Associations of circulating metabolites with cerebral white matter hyperintensities

• Published in: Journal of neurochemistry Vol. 166; no. 2; pp. 414 - 423
• Main Authors: Sun, Yan, Guo, Yu, Li, Hong‐Qi, Tan, Lan, Feng, Jian‐Feng, Cheng, Wei, Yu, Jin‐Tai
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.07.2023
• Subjects: Adult; brain health; Dementia disorders; Fatty acids; Glycoproteins; Health risks; High density lipoprotein; Humans; lipidomics; Magnetic Resonance Imaging; Male; Metabolites; Metabolomics; Middle Aged; Regression analysis; Regression models; Risk Factors; Sex; small vessel diseases; Stroke - complications; Substantia alba; White Matter; white matter hyperintensity; metabolomics; small vessel diseases; brain health; lipidomics; white matter hyperintensity

White matter hyperintensities (WMH) are the most compelling risk factors of stroke, dementia, and early mortality. We aimed to investigate the associations between WMH and circulating metabolites. We studied up to 8190 individuals from the UK Biobank, who have both measurements of 249 plasma metabol...