Genetic profiles of transcriptomic clusters of childhood asthma determine specific severe subtype

• Published in: Clinical and experimental allergy Vol. 48; no. 9; pp. 1164 - 1172
• Main Authors: Yeh, Y.‐L., Su, M.‐W., Chiang, B.‐L., Yang, Y.‐H., Tsai, C.‐H., Lee, Y. L.
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.09.2018
• Subjects: Asthma; CD8 antigen; CD8+ T cells; Children; DNA microarrays; Eosinophils; Epithelium; Gene expression; gene expression profiling; Glucocorticoids; Helper cells; Inflammation; Leukocytes (eosinophilic); Leukocytes (mononuclear); Leukocytes (neutrophilic); Lymphocytes; Lymphocytes T; molecular phenotyping; Patients; PBMC; Peripheral blood mononuclear cells; Signal transduction; Sputum; TH1/TH17 severe asthma; CD8+ T cells; molecular phenotyping; gene expression profiling; PBMC; TH1/TH17 severe asthma

Summary Background Previous studies have defined transcriptomic subtypes of adult asthma using samples of induced sputum and bronchial epithelium; however, those procedures are not readily applicable in the clinic, especially for childhood asthma. Objective We aim to dissect the transcriptomic clust...