Development and validation of a novel epigenetic signature for predicting prognosis in colon cancer

• Published in: Journal of cellular physiology Vol. 235; no. 11; pp. 8714 - 8723
• Main Authors: Luo, Dakui, Liu, Qi, Shan, Zezhi, Cai, Sanjun, Li, Qingguo, Li, Xinxiang
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.11.2020
• Subjects: Biomarkers; Biomarkers, Tumor - genetics; Carcinogenesis; Carcinogens; Chemotherapy; Chromatin; Colon; Colon cancer; Colonic Neoplasms - diagnosis; Colonic Neoplasms - genetics; Colonic Neoplasms - pathology; Colorectal cancer; DNA microarrays; epigenetic regulation; Epigenetics; Epigenomics - methods; Gene expression; Gene Expression Profiling - methods; Gene Expression Regulation, Neoplastic; gene signature; GEO database; Humans; Medical prognosis; Neoplasm Recurrence, Local - diagnosis; Neoplasm Recurrence, Local - genetics; Nomograms; Prognosis; relapse‐free survival; Reproducibility of Results; Risk; Risk groups; ROC Curve; Time dependence; Training; relapse-free survival; GEO database; gene signature; epigenetic regulation; colon cancer

Epigenetic factors play a critical role in carcinogenesis by imparting a distinct feature to the chromatin architecture. The present study aimed to develop a novel epigenetic signature for evaluating the relapse‐free survival of colon cancer patients. Public microarray datasets were acquired from th...