DNA methylation patterns of genes related to immune response in the different clinical forms of oral lichen planus
Background The oral lichen planus is a chronic inflammatory disease. Although its aetiology is not well understood, the role of T lymphocytes in its inflammatory events is recognised. Identifying the epigenetic mechanisms involved in the pathogenesis of this immune‐mediated condition is fundamental...
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Published in | Journal of oral pathology & medicine Vol. 47; no. 1; pp. 91 - 95 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
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01.01.2018
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Abstract | Background
The oral lichen planus is a chronic inflammatory disease. Although its aetiology is not well understood, the role of T lymphocytes in its inflammatory events is recognised. Identifying the epigenetic mechanisms involved in the pathogenesis of this immune‐mediated condition is fundamental for understanding the inflammatory reaction that occurs in the disease. The purpose of this work was to evaluate the methylation pattern of 21 immune response‐related genes in the different clinical forms of oral lichen planus.
Methods
A cross‐sectional study was performed to analyse the DNA methylation patterns in three distinct groups of oral lichen planus: (i) reticular/plaque lesions; (ii) erosive lesions; (iii) normal oral mucosa (control group). After DNA extraction from biopsies, the samples were submitted to digestions by methylation‐sensitive and methylation‐dependent enzymes and double digestion. The relative percentage of methylated DNA for each gene was provided using real‐time polymerase chain reaction arrays.
Results
Hypermethylation of the STAT5A gene was observed only in the control group (59.0%). A higher hypermethylation of the ELANE gene was found in reticular/plaque lesions (72.1%) compared to the erosive lesions (50.0%).
Conclusion
Our results show variations in the methylation profile of immune response‐related genes, according to the clinical type of oral lichen planus after comparing with the normal oral mucosa. Further studies are necessary to validate these findings using gene expression analysis. |
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AbstractList | Background The oral lichen planus is a chronic inflammatory disease. Although its aetiology is not well understood, the role of T lymphocytes in its inflammatory events is recognised. Identifying the epigenetic mechanisms involved in the pathogenesis of this immune-mediated condition is fundamental for understanding the inflammatory reaction that occurs in the disease. The purpose of this work was to evaluate the methylation pattern of 21 immune response-related genes in the different clinical forms of oral lichen planus. Methods A cross-sectional study was performed to analyse the DNA methylation patterns in three distinct groups of oral lichen planus: (i) reticular/plaque lesions; (ii) erosive lesions; (iii) normal oral mucosa (control group). After DNA extraction from biopsies, the samples were submitted to digestions by methylation-sensitive and methylation-dependent enzymes and double digestion. The relative percentage of methylated DNA for each gene was provided using real-time polymerase chain reaction arrays. Results Hypermethylation of the STAT5A gene was observed only in the control group (59.0%). A higher hypermethylation of the ELANE gene was found in reticular/plaque lesions (72.1%) compared to the erosive lesions (50.0%). Conclusion Our results show variations in the methylation profile of immune response-related genes, according to the clinical type of oral lichen planus after comparing with the normal oral mucosa. Further studies are necessary to validate these findings using gene expression analysis. The oral lichen planus is a chronic inflammatory disease. Although its aetiology is not well understood, the role of T lymphocytes in its inflammatory events is recognised. Identifying the epigenetic mechanisms involved in the pathogenesis of this immune-mediated condition is fundamental for understanding the inflammatory reaction that occurs in the disease. The purpose of this work was to evaluate the methylation pattern of 