Transient elastography is useful in diagnosing biliary atresia and predicting prognosis after hepatoportoenterostomy
We investigated the utility of transient elastography (TE) for diagnosing biliary atresia (BA) in cholestatic infants and predicting the outcome of BA. Forty‐eight cholestatic infants (9‐87 days of age) with direct bilirubin level >1 mg/dL were enrolled. Liver stiffness measurement (LSM) by TE wa...
Saved in:
| Published in | Hepatology (Baltimore, Md.) Vol. 68; no. 2; pp. 616 - 624 |
|---|---|
| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Wolters Kluwer Health, Inc
01.08.2018
|
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | We investigated the utility of transient elastography (TE) for diagnosing biliary atresia (BA) in cholestatic infants and predicting the outcome of BA. Forty‐eight cholestatic infants (9‐87 days of age) with direct bilirubin level >1 mg/dL were enrolled. Liver stiffness measurement (LSM) by TE was performed during the cholestasis workup, and 15 subjects were diagnosed as BA. We assessed liver histology using liver biopsies from 36 subjects and graded fibrosis status using the METAVIR score. BA infants had significantly higher LSM values and METAVIR scores than non‐BA cholestatic infants. A receiver operating characteristic (ROC) curve analysis showed that an LSM >7.7 kPa was predictive of BA among cholestatic infants (sensitivity = 80%; specificity = 97%; area under the curve [AUC] = 85.3%; P = 0.0001). Cholestatic infants with an LSM >7.7 kPa were more likely to be diagnosed with BA (odds ratio [OR] = 128; P < 0.001). Very early measurement of LSM after hepatoportoenterostomy (HPE) is associated with occurrence of thrombocytopenia, splenomegaly, and esophageal varices 6 months post‐HPE. Five of the BA subjects were awaiting or had received liver transplantation (LT), and they had a significantly higher LSM measured 1 week post‐HPE than that in the other BA subjects (26.0 vs. 10.8 kPa; P = 0.006). A Cox proportional analysis demonstrated that the need for LT was significantly higher in BA subjects with LSM >16 kPa measured 1 week post‐HPE than other BA subjects (hazard ratio [HR] = 10.16; P = 0.04). Conclusion: LSM assessment during the workup of cholestatic infants may facilitate the diagnosis of BA. LSM post‐HPE may predict complications and the need for early LT in infants with BA. (Hepatology 2018). |
|---|---|
| AbstractList | We investigated the utility of transient elastography (TE) for diagnosing biliary atresia (BA) in cholestatic infants and predicting the outcome of BA. Forty-eight cholestatic infants (9-87 days of age) with direct bilirubin level >1 mg/dL were enrolled. Liver stiffness measurement (LSM) by TE was performed during the cholestasis workup, and 15 subjects were diagnosed as BA. We assessed liver histology using liver biopsies from 36 subjects and graded fibrosis status using the METAVIR score. BA infants had significantly higher LSM values and METAVIR scores than non-BA cholestatic infants. A receiver operating characteristic (ROC) curve analysis showed that an LSM >7.7 kPa was predictive of BA among cholestatic infants (sensitivity = 80%; specificity = 97%; area under the curve [AUC] = 85.3%; P = 0.0001). Cholestatic infants with an LSM >7.7 kPa were more likely to be diagnosed with BA (odds ratio [OR] = 128; P < 0.001). Very early measurement of LSM after hepatoportoenterostomy (HPE) is associated with occurrence of thrombocytopenia, splenomegaly, and esophageal varices 6 months post-HPE. Five of the BA subjects were awaiting or had received liver transplantation (LT), and they had a significantly higher LSM measured 1 week post-HPE than that in the other BA subjects (26.0 vs. 10.8 kPa; P = 0.006). A Cox proportional analysis demonstrated that the need for LT was significantly higher in BA subjects with LSM >16 kPa measured 1 week post-HPE than other BA subjects (hazard ratio [HR] = 10.16; P = 0.04).
LSM assessment during the workup of cholestatic infants may facilitate the diagnosis of BA. LSM post-HPE may predict complications and the need for early LT in infants with BA. (Hepatology 2018). We investigated the utility of transient elastography (TE) for diagnosing biliary atresia (BA) in cholestatic infants and predicting the outcome of BA. Forty-eight cholestatic infants (9-87 days of age) with direct bilirubin level >1 mg/dL were enrolled. Liver stiffness measurement (LSM) by TE was performed during the cholestasis workup, and 15 subjects were diagnosed as BA. We assessed liver histology using liver biopsies from 36 subjects and graded fibrosis status using the METAVIR score. BA infants had significantly higher LSM values and METAVIR scores than non-BA cholestatic infants. A receiver operating characteristic (ROC) curve analysis showed that an LSM >7.7 kPa was predictive of BA among cholestatic infants (sensitivity = 80%; specificity = 97%; area under the curve [AUC] = 85.3%; P = 0.0001). Cholestatic infants with an LSM >7.7 kPa were more likely to be diagnosed with BA (odds ratio [OR] = 128; P < 0.001). Very early measurement of LSM after hepatoportoenterostomy (HPE) is associated with occurrence of thrombocytopenia, splenomegaly, and esophageal varices 6 months post-HPE. Five of the BA subjects were awaiting or had received liver transplantation (LT), and they had a significantly higher LSM measured 1 week post-HPE than that in the other BA subjects (26.0 vs. 10.8 kPa; P = 0.006). A Cox proportional analysis demonstrated that the need for LT was significantly higher in BA subjects with LSM >16 kPa measured 1 week post-HPE than other BA subjects (hazard ratio [HR] = 10.16; P = 0.04).We investigated the utility of transient elastography (TE) for diagnosing biliary atresia (BA) in cholestatic infants and predicting the outcome of BA. Forty-eight cholestatic infants (9-87 days of age) with direct bilirubin level >1 mg/dL were enrolled. Liver stiffness measurement (LSM) by TE was performed during the cholestasis workup, and 15 subjects were diagnosed as BA. We assessed liver histology using liver biopsies from 36 subjects and graded fibrosis status using the METAVIR score. BA infants had significantly higher LSM values and METAVIR scores than non-BA cholestatic infants. A receiver operating characteristic (ROC) curve analysis showed that an LSM >7.7 kPa was predictive of BA among cholestatic infants (sensitivity = 80%; specificity = 97%; area under the curve [AUC] = 85.3%; P = 0.0001). Cholestatic infants with an LSM >7.7 kPa were more likely to be diagnosed with BA (odds ratio [OR] = 128; P < 0.001). Very early measurement of LSM after hepatoportoenterostomy (HPE) is associated with occurrence of thrombocytopenia, splenomegaly, and esophageal varices 6 months post-HPE. Five of the BA subjects were awaiting or had received liver transplantation (LT), and they had a significantly higher LSM measured 1 week post-HPE than that in the other BA subjects (26.0 vs. 10.8 kPa; P = 0.006). A Cox proportional analysis demonstrated that the need for LT was significantly higher in BA subjects with LSM >16 kPa measured 1 week post-HPE than other BA subjects (hazard ratio [HR] = 10.16; P = 0.04).LSM assessment during the workup of cholestatic infants may facilitate the diagnosis of BA. LSM post-HPE may predict complications and the need for early LT in infants with BA. (Hepatology 2018).CONCLUSIONLSM assessment during the workup of cholestatic infants may facilitate the diagnosis of BA. LSM post-HPE may predict complications and the need for early LT in infants with BA. (Hepatology 2018). We investigated the utility of transient elastography (TE) for diagnosing biliary atresia (BA) in cholestatic infants and predicting the outcome of BA. Forty‐eight cholestatic infants (9‐87 days of age) with direct bilirubin level >1 mg/dL were enrolled. Liver stiffness measurement (LSM) by TE was performed during the cholestasis workup, and 15 subjects were diagnosed as BA. We assessed liver histology using liver biopsies from 36 subjects and graded fibrosis status using the METAVIR score. BA infants had significantly higher LSM values and METAVIR scores than non‐BA cholestatic infants. A receiver operating characteristic (ROC) curve analysis showed that an LSM >7.7 kPa was predictive of BA among cholestatic infants (sensitivity = 80%; specificity = 97%; area under the curve [AUC] = 85.3%; P = 0.0001). Cholestatic infants with an LSM >7.7 kPa were more likely to be diagnosed with BA (odds ratio [OR] = 128; P < 0.001). Very early measurement of LSM after hepatoportoenterostomy (HPE) is associated with occurrence of thrombocytopenia, splenomegaly, and esophageal varices 6 months post‐HPE. Five of the BA subjects were awaiting or had received liver transplantation (LT), and they had a significantly higher LSM measured 1 week post‐HPE than that in the other BA subjects (26.0 vs. 10.8 kPa; P = 0.006). A Cox proportional analysis demonstrated that the need for LT was significantly higher in BA subjects with LSM >16 kPa measured 1 week post‐HPE than other BA subjects (hazard ratio [HR] = 10.16; P = 0.04). Conclusion: LSM assessment during the workup of cholestatic infants may facilitate the diagnosis of BA. LSM post‐HPE may predict complications and the need for early LT in infants with BA. (H epatology 2018). We investigated the utility of transient elastography (TE) for diagnosing biliary atresia (BA) in cholestatic infants and predicting the outcome of BA. Forty‐eight cholestatic infants (9‐87 days of age) with direct bilirubin level >1 mg/dL were enrolled. Liver stiffness measurement (LSM) by TE was