Erythrocyte membrane fluidity as a marker of diabetic retinopathy in type 1 diabetes mellitus

• Published in: European journal of clinical investigation Vol. 51; no. 5; pp. e13455 - n/a
• Main Authors: Bianchetti, Giada, Viti, Luca, Scupola, Andrea, Di Leo, Mauro, Tartaglione, Linda, Flex, Andrea, De Spirito, Marco, Pitocco, Dario, Maulucci, Giuseppe
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.05.2021
• Subjects: Body mass; Body mass index; Body size; Complications; Creatinine; Diabetes; Diabetes mellitus; Diabetes mellitus (insulin dependent); Diabetic retinopathy; Erythrocytes; Fluidity; Fluorescence; generalized polarization; Glycosylation; Hemoglobin; Hyperglycemia; Laurdan; Lipid peroxidation; Lipids; Markers; Membrane fluidity; Membranes; metabolic imaging; Peroxidation; Reactive oxygen species; Retinopathy; Risk analysis; Risk factors; Statistical analysis; Variance analysis; Viscosity; Laurdan; diabetes mellitus; generalized polarization; diabetic retinopathy; metabolic imaging; membrane fluidity

Background A high level of glycosylated haemoglobin (HbA1c), which is a nonenzymatic glycosylation product, is correlated with an increased risk of developing microangiopathic complications in Diabetes Mellitus (DM). Erythrocyte membrane fluidity could provide a complementary index to monitor the de...