21 immune response-related genes in the different clinical forms of oral lichen planus. A cross-sectional study was performed to analyse the DNA methylation patterns in three distinct groups of oral lichen planus: (i) reticular/plaque lesions; (ii) erosive lesions; (iii) normal oral mucosa (control group). After DNA extraction from biopsies, the samples were submitted to digestions by methylation-sensitive and methylation-dependent enzymes and double digestion. The relative percentage of methylated DNA for each gene was provided using real-time polymerase chain reaction arrays. Hypermethylation of the STAT5A gene was observed only in the control group (59.0%). A higher hypermethylation of the ELANE gene was found in reticular/plaque lesions (72.1%) compared to the erosive lesions (50.0%). Our results show variations in the methylation profile of immune response-related genes, according to the clinical type of oral lichen planus after comparing with the normal oral mucosa. Further studies are necessary to validate these findings using gene expression analysis. Background The oral lichen planus is a chronic inflammatory disease. Although its aetiology is not well understood, the role of T lymphocytes in its inflammatory events is recognised. Identifying the epigenetic mechanisms involved in the pathogenesis of this immune‐mediated condition is fundamental for understanding the inflammatory reaction that occurs in the disease. The purpose of this work was to evaluate the methylation pattern of 21 immune response‐related genes in the different clinical forms of oral lichen planus. Methods A cross‐sectional study was performed to analyse the DNA methylation patterns in three distinct groups of oral lichen planus: (i) reticular/plaque lesions; (ii) erosive lesions; (iii) normal oral mucosa (control group). After DNA extraction from biopsies, the samples were submitted to digestions by methylation‐sensitive and methylation‐dependent enzymes and double digestion. The relative percentage of methylated DNA for each gene was provided using real‐time polymerase chain reaction arrays. Results Hypermethylation of the STAT 5A gene was observed only in the control group (59.0%). A higher hypermethylation of the ELANE gene was found in reticular/plaque lesions (72.1%) compared to the erosive lesions (50.0%). Conclusion Our results show variations in the methylation profile of immune response‐related genes, according to the clinical type of oral lichen planus after comparing with the normal oral mucosa. Further studies are necessary to validate these findings using gene expression analysis. BACKGROUNDThe oral lichen planus is a chronic inflammatory disease. Although its aetiology is not well understood, the role of T lymphocytes in its inflammatory events is recognised. Identifying the epigenetic mechanisms involved in the pathogenesis of this immune-mediated condition is fundamental for understanding the inflammatory reaction that occurs in the disease. The purpose of this work was to evaluate the methylation pattern of 21 immune response-related genes in the different clinical forms of oral lichen planus.METHODSA cross-sectional study was performed to analyse the DNA methylation patterns in three distinct groups of oral lichen planus: (i) reticular/plaque lesions; (ii) erosive lesions; (iii) normal oral mucosa (control group). After DNA extraction from biopsies, the samples were submitted to digestions by methylation-sensitive and methylation-dependent enzymes and double digestion. The relative percentage of methylated DNA for each gene was provided using real-time polymerase chain reaction arrays.RESULTSHypermethylation of the STAT5A gene was observed only in the control group (59.0%). A higher hypermethylation of the ELANE gene was found in reticular/plaque lesions (72.1%) compared to the erosive lesions (50.0%).CONCLUSIONOur results show variations in the methylation profile of immune response-related genes, according to the clinical type of oral lichen planus after comparing with the normal oral mucosa. Further studies are necessary to validate these findings using gene expression analysis. Background The oral lichen planus is a chronic inflammatory disease. Although its aetiology is not well understood, the role of T lymphocytes in its inflammatory