performed during the cholestasis workup, and 15 subjects were diagnosed as BA. We assessed liver histology using liver biopsies from 36 subjects and graded fibrosis status using the METAVIR score. BA infants had significantly higher LSM values and METAVIR scores than non‐BA cholestatic infants. A receiver operating characteristic (ROC) curve analysis showed that an LSM >7.7 kPa was predictive of BA among cholestatic infants (sensitivity = 80%; specificity = 97%; area under the curve [AUC] = 85.3%; P = 0.0001). Cholestatic infants with an LSM >7.7 kPa were more likely to be diagnosed with BA (odds ratio [OR] = 128; P < 0.001). Very early measurement of LSM after hepatoportoenterostomy (HPE) is associated with occurrence of thrombocytopenia, splenomegaly, and esophageal varices 6 months post‐HPE. Five of the BA subjects were awaiting or had received liver transplantation (LT), and they had a significantly higher LSM measured 1 week post‐HPE than that in the other BA subjects (26.0 vs. 10.8 kPa; P = 0.006). A Cox proportional analysis demonstrated that the need for LT was significantly higher in BA subjects with LSM >16 kPa measured 1 week post‐HPE than other BA subjects (hazard ratio [HR] = 10.16; P = 0.04). Conclusion: LSM assessment during the workup of cholestatic infants may facilitate the diagnosis of BA. LSM post‐HPE may predict complications and the need for early LT in infants with BA. (Hepatology 2018). |
| Author | Lee, Chee‐Seng Lin, Wen‐Hsi Jeng, Yung‐Ming Hsu, Hong‐Yuan Wu, Jia‐Feng Ni, Yen‐Hsuan Chang, Mei‐Hwei Chen, Huey‐Ling |
| Author_xml | – sequence: 1 givenname: Jia‐Feng surname: Wu fullname: Wu, Jia‐Feng organization: National Taiwan University Hospital – sequence: 2 givenname: Chee‐Seng surname: Lee fullname: Lee, Chee‐Seng organization: National Taiwan University Hospital – sequence: 3 givenname: Wen‐Hsi surname: Lin fullname: Lin, Wen‐Hsi organization: National Taiwan University Hospital – sequence: 4 givenname: Yung‐Ming surname: Jeng fullname: Jeng, Yung‐Ming organization: National Taiwan University Hospital – sequence: 5 givenname: Huey‐Ling surname: Chen fullname: Chen, Huey‐Ling organization: Taipei Tzu Chi Hospital – sequence: 6 givenname: Yen‐Hsuan surname: Ni fullname: Ni, Yen‐Hsuan organization: Taipei Tzu Chi Hospital – sequence: 7 givenname: Hong‐Yuan surname: Hsu fullname: Hsu, Hong‐Yuan organization: National Taiwan University Hospital – sequence: 8 givenname: Mei‐Hwei surname: Chang fullname: Chang, Mei‐Hwei email: changmh@ntu.edu.tw organization: Taipei Tzu Chi Hospital |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/29486516$$D View this record in MEDLINE/PubMed |
| BookMark | eNp90cFu1DAQBmALFdFt4cALIEtc6CHt2Ikd54iq0iJVgkM5R5NkvHWVtYPtCO3b43YLh0pw8sHfjMf_nLAjHzwx9l7AuQCQF_e0nMvOKP2KbYSSbVXXCo7YBmQLVSfq7pidpPQAAF0jzRt2LLvGaCX0huW7iD458pnTjCmHbcTlfs9d4msiu87ceT453PqQnN_ywc0O455jjpQccvQTXyJNbsyP10sMTzJxtJkiL5NhDkuIOZQnKIbywm7_lr22OCd693yesh9fru4ub6rbb9dfLz_fVmOtal0NChutNYlOK1CTglbKUVirJ4uqkQStpoasEQOg0WAJtWkAUdtB15Md61P26dC3jPVzpZT7nUsjzTN6CmvqZQlEisYYKPTjC_oQ1ujLdEUZXTfCdG1RH57VOuxo6pfodiWN_k-eBZwdwFi-miLZv0RA_7irviTSP-2q2IsXdnQZsws-R3Tz_yp-uZn2_27d31x9P1T8Btpfp4U |
| CitedBy_id | crossref_primary_10_1016_j_sempedsurg_2020_150943 crossref_primary_10_1186_s12887_020_02172_z crossref_primary_10_1007_s12519_018_0197_8 crossref_primary_10_1016_j_sempedsurg_2020_150945 crossref_primary_10_1016_j_acra_2020_08_035 crossref_primary_10_1016_j_transproceed_2024_01_005 crossref_primary_10_1038_s41467_021_21466_z crossref_primary_10_1007_s00247_022_05480_x crossref_primary_10_3390_diagnostics12051092 crossref_primary_10_1002_jum_15482 crossref_primary_10_1016_j_dld_2021_09_011 crossref_primary_10_1007_s00535_023_02051_1 crossref_primary_10_1186_s12887_019_1487_6 crossref_primary_10_1007_s00383_022_05240_w crossref_primary_10_1097_MPG_0000000000002450 crossref_primary_10_1007_s12098_020_03561_z crossref_primary_10_3389_fped_2020_607506 crossref_primary_10_5223_pghn_2022_25_5_353 crossref_primary_10_1016_j_jpeds_2018_12_006 crossref_primary_10_1038_s41390_019_0610_6 crossref_primary_10_1016_j_pedneo_2018_05_002 crossref_primary_10_1007_s00383_018_4317_2 crossref_primary_10_1111_liv_14598 crossref_primary_10_3390_children9111676 crossref_primary_10_3390_diagnostics12010051 crossref_primary_10_1111_petr_13815 crossref_primary_10_3389_fped_2019_00279 crossref_primary_10_1038_s41390_024_03772_6 crossref_primary_10_1001_jama_2020_0837 crossref_primary_10_3389_fped_2022_972855 crossref_primary_10_1136_bmjopen_2020_042129 crossref_primary_10_3389_fped_2021_641318 crossref_primary_10_1016_j_pedneo_2021_04_005 crossref_primary_10_3748_wjg_v28_i32_4726 crossref_primary_10_3748_wjg_v30_i9_1043 crossref_primary_10_1007_s00431_021_04098_9 crossref_primary_10_1002_jum_16075 crossref_primary_10_1177_02841851211055820 