Effect of CCNB1 silencing on cell cycle, senescence, and apoptosis through the p53 signaling pathway in pancreatic cancer

• Published in: Journal of cellular physiology Vol. 234; no. 1; pp. 619 - 631
• Main Authors: Zhang, Hui, Zhang, Xuan, Li, Xun, Meng, Wen‐Bo, Bai, Zhong‐Tian, Rui, Shao‐Zhen, Wang, Zheng‐Feng, Zhou, Wen‐Ce, Jin, Xiao‐Da
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.01.2019
• Subjects: Apoptosis; Cancer; Caspase; CCNB1; Cell activation; Cell cycle; Cell proliferation; Cyclin B1; Cyclin-dependent kinase inhibitor p21; Flow cytometry; Galactosidase; gene silencing; Malignancy; MDM2 protein; Metastases; p53 Protein; p53 signaling pathway; Pancreatic cancer; Pathogenesis; Polymerase chain reaction; Reverse transcription; Senescence; Signal transduction; Signaling; β-Galactosidase; senescence; CCNB1; pancreatic cancer; p53 signaling pathway; cell cycle; gene silencing; apoptosis

Pancreatic cancer (PC) is a serious malignancy with high mortality and poor prognosis due to nonspecific incipient symptoms and early metastasis. Also, increasing evidence indicates that a panel of genes is newly identified in the pathogenesis of PC. As is a regulatory subunit, elevated cyclin B1 (C...