Hsa_circ_0005519 increases IL‐13/IL‐6 by regulating hsa‐let‐7a‐5p in CD4+ T cells to affect asthma

• Published in: Clinical and experimental allergy Vol. 49; no. 8; pp. 1116 - 1127
• Main Authors: Huang, Zhenli, Cao, Yong, Zhou, Min, Qi, Xuefei, Fu, Bohua, Mou, Yong, Wu, Guorao, Xie, Jungang, Zhao, Jianping, Xiong, Weining
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.08.2019
• Subjects: Asthma; Biomarkers; CD4 antigen; CD4+ T cells; hsa_circ_0005519; hsa‐let‐7a‐5p; Inflammation; Leukocytes (eosinophilic); Lymphocytes; Lymphocytes T; mRNA; Nitric oxide; Patients; PBMCs; Peripheral blood; asthma; CD4+ T cells; hsa-let-7a-5p; PBMCs; hsa_circ_0005519

Background Circular RNAs (circRNAs) are a class of non‐coding RNAs that could serve as novel biomarkers for the diagnosis and treatment of diseases. We hypothesized that circRNAs of CD4+ T cells are involved in asthma. Objective In this study, we investigated the circRNA expression profile and the p...