Risk of Venous Thromboembolism With Tofacitinib Versus Tumor Necrosis Factor Inhibitors in Cardiovascular Risk‐Enriched Rheumatoid Arthritis Patients

• Published in: Arthritis & rheumatology (Hoboken, N.J.) Vol. 76; no. 8; pp. 1218 - 1229
• Main Authors: Charles‐Schoeman, Christina, Fleischmann, Roy, Mysler, Eduardo, Greenwald, Maria, Ytterberg, Steven R., Koch, Gary G., Bhatt, Deepak L., Wang, Cunshan, Mikuls, Ted R., Chen, All‐shine, Connell, Carol A., Woolcott, John C., Menon, Sujatha, Chen, Yan, Lee, Kristen, Szekanecz, Zoltán
• Format: Journal Article
• Language: English
• Published: Boston, USA Wiley Periodicals, Inc 01.08.2024; Wiley Subscription Services, Inc
• Subjects: Aged; Antirheumatic Agents - adverse effects; Antirheumatic Agents - therapeutic use; Arthritis; Arthritis, Rheumatoid - complications; Arthritis, Rheumatoid - drug therapy; Autoimmune diseases; Body mass index; Body size; Cardiovascular diseases; Embolism; Female; Health risks; Humans; Incidence; Inhibitors; Intervals; Lung diseases; Male; Middle Aged; Piperidines - adverse effects; Piperidines - therapeutic use; Population studies; Proportional Hazards Models; Protein Kinase Inhibitors - adverse effects; Protein Kinase Inhibitors - therapeutic use; Pulmonary Embolism - epidemiology; Pyrimidines - adverse effects; Pyrimidines - therapeutic use; Pyrroles - adverse effects; Pyrroles - therapeutic use; Regression analysis; Regression models; Rheumatoid arthritis; Risk assessment; Risk Factors; Surveillance; Thromboembolism; Thrombosis; Tumor necrosis factor; Tumor Necrosis Factor Inhibitors - adverse effects; Tumor Necrosis Factor Inhibitors - therapeutic use; Tumor necrosis factor-TNF; Venous Thromboembolism - epidemiology; Venous Thrombosis - chemically induced; Venous Thrombosis - epidemiology

Objective The ORAL Surveillance trial found a dose‐dependent increase in venous thromboembolism (VTE) and pulmonary embolism (PE) events with tofacitinib versus tumor necrosis factor inhibitors (TNFi). We aimed to assess VTE incidence over time and explore risk factors of VTE, including disease acti...