Cell type- and stage-specific expression of the CD20/B1 antigen correlates with the activity of a diverged octamer DNA motif present in its promoter

• Published in: The Journal of biological chemistry Vol. 268; no. 8; pp. 5949 - 5956
• Main Authors: THEVENIN, C, LUCAS, B. P, KOZLOW, E. J, KEHRL, J. H
• Format: Journal Article
• Language: English
• Published: Bethesda, MD American Society for Biochemistry and Molecular Biology 15.03.1993
• Subjects: Antigens, CD - genetics; Antigens, CD - metabolism; Antigens, CD20; Antigens, Differentiation, B-Lymphocyte - genetics; Antigens, Differentiation, B-Lymphocyte - metabolism; B-Lymphocytes - drug effects; B-Lymphocytes - immunology; B-Lymphocytes - metabolism; Base Sequence; Binding Sites; Biological and medical sciences; Cell Line; DNA - metabolism; DNA Mutational Analysis; DNA-Binding Proteins - genetics; DNA-Binding Proteins - metabolism; Fundamental and applied biological sciences. Psychology; HeLa Cells; Host Cell Factor C1; Humans; Molecular and cellular biology; Molecular genetics; Molecular Sequence Data; Mutation; Octamer Transcription Factor-1; Octamer Transcription Factor-2; Promoter Regions, Genetic; Receptors, Complement 3d - genetics; Sequence Deletion; Tetradecanoylphorbol Acetate - pharmacology; Transcription Factors - metabolism; Transcription. Transcription factor. Splicing. Rna processing; Transcriptional Activation; Tumor Cells, Cultured; Human; Transcription; Transcription promoter; Cell cycle; Regulatory sequence; B-Lymphocyte; Gel retardation technique

The CD20(B1) gene encodes a B cell-specific protein involved in the regulation of human B cell proliferation and differentiation. Studies with 5' deletion CD20 promoter-CAT constructs have previously revealed two regions of the promoter between bases -186 and -280 and between bases -280 and -45...