crossref_primary_10_1186_s12887_022_03831_z crossref_primary_10_1007_s00383_024_05740_x crossref_primary_10_1016_j_jpeds_2019_01_026 crossref_primary_10_1097_MOP_0000000000001048 crossref_primary_10_1111_joim_13097 crossref_primary_10_1002_aid2_13194 crossref_primary_10_1016_j_jfma_2018_12_018 crossref_primary_10_1542_neo_22_12_e819 crossref_primary_10_3389_fpubh_2022_973125 crossref_primary_10_1002_jhbp_628 crossref_primary_10_1111_hepr_13948 crossref_primary_10_3348_kjr_2020_0885 crossref_primary_10_1038_s41598_022_11140_9 crossref_primary_10_1002_hep_32777 crossref_primary_10_1016_j_jceh_2025_102543 crossref_primary_10_3348_kjr_2022_0586 crossref_primary_10_1097_HEP_0000000000000048 crossref_primary_10_3389_fped_2022_837247 crossref_primary_10_1002_cld_843 crossref_primary_10_1186_s12916_024_03247_9 crossref_primary_10_12688_f1000research_16732_1 crossref_primary_10_1007_s00247_023_05796_2 crossref_primary_10_1007_s00261_021_02958_4 crossref_primary_10_1038_s41390_023_02818_5 crossref_primary_10_1002_jpn3_12278 crossref_primary_10_1007_s00431_021_04176_y |
| Cites_doi | 10.1016/j.jpedsurg.2007.08.032 10.1016/j.dld.2011.04.006 10.1002/hep.24023 10.1007/s13312-015-0735-6 10.1203/PDR.0b013e3181d22a73 10.1007/BF02469507 10.1007/s002470050017 10.1371/journal.pone.0158132 10.1002/hep.20185 10.1186/1471-230X-11-41 10.7863/ultra.15.08031 10.4254/wjh.v8.i33.1471 10.1016/j.jpeds.2015.11.058 10.1002/hep.510240201 10.1111/liv.12001 10.1016/S0140-6736(09)60946-6 10.1016/S1089-3261(05)70141-0 10.4238/2015.April.22.15 10.1172/JCI57728 10.1172/JCI38879 10.2214/AJR.15.15336 10.1371/journal.pone.0182089 10.1371/journal.pone.0088268 10.3748/wjg.v21.i22.6931 10.1002/hep.21790 10.1371/journal.pone.0176275 10.1002/hep.27045 10.1053/j.gastro.2007.04.031 |
| ContentType | Journal Article |
| Copyright | 2018 by the American Association for the Study of Liver Diseases. Copyright © 2018 by the American Association for the Study of Liver Diseases. |
| Copyright_xml | – notice: 2018 by the American Association for the Study of Liver Diseases. – notice: Copyright © 2018 by the American Association for the Study of Liver Diseases. |
| DBID | AAYXX CITATION NPM 7T5 7TM 7TO 7U9 H94 K9. 7X8 |
| DOI | 10.1002/hep.29856 |
| DatabaseName | CrossRef PubMed Immunology Abstracts Nucleic Acids Abstracts Oncogenes and Growth Factors Abstracts Virology and AIDS Abstracts AIDS and Cancer Research Abstracts ProQuest Health & Medical Complete (Alumni) MEDLINE - Academic |
| DatabaseTitle | CrossRef PubMed AIDS and Cancer Research Abstracts ProQuest Health & Medical Complete (Alumni) Immunology Abstracts Virology and AIDS Abstracts Oncogenes and Growth Factors Abstracts Nucleic Acids Abstracts MEDLINE - Academic |
| DatabaseTitleList | PubMed MEDLINE - Academic CrossRef AIDS and Cancer Research Abstracts |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1527-3350 |
| EndPage | 624 |
| ExternalDocumentID | 29486516 10_1002_hep_29856 HEP29856 |
| Genre | article Research Support, Non-U.S. Gov't Journal Article |
| GrantInformation_xml | – fundername: Taiwan Children Liver Foundation – fundername: Paujar Charity Foundation |
| GroupedDBID | --- --K .3N .55 .GA .GJ .Y3 05W 0R~ 10A 186 1B1 1CY 1L6 1OB 1OC 1ZS 1~5 24P 31~ 33P 3O- 3SF 3WU 4.4 4G. 4ZD 50Y 50Z 51W 51X 52M 52N 52O 52P 52R 52S 52T 52U 52V 52W 52X 53G 5GY 5RE 5VS 7-5 702 7PT 8-0 8-1 8-3 8-4 8-5 8UM 930 A01 A03 AAEDT AAESR AAEVG AAHHS AALRI AANHP AAONW AAQFI AAQQT AAQXK AASGY AAXRX AAXUO AAZKR ABCQN ABCUV ABEML ABIJN ABLJU ABMAC ABOCM ABPVW ABWVN ABXGK ACAHQ ACBWZ ACCFJ ACCZN ACGFS ACLDA ACMXC ACPOU ACPRK ACRPL ACSCC ACXBN ACXQS ACYXJ ADBBV ADEOM ADIZJ ADKYN ADMGS ADMUD ADNMO ADOZA ADXAS ADZMN ADZOD AECAP AEEZP AEIMD AENEX AEQDE AEUQT AFBPY AFFNX AFGKR AFPWT AFUWQ AFZJQ AHMBA AIACR AIURR AIWBW AJAOE AJBDE ALAGY ALMA_UNASSIGNED_HOLDINGS ALUQN AMBMR AMYDB ASPBG ATUGU AVWKF AZBYB AZFZN AZVAB BAFTC BAWUL BDRZF BHBCM BMXJE BROTX BRXPI BY8 C45 CAG COF CS3 D-6 D-7 D-E D-F DCZOG DIK DPXWK DR2 DRFUL DRMAN DRSTM DU5 E3Z EBS EJD F00 F01 F04 F5P FD8 FDB FEDTE FGOYB FUBAC G-S G.N GNP GODZA H.X HBH HF~ HHY HHZ HVGLF HZ~ IHE IX1 J0M J5H JPC KBYEO KQQ LATKE LC2 LC3 LEEKS LH4 LITHE LOXES LP6 LP7 LUTES LW6 LYRES M41 M65 MJL MK4 MRFUL MRMAN MRSTM MSFUL MSMAN MSSTM MXFUL MXMAN MXSTM N04 N05 N4W N9A NF~ NNB NQ- O66 O9- OIG OK1 OVD P2P P2W P2X P2Z P4B P4D PALCI PQQKQ Q.N Q11 QB0 QRW R.K R2- RGB RIG RIWAO RJQFR ROL RPZ RWI RX1 RYL SEW SSZ SUPJJ TEORI UB1 V2E V9Y W2D W8V W99 WBKPD WH7 WHWMO WIB WIH WIJ WIK WIN WJL WOHZO WQJ WRC WUP WVDHM WXI X7M XG1 XV2 ZGI ZXP ZZTAW ~IA ~WT AAYXX ABJNI ACZKN AFNMH AGQPQ AHQVU CITATION MEWTI WXSBR AAMMB AEFGJ AGXDD AIDQK AIDYY NPM 7T5 7TM 7TO 7U9 ADSXY H94 K9. 7X8 |
| ID | FETCH-LOGICAL-c3536-b5a4666e196505d50722c1ff6dfa542e076e4ef81b0a860fea6840aa6fb63dfc3 |
| IEDL.DBID | DR2 |
| ISSN | 0270-9139 1527-3350 |
