Brain mitochondrial impairment in early‐onset Parkinson's disease with or without PINK1 mutation

• Published in: Movement disorders Vol. 35; no. 3; pp. 504 - 507
• Main Authors: Rango, Mario, Dossi, Gabriele, Squarcina, Letizia, Bonifati, Cristiana
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.03.2020; Wiley Subscription Services, Inc
• Subjects: Adenosine triphosphate; Age of Onset; Brain - diagnostic imaging; brain mitochondrial functioning; brain pH; early‐onset Parkinson's disease (EOPD); Humans; Intracellular; Magnetic resonance spectroscopy; Mitochondria; Mitochondria - genetics; Movement disorders; Mutation; Mutation - genetics; Neurodegenerative diseases; Parkinson Disease - complications; Parkinson Disease - genetics; Parkinson's disease; pH effects; Phosphocreatine; phosphorus magnetic resonance spectroscopy (MRS); PINK1 gene mutation; Protein Kinases - genetics; PTEN-induced putative kinase; brain pH; brain mitochondrial functioning; phosphorus magnetic resonance spectroscopy (MRS); early-onset Parkinson's disease (EOPD); PINK1 gene mutation

Background PINK1 mutations are likely to affect mitochondrial function. The objective of this study was to study brain mitochondrial function in patients with early‐onset Parkinson's disease, with or without PINK1 mutations. Methods We investigated brain intracellular pH, mitochondrial activity...