Engineered human cardiac microtissues: The state‐of‐the‐(he)art

Due to the integration of recent advances in stem cell biology, materials science, and engineering, the field of cardiac tissue engineering has been rapidly progressing toward developing more accurate functional 3D cardiac microtissues from human cell sources. These engineered tissues enable screeni...

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Bibliographic Details
Published inStem cells (Dayton, Ohio) Vol. 39; no. 8; pp. 1008 - 1016
Main Authors Soon, Kayla, Mourad, Omar, Nunes, Sara S.
Format Journal Article
LanguageEnglish
Published Hoboken, USA John Wiley & Sons, Inc 01.08.2021
Oxford University Press
Subjects
cardiac
Cardiomyocytes
Drug development
Drug screening
Environmental conditions
Humans
Materials science
Myocytes, Cardiac
Stem Cells
stem/progenitor cell
technology
Tissue Engineering
tissue engineering
technology
stem/progenitor cell
cardiac
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Summary:Due to the integration of recent advances in stem cell biology, materials science, and engineering, the field of cardiac tissue engineering has been rapidly progressing toward developing more accurate functional 3D cardiac microtissues from human cell sources. These engineered tissues enable screening of cardiotoxic drugs, disease modeling (eg, by using cells from specific genetic backgrounds or modifying environmental conditions) and can serve as novel drug development platforms. This concise review presents the most recent advances and improvements in cardiac tissue formation, including cardiomyocyte maturation and disease modeling. Recent advances in cardiac microtissue engineering with a focus on approaches to recapitulate the adult heart and model disease phenotype. The microtissue platform depicted may not be representative of platform used in selected publication and is only a generalization.
Bibliography:Funding information
Kayla Soon and Omar Mourad contributed equally to this study.
University of Toronto; NSERC CREATE TOeP scholarship; Mount Sinai Hospital Graduate Scholarship in Science and Technology; Natural Sciences and Engineering Research Council of Canada, Grant/Award Number: RGPIN 06621‐2017; Canadian Institutes of Health Research, Grant/Award Number: PJT153160
ISSN:1066-5099
1549-4918
DOI:10.1002/stem.3376