| IngestDate | Thu Jul 10 21:20:30 EDT 2025 Wed Aug 13 03:55:42 EDT 2025 Mon Jul 21 05:58:41 EDT 2025 Thu Apr 24 23:08:55 EDT 2025 Tue Jul 01 03:33:52 EDT 2025 Wed Jan 22 16:51:28 EST 2025 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 2 |
| Language | English |
| License | 2018 by the American Association for the Study of Liver Diseases. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c3536-b5a4666e196505d50722c1ff6dfa542e076e4ef81b0a860fea6840aa6fb63dfc3 |
| Notes | Potential conflict of interest: Nothing to report. Supported by Paujar Charity Foundation and Taiwan Children Liver Foundation. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 |
| PMID | 29486516 |
| PQID | 2086341897 |
| PQPubID | 996352 |
| PageCount | 9 |
| ParticipantIDs | proquest_miscellaneous_2009214880 proquest_journals_2086341897 pubmed_primary_29486516 crossref_primary_10_1002_hep_29856 crossref_citationtrail_10_1002_hep_29856 wiley_primary_10_1002_hep_29856_HEP29856 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | August 2018 2018-08-00 20180801 |
| PublicationDateYYYYMMDD | 2018-08-01 |
| PublicationDate_xml | – month: 08 year: 2018 text: August 2018 |
| PublicationDecade | 2010 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States – name: Hoboken |
| PublicationTitle | Hepatology (Baltimore, Md.) |
| PublicationTitleAlternate | Hepatology |
| PublicationYear | 2018 |
| Publisher | Wolters Kluwer Health, Inc |
| Publisher_xml | – name: Wolters Kluwer Health, Inc |
| References | 2015; 14 2000; 4 2016; 206 2015; 52 2009; 374 2011; 53 2003; 37 2011; 11 2009; 119 2014; 60 1983; 13 2012; 32 2016; 35 2016; 11 2010; 67 2004; 39 2007; 133 2000; 30 2017; 12 2015; 21 2011; 43 2007; 42 2014; 9 1996; 24 2016; 170 2007; 46 2016; 8 2011; 121 (hep29856-bib-0008-20241017) 2017; 12 (hep29856-bib-0013-20241017) 2016; 11 (hep29856-bib-0002-20241017) 2007; 46 (hep29856-bib-0005-20241017) 2000; 4 (hep29856-bib-0019-20241017) 2016; 35 (hep29856-bib-0021-20241017) 2016; 170 (hep29856-bib-0028-20241017) 2017; 12 (hep29856-bib-0006-20241017) 2003; 37 (hep29856-bib-0003-20241017) 2009; 374 (hep29856-bib-0020-20241017) 1996; 24 (hep29856-bib-0001-20241017) 2004; 39 (hep29856-bib-0018-20241017) 2011; 11 (hep29856-bib-0029-20241017) 2011; 43 (hep29856-bib-0015-20241017) 2015; 14 (hep29856-bib-0027-20241017) 2007; 133 (hep29856-bib-0025-20241017) 2009; 119 (hep29856-bib-0024-20241017) 2012; 32 (hep29856-bib-0004-20241017) 1983; 13 (hep29856-bib-0026-20241017) 2010; 67 (hep29856-bib-0007-20241017) 2011; 53 (hep29856-bib-0011-20241017) 2007; 42 (hep29856-bib-0014-20241017) 2014; 9 (hep29856-bib-0017-20241017) 2016; 8 (hep29856-bib-0009-20241017) 2015; 52 (hep29856-bib-0012-20241017) 2016; 206 (hep29856-bib-0023-20241017) 2011; 121 (hep29856-bib-0010-20241017) 2000; 30 (hep29856-bib-0016-20241017) 2015; 21 (hep29856-bib-0022-20241017) 2014; 60 |
| References_xml | – volume: 13 start-page: 265 year: 1983 end-page: 276 article-title: Advances in treatment of biliary atresia publication-title: Jpn J Surg – volume: 43 start-page: 659 year: 2011 end-page: 663 article-title: Non‐invasive methods can predict oesophageal varices in patients with biliary atresia after a Kasai procedure publication-title: Dig Liver Dis – volume: 11 start-page: 41 year: 2011 article-title: Transient elastography for predicting esophageal/gastric varices in children with biliary atresia publication-title: BMC Gastroenterol – volume: 46 start-page: 566 year: 2007 end-page: 581 article-title: Screening and outcomes in biliary atresia: summary of a National Institutes of Health workshop publication-title: Hepatology – volume: 52 start-page: 871 year: 2015 end-page: 879 article-title: Recent trends in the diagnosis and management of biliary atresia in developing countries publication-title: Indian Pediatr – volume: 37 start-page: 4 year: 2003 end-page: 21 article-title: Pathogenesis and outcome of biliary atresia: current concepts publication-title: J Pediatr Gastroenterol Nutr – volume: 119 start-page: 2281 year: 2009 end-page: 2290 article-title: Neonatal NK cells target the mouse duct epithelium via Nkg2d and drive tissue‐specific injury in experimental biliary atresia publication-title: J Clin Invest – volume: 30 start-page: 69 year: 2000 end-page: 73 article-title: Making the diagnosis of biliary atresia using the triangular cord sign and gallbladder length publication-title: Pediatr Radiol – volume: 39 start-page: 891 year: 2004 article-title: Biliary Atresia Research Consortium (BARC) publication-title: Hepatology – volume: 11 start-page: e0158132 year: 2016 article-title: Incremental value of MR cholangiopancreatography in diagnosis of biliary atresia publication-title: PLoS One – volume: 21 start-page: 6931 year: 2015 end-page: 6936 article-title: Assessment of liver