Multiple sessions of therapeutic electrical stimulation using implantable thin‐film wireless nerve stimulators improve functional recovery after sciatic nerve isograft repair

• Published in: Muscle & nerve Vol. 67; no. 3; pp. 244 - 251
• Main Authors: Birenbaum, Nathan K., Yan, Ying, Odabas, Arman, Chandra, Nikhil S., Ray, Wilson Z., MacEwan, Matthew R.
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.03.2023; Wiley Subscription Services, Inc
• Subjects: Action potential; Animals; Axon sprouting; Axons; Electric Stimulation; Electric Stimulation Therapy; Electrical stimuli; Isografts; Male; Muscle, Skeletal - physiology; Muscles; nerve graft; nerve regeneration; Nerve Regeneration - physiology; Optimization; peripheral nerve injury; Peripheral nerves; Rats; Rats, Inbred Lew; Recovery; Recovery of function; Recovery of Function - physiology; Regeneration; repetitive nerve stimulation; Sciatic nerve; Sciatic Nerve - surgery; Stimulation; Stimulators; Surgery; therapeutic electrical stimulation; Thin films; Transplants & implants; wireless nerve stimulator; nerve regeneration; peripheral nerve injury; therapeutic electrical stimulation; nerve graft; wireless nerve stimulator; repetitive nerve stimulation

Introduction/Aims Although therapeutic electrical stimulation (TES) of injured peripheral nerve promotes axon regeneration and functional recovery, clinical applications of this therapy are limited to the intraoperative timeframe. Implantable, thin‐film wireless nerve stimulators offer a potential s...