Angiotensin‐converting enzyme gene polymorphism and digestive system cancer risk: A meta‐analysis based on 9656 subjects

The angiotensin‐converting enzyme (ACE) is the major regulator of the renin‐angiotensin system, and it has been reported that genetic polymorphisms at this locus are associated with risk in numerous types of human cancers. In the current meta‐analysis, we aimed to evaluate the association between th...

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Published inJournal of cellular biochemistry Vol. 120; no. 12; pp. 19388 - 19395
Main Authors Abdeahad, Hossein, Avan, Amir, Khazaei, Majid, Soleimanpour, Saman, Ferns, Gordon A., Fiuji, Hamid, Ryzhikov, Mikhail, Bahrami, Afsane, Hassanian, Seyed Mahdi
Format Journal Article
LanguageEnglish
Published United States Wiley Subscription Services, Inc 01.12.2019
Subjects
ACE protein
Angiotensin
angiotensin‐converting enzyme
Cancer
Colorectal cancer
Colorectal carcinoma
Confidence intervals
Conversion
Digestive system
Enzymes
Gastric cancer
Gastrointestinal tract
Gene deletion
Gene polymorphism
Health risks
Insertion
Medical prognosis
Meta-analysis
Polymorphism
Renin
Renin‐angiotensin system
Risk analysis
Statistical analysis
Subgroups
colorectal cancer
gastric cancer
Renin-angiotensin system
angiotensin-converting enzyme
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Abstract The angiotensin‐converting enzyme (ACE) is the major regulator of the renin‐angiotensin system, and it has been reported that genetic polymorphisms at this locus are associated with risk in numerous types of human cancers. In the current meta‐analysis, we aimed to evaluate the association between the ACE Gene insertion/deletion (I/D) polymorphism (DD vs II) and digestive system cancer susceptibility. A total of 19 case‐control studies among 3722 patients with seven different types of cancer were included in this meta‐analysis. In the pooled analysis, the relationship between the ACE I/D polymorphism and digestive system cancer risk was not statistically significant (odds ratio [OR], 0.93; 95% confidence interval [CI], 0.68‐1.29; P = 0.65; random model). Furthermore, subgroup analyses by cancer type also did not reveal an association between ACE polymorphisms and colorectal cancer (OR, 1.14; 95% CI, 0.823‐1.58; P = 0.43; random effect model) and gastric cancer (OR, 0.79; 95% CI, 0.51‐1.22; P = 0.28; random effect model). These findings indicate that ACE polymorphisms in the digestive tract may still affect the survival of cancer patients, and future studies into the topic of effect of ACE on cancer prognosis are warranted. In the current meta‐analysis, we aimed to evaluate the association between the ACE Gene insertion/deletion (I/D) polymorphism (DD vs II) and digestive system cancer susceptibility. A total of 19 case‐control studies among 3722 patients with seven different types of cancer were included in this meta‐analysis. Our findings indicate that ACE polymorphisms in the digestive tract may still affect the survival of cancer patients, and future studies into the topic of effect of ACE on cancer prognosis are warranted.
AbstractList The angiotensin-converting enzyme (ACE) is the major regulator of the renin-angiotensin system, and it has been reported that genetic polymorphisms at this locus are associated with risk in numerous types of human cancers. In the current meta-analysis, we aimed to evaluate the association between the ACE Gene insertion/deletion (I/D) polymorphism (DD vs II) and digestive system cancer susceptibility. A total of 19 case-control studies among 3722 patients with seven different types of cancer were included in this meta-analysis. In the pooled analysis, the relationship between the ACE I/D polymorphism and digestive system cancer risk was not statistically significant (odds ratio [OR], 0.93; 95% confidence interval [CI], 0.68-1.29; P = 0.65; random model). Furthermore, subgroup analyses by cancer type also did not reveal an association between ACE polymorphisms and colorectal cancer (OR, 1.14; 95% CI, 0.823-1.58; P = 0.43; random effect model) and gastric cancer (OR, 0.79; 95% CI, 0.51-1.22; P = 0.28; random effect model). These findings indicate that ACE polymorphisms in the digestive tract may still affect the survival of cancer patients, and future studies into the topic of effect of ACE on cancer prognosis are warranted.
The angiotensin-converting enzyme (ACE) is the major regulator of the renin-angiotensin system, and it has been reported that genetic polymorphisms at this locus are associated with risk in numerous types of human cancers. In the current meta-analysis, we aimed to evaluate the association between the ACE Gene insertion/deletion (I/D) polymorphism (DD vs II) and digestive system cancer susceptibility. A total of 19 case-control studies among 3722 patients with seven different types of cancer were included in this meta-analysis. In the pooled analysis, the relationship between the ACE I/D polymorphism and digestive system cancer risk was not statistically significant (odds ratio [OR], 0.93; 95% confidence interval [CI], 0.68-1.29; P = 0.65; random model). Furthermore, subgroup analyses by cancer type also did not reveal an association between ACE polymorphisms and colorectal cancer (OR, 1.14; 95% CI, 0.823-1.58; P = 0.43; random effect model) and gastric cancer (OR, 0.79; 95% CI, 0.51-1.22; P = 0.28; random effect model). These findings indicate that ACE polymorphisms in the digestive tract may still affect the survival of cancer patients, and future studies into the topic of effect of ACE on cancer prognosis are warranted.The angiotensin-converting enzyme (ACE) is the major regulator of the renin-angiotensin system, and it has been reported that genetic polymorphisms at this locus are associated with risk in numerous types of human cancers. In the current meta-analysis, we aimed to evaluate the association between the ACE Gene insertion/deletion (I/D) polymorphism (DD vs II) and digestive system cancer susceptibility. A total of 19 case-control studies among 3722 patients with seven different types of cancer were included in this meta-analysis. In the pooled analysis, the relationship between the ACE I/D polymorphism and digestive system cancer risk was not statistically significant (odds ratio [OR], 0.93; 95% confidence interval [CI], 0.68-1.29; P = 0.65; random model). Furthermore, subgroup analyses by cancer type also did not reveal an association between ACE polymorphisms and colorectal cancer (OR, 1.14; 95% CI, 0.823-1.58; P = 0.43; random effect model) and gastric cancer (OR, 0.79; 95% CI, 0.51-1.22; P = 0.28; random effect model). These findings indicate that ACE polymorphisms in the digestive tract may still affect the survival of cancer patients, and future studies into the topic of effect of ACE on cancer prognosis are warranted.