fibrosis by Fibroscan as compared to liver biopsy in biliary atresia publication-title: World J Gastroenterol – volume: 133 start-page: 268 year: 2007 end-page: 277 article-title: Effector role of neonatal hepatic CD8 lymphocytes in epithelial injury and autoimmunity in experimental biliary atresia publication-title: Gastroenterology – volume: 24 start-page: 289 year: 1996 end-page: 293 article-title: An algorithm for the grading of activity in chronic hepatitis C. The METAVIR Cooperative Study Group publication-title: Hepatology – volume: 12 start-page: e0182089 year: 2017 article-title: Cxcr2 signaling and the microbiome suppress inflammation, bile duct injury, and the phenotype of experimental biliary atresia publication-title: PLoS One – volume: 4 start-page: 779 year: 2000 end-page: 804 article-title: Biliary atresia. A surgical perspective publication-title: Clin Liver Dis – volume: 206 start-page: W73 year: 2016 end-page: W82 article-title: Ultrasound for the diagnosis of biliary atresia: a meta‐analysis publication-title: AJR Am J Roentgenol – volume: 12 start-page: e0176275 year: 2017 article-title: Initial assessment of the infant with neonatal cholestasis—is this biliary atresia? publication-title: PLoS One – volume: 9 start-page: e88268 year: 2014 article-title: Three‐dimensional magnetic resonance cholangiopancreatography for the diagnosis of biliary atresia in infants and neonates publication-title: PLoS One – volume: 8 start-page: 1471 year: 2016 end-page: 1477 article-title: Elevation of serum urokinase plasminogen activator receptor and liver stiffness in postoperative biliary atresia publication-title: World J Hepatol – volume: 35 start-page: 1475 year: 2016 end-page: 1479 article-title: Utility of shear wave elastography for differentiating biliary atresia from infantile hepatitis syndrome publication-title: J Ultrasound Med – volume: 121 start-page: 4244 year: 2011 end-page: 4256 article-title: Th2 signals induce epithelial injury in mice and are compatible with the biliary atresia phenotype publication-title: J Clin Invest – volume: 53 start-page: 202 year: 2011 end-page: 208 article-title: Effects of the infant stool color card screening program on 5‐year outcome of biliary atresia in Taiwan publication-title: Hepatology – volume: 42 start-page: 2093 year: 2007 end-page: 2096 article-title: Can biliary atresia be diagnosed by ultrasonography alone? publication-title: J Pediatr Surg – volume: 14 start-page: 3862 year: 2015 end-page: 3868 article-title: Effect of different time phases of radionuclide hepatobiliary scintigraphy on the differential diagnosis of congenital biliary atresia publication-title: Genet Mol Res – volume: 60 start-page: 211 year: 2014 end-page: 223 article-title: Gene expression signature for biliary atresia and a role for interleukin‐8 in pathogenesis of experimental disease publication-title: Hepatology – volume: 374 start-page: 1704 year: 2009 end-page: 1713 article-title: Biliary atresia publication-title: Lancet – volume: 32 start-page: 1557 year: 2012 end-page: 1563 article-title: A high serum interleukin‐12p40 level prior to Kasai surgery predict a favorable outcome in children with biliary atresia publication-title: Liver Int – volume: 170 start-page: 211 year: 2016 end-page: 217 article-title: Total serum bilirubin within 3 months of hepatoportoenterostomy predicts short‐term outcomes in biliary atresia publication-title: J Pediatr – volume: 67 start-page: 345 year: 2010 end-page: 351 article-title: Macrophages are targeted by rotavirus in experimental biliary atresia and induce neutrophil chemotaxis by Mip2/Cxcl2 publication-title: Pediatr Res – volume: 42 start-page: 2093 year: 2007 ident: hep29856-bib-0011-20241017 article-title: Can biliary atresia be diagnosed by ultrasonography alone? publication-title: J Pediatr Surg doi: 10.1016/j.jpedsurg.2007.08.032 – volume: 43 start-page: 659 year: 2011 ident: hep29856-bib-0029-20241017 article-title: Non‐invasive methods can predict oesophageal varices in patients with biliary atresia after a Kasai procedure publication-title: Dig Liver Dis doi: 10.1016/j.dld.2011.04.006 – volume: 53 start-page: 202 year: 2011 ident: hep29856-bib-0007-20241017 article-title: Effects of the infant stool color card screening program on 5‐year outcome of biliary atresia in Taiwan publication-title: Hepatology doi: 10.1002/hep.24023 – volume: 37 start-page: 4 year: 2003 ident: hep29856-bib-0006-20241017 article-title: Pathogenesis and outcome of biliary atresia: current concepts publication-title: J Pediatr Gastroenterol Nutr – volume: 52 start-page: 871 year: 2015 ident: hep29856-bib-0009-20241017 article-title: Recent trends in the diagnosis and management of biliary atresia in developing countries publication-title: Indian Pediatr doi: 