An imaging mass spectrometry atlas of lipids in the human neurologically normal and Huntington’s disease caudate nucleus

• Published in: Journal of neurochemistry Vol. 157; no. 6; pp. 2158 - 2172
• Main Authors: Hunter, Mandana, Demarais, Nicholas J., Faull, Richard L. M., Grey, Angus C., Curtis, Maurice A.
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.06.2021
• Subjects: Abundance; Caudate nucleus; Cyclotron resonance; Fourier transforms; Ganglioside GM1; Huntington's disease; Huntingtons disease; imaging mass spectrometry; Ions; lipid; lipidomics; Lipids; Liquid chromatography; MALDI; Mass spectrometry; Mass spectroscopy; Medical imaging; Molecular modelling; Neostriatum; Neurodegeneration; Neuroimaging; Neuroprotection; Perturbation; Scientific imaging; Spectroscopy; Substantia alba; caudate nucleus; imaging mass spectrometry; Huntington's disease; lipid; MALDI; lipidomics
• ISSN: 0022-3042; 1471-4159; 1471-4159
• DOI: 10.1111/jnc.15325

Huntington's disease (HD) is a fatal disorder associated with germline trinucleotide repeat expansions in the HTT gene and characterised by striatal neurodegeneration. No efficacious interventions are available for HD, highlighting a major unmet medical need. The molecular mechanisms underlying...