events is recognised. Identifying the epigenetic mechanisms involved in the pathogenesis of this immune‐mediated condition is fundamental for understanding the inflammatory reaction that occurs in the disease. The purpose of this work was to evaluate the methylation pattern of 21 immune response‐related genes in the different clinical forms of oral lichen planus. Methods A cross‐sectional study was performed to analyse the DNA methylation patterns in three distinct groups of oral lichen planus: (i) reticular/plaque lesions; (ii) erosive lesions; (iii) normal oral mucosa (control group). After DNA extraction from biopsies, the samples were submitted to digestions by methylation‐sensitive and methylation‐dependent enzymes and double digestion. The relative percentage of methylated DNA for each gene was provided using real‐time polymerase chain reaction arrays. Results Hypermethylation of the STAT5A gene was observed only in the control group (59.0%). A higher hypermethylation of the ELANE gene was found in reticular/plaque lesions (72.1%) compared to the erosive lesions (50.0%). Conclusion Our results show variations in the methylation profile of immune response‐related genes, according to the clinical type of oral lichen planus after comparing with the normal oral mucosa. Further studies are necessary to validate these findings using gene expression analysis. |
Author | Diniz, Marina Gonçalves Pereira, Núbia Braga Gomez, Ricardo Santiago Resende, Renata Gonçalves Lacerda, Júlio César Tanos Melo, Leonardo Augusto Cruz, Aline Fernanda Gomes, Carolina Cavalieri |
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Cites_doi | 10.1038/ncponc0354 10.1111/odi.12243 10.1016/j.joen.2012.12.026 10.1034/j.1600-0714.2003.00127.x 10.1136/lupus-2015-000101 10.1038/nrg3354 10.4049/jimmunol.137.1.35 10.1016/j.molimm.2014.02.018 10.1371/journal.pone.0044213 10.1067/moe.2001.110415 10.1155/2015/283465 10.1111/jop.12012 10.1016/j.cden.2004.08.004 10.1158/0008-5472.CAN-07-5194 10.1038/nature05913 10.3892/mmr.2014.1919 10.2334/josnusd.49.89 10.1165/rcmb.2013-0338RC 10.1038/ni1455 10.1016/0198-8859(86)90304-6 10.1016/j.oooo.2016.05.004 10.1111/j.1600-0528.1987.tb00480.x 10.1016/j.tips.2010.08.001 10.1016/j.jcms.2015.07.028 10.1002/hed.21949 10.1016/j.autrev.2015.05.008 10.1038/nri2580 |
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References | 2001; 91 2015; 2 2010; 31 2015; 14 2007; 447 1986; 137 2015; 145 2013; 42 1986; 17 2016; 122 2005; 49 2012; 34 2003; 32 1987; 15 2014; 20 2013; 14 2013; 39 2017; 17 2015; 43 2015; 2015 2007; 8 2014; 59 2009; 9 2017 2008; 68 2005; 2 2014; 9 2012; 7 2014; 50 2007; 49 e_1_2_7_4_1 e_1_2_7_3_1 Cheng YL (e_1_2_7_18_1) 2016; 122 e_1_2_7_9_1 e_1_2_7_8_1 e_1_2_7_7_1 e_1_2_7_19_1 Chen J (e_1_2_7_23_1) 2017; 17 e_1_2_7_16_1 e_1_2_7_2_1 e_1_2_7_15_1 Richardson B (e_1_2_7_29_1) 1986; 137 e_1_2_7_14_1 e_1_2_7_13_1 e_1_2_7_12_1 e_1_2_7_11_1 Leoni C (e_1_2_7_20_1) 2015; 145 e_1_2_7_10_1 e_1_2_7_26_1 e_1_2_7_27_1 e_1_2_7_28_1 Rossi SS (e_1_2_7_6_1) 2005; 49 Bjanesoya TE (e_1_2_7_17_1) 2014; 59 e_1_2_7_30_1 e_1_2_7_25_1 e_1_2_7_31_1 e_1_2_7_24_1 e_1_2_7_22_1 e_1_2_7_21_1 El‐Naggar AK (e_1_2_7_5_1) 2017 |
References_xml | – volume: 49 start-page: 77 year: 2005 end-page: 89 article-title: Lichen planus, lichenoid drug reactions and lichenoid mucositis publication-title: Dent Clin North Am – volume: 145 start-page: 1419 year: 2015 article-title: Epigenetics of T lymphocytes in health and disease publication-title: Swiss Med Wkly – volume: 91 start-page: 180 year: 2001 end-page: 188 article-title: Peripheral T‐cell subsets in patients with reticular and atrophic‐erosive oral lichen planus publication-title: Oral Surg Oral Med Oral Pathol Oral Radiol Endod – volume: 68 start-page: 2094 year: 2008 end-page: 2105 article-title: Exploration of tumor‐suppressive microRNAs silenced by DNA hypermethylation in oral cancer publication-title: Cancer Res – volume: 15 start-page: 52 year: 1987 end-page: 56 article-title: Oral lichen planus – a demographic study publication-title: Community Dent Oral Epidemiol – volume: 43 start-page: 1494 year: 2015 end-page: 1500 article-title: DNA methylation analysis by bisulfite next‐generation sequencing for early detection of oral squamous cell carcinoma and high‐grade squamous intraepithelial lesion