10.1007/s13312-015-0735-6 – volume: 67 start-page: 345 year: 2010 ident: hep29856-bib-0026-20241017 article-title: Macrophages are targeted by rotavirus in experimental biliary atresia and induce neutrophil chemotaxis by Mip2/Cxcl2 publication-title: Pediatr Res doi: 10.1203/PDR.0b013e3181d22a73 – volume: 13 start-page: 265 year: 1983 ident: hep29856-bib-0004-20241017 article-title: Advances in treatment of biliary atresia publication-title: Jpn J Surg doi: 10.1007/BF02469507 – volume: 30 start-page: 69 year: 2000 ident: hep29856-bib-0010-20241017 article-title: Making the diagnosis of biliary atresia using the triangular cord sign and gallbladder length publication-title: Pediatr Radiol doi: 10.1007/s002470050017 – volume: 11 start-page: e0158132 year: 2016 ident: hep29856-bib-0013-20241017 article-title: Incremental value of MR cholangiopancreatography in diagnosis of biliary atresia publication-title: PLoS One doi: 10.1371/journal.pone.0158132 – volume: 39 start-page: 891 year: 2004 ident: hep29856-bib-0001-20241017 article-title: Biliary Atresia Research Consortium (BARC) publication-title: Hepatology doi: 10.1002/hep.20185 – volume: 11 start-page: 41 year: 2011 ident: hep29856-bib-0018-20241017 article-title: Transient elastography for predicting esophageal/gastric varices in children with biliary atresia publication-title: BMC Gastroenterol doi: 10.1186/1471-230X-11-41 – volume: 35 start-page: 1475 year: 2016 ident: hep29856-bib-0019-20241017 article-title: Utility of shear wave elastography for differentiating biliary atresia from infantile hepatitis syndrome publication-title: J Ultrasound Med doi: 10.7863/ultra.15.08031 – volume: 8 start-page: 1471 year: 2016 ident: hep29856-bib-0017-20241017 article-title: Elevation of serum urokinase plasminogen activator receptor and liver stiffness in postoperative biliary atresia publication-title: World J Hepatol doi: 10.4254/wjh.v8.i33.1471 – volume: 170 start-page: 211 year: 2016 ident: hep29856-bib-0021-20241017 article-title: Total serum bilirubin within 3 months of hepatoportoenterostomy predicts short‐term outcomes in biliary atresia publication-title: J Pediatr doi: 10.1016/j.jpeds.2015.11.058 – volume: 24 start-page: 289 year: 1996 ident: hep29856-bib-0020-20241017 article-title: An algorithm for the grading of activity in chronic hepatitis C. The METAVIR Cooperative Study Group publication-title: Hepatology doi: 10.1002/hep.510240201 – volume: 32 start-page: 1557 year: 2012 ident: hep29856-bib-0024-20241017 article-title: A high serum interleukin‐12p40 level prior to Kasai surgery predict a favorable outcome in children with biliary atresia publication-title: Liver Int doi: 10.1111/liv.12001 – volume: 374 start-page: 1704 year: 2009 ident: hep29856-bib-0003-20241017 article-title: Biliary atresia publication-title: Lancet doi: 10.1016/S0140-6736(09)60946-6 – volume: 4 start-page: 779 year: 2000 ident: hep29856-bib-0005-20241017 article-title: Biliary atresia. A surgical perspective publication-title: Clin Liver Dis doi: 10.1016/S1089-3261(05)70141-0 – volume: 14 start-page: 3862 year: 2015 ident: hep29856-bib-0015-20241017 article-title: Effect of different time phases of radionuclide hepatobiliary scintigraphy on the differential diagnosis of congenital biliary atresia publication-title: Genet Mol Res doi: 10.4238/2015.April.22.15 – volume: 121 start-page: 4244 year: 2011 ident: hep29856-bib-0023-20241017 article-title: Th2 signals induce epithelial injury in mice and are compatible with the biliary atresia phenotype publication-title: J Clin Invest doi: 10.1172/JCI57728 – volume: 119 start-page: 2281 year: 2009 ident: hep29856-bib-0025-20241017 article-title: Neonatal NK cells target the mouse duct epithelium via Nkg2d and drive tissue‐specific injury in experimental biliary atresia publication-title: J Clin Invest doi: 10.1172/JCI38879 – volume: 206 start-page: W73 year: 2016 ident: hep29856-bib-0012-20241017 article-title: Ultrasound for the diagnosis of biliary atresia: a meta‐analysis publication-title: AJR Am J Roentgenol doi: 10.2214/AJR.15.15336 – volume: 12 start-page: e0182089 year: 2017 ident: hep29856-bib-0028-20241017 article-title: Cxcr2 signaling and the microbiome suppress inflammation, bile duct injury, and the phenotype of experimental biliary atresia publication-title: PLoS One doi: 10.1371/journal.pone.0182089 – volume: 9 start-page: e88268 year: 2014 ident: hep29856-bib-0014-20241017 article-title: Three‐dimensional magnetic resonance cholangiopancreatography for the diagnosis of biliary atresia in infants and neonates publication-title: PLoS One doi: 10.1371/journal.pone.0088268 – volume: 21 start-page: 6931 year: 2015 ident: hep29856-bib-0016-20241017 article-title: Assessment of liver fibrosis by Fibroscan as compared to liver biopsy in biliary atresia