Mast cell infiltration associated with loss of interstitial cells of Cajal and neuronal degeneration in achalasia

• Published in: Neurogastroenterology and motility Vol. 31; no. 5; pp. e13565 - n/a
• Main Authors: Liu, Zu‐Qiang, Chen, Wei‐Feng, Wang, Yun, Xu, Xiao‐Yue, Zeng, Yi‐Gang, Lee Dillon, Dustin, Cheng, Jing, Xu, Mei‐Dong, Zhong, Yun‐Shi, Zhang, Yi‐Qun, Yao, Li‐Qing, Zhou, Ping‐Hong, Li, Quan‐Lin
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.05.2019
• Subjects: Achalasia; Adolescent; Adult; Aged; Autoimmune diseases; Biopsy; Child; Degeneration; Esophageal Achalasia - pathology; Esophageal sphincter; Esophageal Sphincter, Lower - pathology; Esophagus; Etiology; Female; Histamine; Humans; Immunohistochemistry; Inflammation; Interstitial cells; Interstitial cells of Cajal; Interstitial Cells of Cajal - pathology; Male; Mast cells; Mast Cells - pathology; Middle Aged; Nerve Degeneration - pathology; neuronal degeneration; Sphincter; Young Adult; neuronal degeneration; achalasia; mast cells; interstitial cells of Cajal

Background Achalasia is a motility disorder of unknown etiology. Previous studies supported the hypothesis that autoimmune‐mediated inflammatory responses produce inhibitory neuronal degeneration. This study was designed to explore the role of mast cells in achalasia. Methods We collected informatio...