from oral brushing publication-title: J Craniomaxillofac Surg – volume: 17 start-page: S2212 year: 2017 end-page: S4403 article-title: Integrative analysis of mRNA and miRNA expression profiles in oral lichen planus: preliminary results publication-title: Oral Surg Oral Med Oral Pathol Oral Radiol – volume: 9 start-page: 480 year: 2009 article-title: New insights into the regulation of T cells by γc family cytokines publication-title: Nat Rev Immunol – volume: 7 start-page: e44213 year: 2012 article-title: DNA methylation profiles of airway epithelial cells and PBMCs from healthy, atopic and asthmatic children publication-title: PLoS ONE – volume: 32 start-page: 271 year: 2003 end-page: 274 article-title: Phagocytic functions of salivary neutrophils in oral mucous membrane diseases publication-title: J Oral Pathol Med – volume: 8 start-page: 457 year: 2007 end-page: 462 article-title: Foxp3 in control of the regulatory T cell lineage publication-title: Nat Immunol – volume: 2015 start-page: 1 year: 2015 end-page: 5 article-title: Quantitative analysis of salivary TFN‐α in oral lichen planus patients publication-title: Int J Dent – volume: 447 start-page: 396 year: 2007 end-page: 398 article-title: Perceptions of epigenetics publication-title: Nature – volume: 14 start-page: 204 year: 2013 end-page: 220 article-title: DNA methylation: roles in mammalian development publication-title: Nat Rev Genet – volume: 137 start-page: 35 year: 1986 end-page: 39 article-title: Effect of an inhibitor of DNA methylation on T cells. I. 5‐Azacytidine induces T4 expression on T8 + T cells publication-title: J Immunol – volume: 2 start-page: 4 year: 2005 end-page: 11 article-title: DNA methylation and gene silencing in cancer publication-title: Nat Rev Clin Oncol – volume: 20 start-page: 821 year: 2014 end-page: 826 article-title: Global DNA methylation: uncommon event in oral lichenoid disease publication-title: Oral Dis – volume: 17 start-page: 456 year: 1986 end-page: 470 article-title: Effect of an inhibitor of DNA methylation on T cells. II. 5‐Azacytidine induces selfreactivity in antigen‐specific T4 + cells publication-title: Hum Immunol – volume: 42 start-page: 315 year: 2013 end-page: 321 article-title: MicroRNA‐137 promoter methylation in oral lichen planus and oral squamous cell carcinoma publication-title: J Oral Pathol Med – volume: 31 start-page: 536 year: 2010 end-page: 546 article-title: Targeting DNA methylation for epigenetic therapy publication-title: Trends Pharmacol Sci – volume: 34 start-page: 1470 year: 2012 end-page: 1475 article-title: Promoter methylation and loss of p16(INK4a) gene expression in head and neck cancer publication-title: Head Neck – volume: 50 start-page: 684 year: 2014 end-page: 689 article-title: 2‐O, 3‐O‐desulfated heparin inhibits neutrophil elastase‐induced HMGB‐1 secretion and airway inflammation publication-title: Am J Respir Cell Mol Biol – volume: 2 start-page: e000101 year: 2015 article-title: DNA methylation patterns in naïve CD4 + T cells identify epigenetic susceptibility loci for malar rash and discoid rash in systemic lúpus erythematosus publication-title: Lupus Sci Med – volume: 9 start-page: 928 year: 2014 end-page: 934 article-title: Foxp3 gene expression in oral lichen planus: a clinicopathological study publication-title: Mol Med Rep – volume: 49 start-page: 89 year: 2007 end-page: 106 article-title: Oral lichen planus and lichenoid reactions: etiopathogenesis, diagnosis, management and malignant transformation publication-title: J Oral Sci – year: 2017 – volume: 59 start-page: 208 year: 2014 end-page: 216 article-title: Altered DNA methylation profile in Norwegian patients with Autoimmune Addison's Disease publication-title: Mol Immunol – volume: 14 start-page: 854 year: 2015 end-page: 863 article-title: Epigenetics in autoimmune diseases: pathogenesis and prospects for therapy publication-title: Autoimmun Rev – volume: 122 start-page: 332 year: 2016 end-page: 354 article-title: Diagnosis of oral lichen planus: a position paper of the American Academy of Oral and Maxillofacial Pathology publication-title: Oral Surg Oral Pathol Oral Med – volume: 39 start-page: 493 year: 2013 end-page: 496 article-title: Methylation pattern of IFNG in periapical granulomas and radicular cysts publication-title: J