publication-title: World J Gastroenterol doi: 10.3748/wjg.v21.i22.6931 – volume: 46 start-page: 566 year: 2007 ident: hep29856-bib-0002-20241017 article-title: Screening and outcomes in biliary atresia: summary of a National Institutes of Health workshop publication-title: Hepatology doi: 10.1002/hep.21790 – volume: 12 start-page: e0176275 year: 2017 ident: hep29856-bib-0008-20241017 article-title: Initial assessment of the infant with neonatal cholestasis—is this biliary atresia? publication-title: PLoS One doi: 10.1371/journal.pone.0176275 – volume: 60 start-page: 211 year: 2014 ident: hep29856-bib-0022-20241017 article-title: Gene expression signature for biliary atresia and a role for interleukin‐8 in pathogenesis of experimental disease publication-title: Hepatology doi: 10.1002/hep.27045 – volume: 133 start-page: 268 year: 2007 ident: hep29856-bib-0027-20241017 article-title: Effector role of neonatal hepatic CD8+ lymphocytes in epithelial injury and autoimmunity in experimental biliary atresia publication-title: Gastroenterology doi: 10.1053/j.gastro.2007.04.031 |
| SSID | ssj0009428 |
| Score | 2.5046308 |
| Snippet | We investigated the utility of transient elastography (TE) for diagnosing biliary atresia (BA) in cholestatic infants and predicting the outcome of BA.... |
| SourceID | proquest pubmed crossref wiley |
| SourceType | Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 616 |
| SubjectTerms | Biliary atresia Bilirubin Cholestasis Esophagus Fibrosis Infants Liver Liver transplantation Splenomegaly Thrombocytopenia |
| Title | Transient elastography is useful in diagnosing biliary atresia and predicting prognosis after hepatoportoenterostomy |
| URI | https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fhep.29856 https://www.ncbi.nlm.nih.gov/pubmed/29486516 https://www.proquest.com/docview/2086341897 https://www.proquest.com/docview/2009214880 |
| Volume | 68 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1La9wwEB5CDqWXpk0f2TYNauhhL97VypJjkVMoCUshpYQu7CFgZFmiS7feJbYP7a_vjPwIaRIovRk0lmWPRvONNfMJ4CPHhlS6mNIqikhqpyLtcoN2ZXMplTLSUO3w5ZdkvpCfl2q5A6d9LUzLDzH8cCPLCOs1GbjJq-ktaeh3t50InSqi26ZcLQJEV7fUUVqGc1Ux6uK0u6x7ViEupsOdd33RPYB5F68Gh3OxB9f9UNs8kx-Tps4n9vdfLI7_-S7P4VkHRNlZO3NewI4r9-HJZbfV_hLq4MWoWpI5RNh1R23NVhVrKuebNVuVrGgT9dD9MUqyxQEwQ8UnK8NMWbDtDXVHidWM8sBIsmLhVHKGY8Fwn8D_hlhBqfZk8_PXK1hcnH_7NI-6IxoiG6s4iXJUJgZAjngJuSoQXAphZ94nhTdKCsdPEiedR2zMTZpw7wyRyxiT-DyJC2_j17Bbbkp3AIwjEvTK2tyKGGPUIuU4vYjN0GlfoDZHMO6VldmOv5yO0VhnLfOyyHDkWfiKIzgeRLctacdDQoe9xrPObqtMYISHfj3VJyP4MDSjxdE2iindpiEZrsWMFr4RvGlnyvAUoWWaqBl2Pg76fvzx2fz8a7h4---i7-Ap4rW0zT88hN36pnHvERPV-VGY_H8AAtoKoQ |
| linkProvider | Wiley-Blackwell |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LT9wwEB5RKtFeoA8oWyh1EQcuWYxjh1jighBoaVmEEEhcUOQ4trpqm12x2QP8-s44DwS0UtVbpEwcJ-PJfBPPfAOwxfFEKl1MaRVFJLVTkXa5QbuyuZRKGWmodnh4lgyu5NdrdT0H-20tTM0P0f1wI8sI32sycPohvfPAGvrdTfpCpyp5AS-po3cIqC4eyKO0DJ1VMe7itL-sW14hLna6Sx97o2cQ8zFiDS7neAlu2snWmSY_-rMq79v7JzyO__s0b2CxwaLsoF48b2HOle9gYdjstr-HKjgyKphkDkF21bBbs9GUzaYOR2ajkhV1rh56QEZ5tjgDZqj-ZGSYKQs2uaXhKLeaUSoYSU5ZaEzOcC4Y8RP-HxMxKJWfjH_dLcPV8dHl4SBqujRENlZxEuWoT4yBHFETclUgvhTC7nqfFN4oKRzfS5x0HuExN2nCvTPEL2NM4vMkLryNV2C-HJduFRhHMOiVtbkVMYapRcpxhRGhodO-QHX2YLvVVmYbCnPqpPEzq8mXRYYzz8Jb7MFmJzqpeTv-JLTeqjxrTHeaCQzy0LWneq8HX7rTaHS0k2JKN56RDNdil759PfhQL5XuLkLLFFcjDr4dFP7322eDo_Nw8PHfRT_Dq8Hl8DQ7PTn7tgavEb6ldTriOsxXtzP3CSFSlW8ES_gNkucOvA |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwEB6VIlVcoLzKQgsGceglW69ju7E4VW1Xy6NVhajUA1LkxLZYUbKrbnKAX8-M86jKQ0LcInniOBmP55t45jPAa44NmfQppVW4RBqvEuMLi3ZVFlIqZaWl2uGTUz07l-8u1MUavOlrYVp-iOGHG1lGXK_JwJcu7F2Thn7xy7EwmdK34LbUPKMpffTxmjvKyHiwKoZdnLaXTU8rxMXecOtNZ_QbwrwJWKPHmd6Dz_1Y20STr-OmLsblj19oHP_zZTbhbodE2UE7de7Dmq8ewMZJt9f-EOroxqhcknmE2HXHbc3mK9asfGgu2bxirs3UQ__HKMsWB8AsVZ_MLbOVY8sr6o4yqxklgpHkisVjyRmOBeN9Qv8LogWl4pPFt--P4Hx6_OlwlnRnNCRlqlKdFKhNjIA8ERNy5RBdClFOQtAuWCWF5_vaSx8QHHObaR68JXYZa3UodOpCmT6G9WpR-SfAOELBoMqyKEWKQarLOM4vojP0JjjU5gh2e2XlZUdgTudoXOYt9bLIceR5_IojeDWILlvWjj8JbfcazzvDXeUCQzx07JnZH8HLoRlNjvZRbOUXDclwIya08o1gq50pw1OEkZlWE-x8N-r774_PZ8dn8eLpv4u-gI2zo2n-4e3p-2dwB7Fb1uYibsN6fdX4HcRHdfE82sFPg1gNdA |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Transient+elastography+is+useful+in+diagnosing+biliary+atresia+and+predicting+prognosis+after+hepatoportoenterostomy&rft.jtitle=Hepatology+%28Baltimore%2C+Md.%29&rft.au=Wu%2C+Jia-Feng&rft.au=Lee%2C+Chee-Seng&rft.au=Lin%2C+Wen-Hsi&rft.au=Jeng%2C+Yung-Ming&rft.date=2018-08-01&rft.eissn=1527-3350&rft.volume=68&rft.issue=2&rft.spage=616&rft_id=info:doi/10.1002%2Fhep.29856&rft_id=info%3Apmid%2F29486516&rft.externalDocID=29486516 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0270-9139&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0270-9139&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0270-9139&client=summon |