interleukin-3 - pharmacology; Interleukin-5 - pharmacology; Interleukin-8 - pharmacology; Medical sciences; N-Formylmethionine Leucyl-Phenylalanine - pharmacology; Other diseases. Hematologic involvement in other diseases; Platelet Activating Factor - pharmacology; Human; Interleukin 6; Cytokine; Granulocyte; Hemopathy; Chemotaxis; Eosinophilia; Eosinophil

Summary Interleukin‐8 (IL‐8), a pro‐inflammatory cytokine with potent neutrophil chemotactic activity, was studied for its effect on eosinophil migration responses, in vitro. Normal density eosinophils were isolated from healthy, non‐atopic subjects <0.35 × 109 eosinophils/1) and individuals with...