Endod – ident: e_1_2_7_9_1 doi: 10.1038/ncponc0354 – ident: e_1_2_7_14_1 doi: 10.1111/odi.12243 – ident: e_1_2_7_15_1 doi: 10.1016/j.joen.2012.12.026 – ident: e_1_2_7_27_1 doi: 10.1034/j.1600-0714.2003.00127.x – volume: 145 start-page: 1419 year: 2015 ident: e_1_2_7_20_1 article-title: Epigenetics of T lymphocytes in health and disease publication-title: Swiss Med Wkly contributor: fullname: Leoni C – ident: e_1_2_7_16_1 doi: 10.1136/lupus-2015-000101 – ident: e_1_2_7_22_1 doi: 10.1038/nrg3354 – volume: 137 start-page: 35 year: 1986 ident: e_1_2_7_29_1 article-title: Effect of an inhibitor of DNA methylation on T cells. I. 5‐Azacytidine induces T4 expression on T8 + T cells publication-title: J Immunol doi: 10.4049/jimmunol.137.1.35 contributor: fullname: Richardson B – volume: 59 start-page: 208 year: 2014 ident: e_1_2_7_17_1 article-title: Altered DNA methylation profile in Norwegian patients with Autoimmune Addison's Disease publication-title: Mol Immunol doi: 10.1016/j.molimm.2014.02.018 contributor: fullname: Bjanesoya TE – ident: e_1_2_7_25_1 doi: 10.1371/journal.pone.0044213 – ident: e_1_2_7_3_1 doi: 10.1067/moe.2001.110415 – ident: e_1_2_7_4_1 doi: 10.1155/2015/283465 – ident: e_1_2_7_11_1 doi: 10.1111/jop.12012 – volume: 49 start-page: 77 year: 2005 ident: e_1_2_7_6_1 article-title: Lichen planus, lichenoid drug reactions and lichenoid mucositis publication-title: Dent Clin North Am doi: 10.1016/j.cden.2004.08.004 contributor: fullname: Rossi SS – ident: e_1_2_7_12_1 doi: 10.1158/0008-5472.CAN-07-5194 – ident: e_1_2_7_8_1 doi: 10.1038/nature05913 – ident: e_1_2_7_21_1 doi: 10.3892/mmr.2014.1919 – ident: e_1_2_7_7_1 doi: 10.2334/josnusd.49.89 – ident: e_1_2_7_26_1 doi: 10.1165/rcmb.2013-0338RC – ident: e_1_2_7_19_1 doi: 10.1038/ni1455 – ident: e_1_2_7_28_1 doi: 10.1016/0198-8859(86)90304-6 – volume: 122 start-page: 332 year: 2016 ident: e_1_2_7_18_1 article-title: Diagnosis of oral lichen planus: a position paper of the American Academy of Oral and Maxillofacial Pathology publication-title: Oral Surg Oral Pathol Oral Med doi: 10.1016/j.oooo.2016.05.004 contributor: fullname: Cheng YL – volume: 17 start-page: S2212 year: 2017 ident: e_1_2_7_23_1 article-title: Integrative analysis of mRNA and miRNA expression profiles in oral lichen planus: preliminary results publication-title: Oral Surg Oral Med Oral Pathol Oral Radiol contributor: fullname: Chen J – ident: e_1_2_7_2_1 doi: 10.1111/j.1600-0528.1987.tb00480.x – ident: e_1_2_7_30_1 doi: 10.1016/j.tips.2010.08.001 – ident: e_1_2_7_10_1 doi: 10.1016/j.jcms.2015.07.028 – ident: e_1_2_7_13_1 doi: 10.1002/hed.21949 – ident: e_1_2_7_31_1 doi: 10.1016/j.autrev.2015.05.008 – volume-title: WHO Classification of Head and Neck Tumours year: 2017 ident: e_1_2_7_5_1 contributor: fullname: El‐Naggar AK – ident: e_1_2_7_24_1 doi: 10.1038/nri2580 |
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The oral lichen planus is a chronic inflammatory disease. Although its aetiology is not well understood, the role of T lymphocytes in its... The oral lichen planus is a chronic inflammatory disease. Although its aetiology is not well understood, the role of T lymphocytes in its inflammatory events... Background The oral lichen planus is a chronic inflammatory disease. Although its aetiology is not well understood, the role of T lymphocytes in its... BACKGROUNDThe oral lichen planus is a chronic inflammatory disease. Although its aetiology is not well understood, the role of T lymphocytes in its... |
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SubjectTerms | Adolescent Adult Aged Cross-Sectional Studies Dentistry Deoxyribonucleic acid DNA DNA - analysis DNA - isolation & purification DNA Methylation epigenetic Epigenomics Female Gene Expression Humans Immune response Inflammation Lichen planus Lichen Planus, Oral - genetics Lichen Planus, Oral - immunology Lichen Planus, Oral - pathology Lymphocytes T Male methylation Middle Aged Mouth Mucosa Mucosa oral lichen planus Polymerase chain reaction Promoter Regions, Genetic STAT5 Transcription Factor - genetics T-Lymphocytes Tumor Suppressor Proteins - genetics Young Adult |
Title | DNA methylation patterns of genes related to immune response in the different clinical forms of oral lichen planus |
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