The angiotensin‐converting enzyme (ACE) is the major regulator of the renin‐angiotensin system, and it has been reported that genetic polymorphisms at this locus are associated with risk in numerous types of human cancers. In the current meta‐analysis, we aimed to evaluate the association between the ACE Gene insertion/deletion (I/D) polymorphism ( DD vs II ) and digestive system cancer susceptibility. A total of 19 case‐control studies among 3722 patients with seven different types of cancer were included in this meta‐analysis. In the pooled analysis, the relationship between the ACE I/D polymorphism and digestive system cancer risk was not statistically significant (odds ratio [OR], 0.93; 95% confidence interval [CI], 0.68‐1.29; P  = 0.65; random model). Furthermore, subgroup analyses by cancer type also did not reveal an association between ACE polymorphisms and colorectal cancer (OR, 1.14; 95% CI, 0.823‐1.58; P  = 0.43; random effect model) and gastric cancer (OR, 0.79; 95% CI, 0.51‐1.22; P  = 0.28; random effect model). These findings indicate that ACE polymorphisms in the digestive tract may still affect the survival of cancer patients, and future studies into the topic of effect of ACE on cancer prognosis are warranted.
The angiotensin‐converting enzyme (ACE) is the major regulator of the renin‐angiotensin system, and it has been reported that genetic polymorphisms at this locus are associated with risk in numerous types of human cancers. In the current meta‐analysis, we aimed to evaluate the association between the ACE Gene insertion/deletion (I/D) polymorphism (DD vs II) and digestive system cancer susceptibility. A total of 19 case‐control studies among 3722 patients with seven different types of cancer were included in this meta‐analysis. In the pooled analysis, the relationship between the ACE I/D polymorphism and digestive system cancer risk was not statistically significant (odds ratio [OR], 0.93; 95% confidence interval [CI], 0.68‐1.29; P = 0.65; random model). Furthermore, subgroup analyses by cancer type also did not reveal an association between ACE polymorphisms and colorectal cancer (OR, 1.14; 95% CI, 0.823‐1.58; P = 0.43; random effect model) and gastric cancer (OR, 0.79; 95% CI, 0.51‐1.22; P = 0.28; random effect model). These findings indicate that ACE polymorphisms in the digestive tract may still affect the survival of cancer patients, and future studies into the topic of effect of ACE on cancer prognosis are warranted. In the current meta‐analysis, we aimed to evaluate the association between the ACE Gene insertion/deletion (I/D) polymorphism (DD vs II) and digestive system cancer susceptibility. A total of 19 case‐control studies among 3722 patients with seven different types of cancer were included in this meta‐analysis. Our findings indicate that ACE polymorphisms in the digestive tract may still affect the survival of cancer patients, and future studies into the topic of effect of ACE on cancer prognosis are warranted.
Author Khazaei, Majid
Abdeahad, Hossein
Ryzhikov, Mikhail
Soleimanpour, Saman
Bahrami, Afsane
Avan, Amir
Ferns, Gordon A.
Fiuji, Hamid
Hassanian, Seyed Mahdi
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  surname: Hassanian
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Keywords colorectal cancer
gastric cancer
Renin-angiotensin system
angiotensin-converting enzyme
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Snippet The angiotensin‐converting enzyme (ACE) is the major regulator of the renin‐angiotensin system, and it has been reported that genetic polymorphisms at this...
The angiotensin-converting enzyme (ACE) is the major regulator of the renin-angiotensin system, and it has been reported that genetic polymorphisms at this...
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wiley
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StartPage 19388
SubjectTerms ACE protein
Angiotensin
angiotensin‐converting enzyme
Cancer
Colorectal cancer
Colorectal carcinoma
Confidence intervals
Conversion
Digestive system
Enzymes
Gastric cancer
Gastrointestinal tract
Gene deletion
Gene polymorphism
Health risks
Insertion
Medical prognosis
Meta-analysis
Polymorphism
Renin
Renin‐angiotensin system
Risk analysis
Statistical analysis
Subgroups
Title Angiotensin‐converting enzyme gene polymorphism and digestive system cancer risk: A meta‐analysis based on 9656 subjects
URI https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fjcb.28955
https://www.ncbi.nlm.nih.gov/pubmed/31478246
https://www.proquest.com/docview/2304880230
https://www.proquest.com/docview/2283987812
Volume 120
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