Tryptophan–kynurenine ratio as a biomarker of bladder cancer

• Published in: BJU international Vol. 127; no. 4; pp. 445 - 453
• Main Authors: Lee, Sze Han, Mahendran, Ratha, Tham, Sin Mun, Thamboo, Thomas Paulraj, Chionh, Billy Jianhao, Lim, Yi Xin, Tsang, Woon Chau, Wu, Qing Hui, Chia, Jun Yang, Tay, Melissa Hui Wen, Goh, Benjamin Yen Seow, Chen, Kelven Weijing, Mallari, Jeane Zepeda, Periaswami, Revathi, Raman, Lata, Choo, Shoa Nian, Kioh, Dorinda Yan Qin, Chiong, Edmund, Esuvaranathan, Kesavan, Chan, Eric Chun Yong
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.04.2021
• Subjects: Animal models; biomarker; Biomarkers; Bladder cancer; BladderCancer; blcsm; Cancer; Creatinine; Dioxygenase; kynurenine; Prostate; surveillance; Tryptophan; Tumors; uroonc; utuc; uroonc; blcsm; bladder cancer; kynurenine; utuc; surveillance; BladderCancer; biomarker; tryptophan

Objectives To investigate plasma and urinary kynurenine (KYN)–tryptophan (TRP) ratios in bladder cancer, expression of indoleamine 2,3‐dioxygenase 1 (IDO1) in relation to tryptophan 2,3‐dioxygenase (TDO2) in bladder tumour, and the correlation of KYN–TRP ratio with bladder tumour burden. Methods Met...