Further analysis of acute antinociceptive and anti‐inflammatory actions of 4‐phenylselenyl‐7‐chloroquinoline in mice

A new quinoline containing selenium, 4‐phenylselenyl‐7‐chloroquinoline (4‐PSQ), was described and synthetized by our research group. Recently, we demonstrated the potential antinociceptive and anti‐inflammatory of 4‐PSQ. For this reason, the first objective of this study was to expand our previous f...

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Published inFundamental & clinical pharmacology Vol. 31; no. 5; pp. 513 - 525
Main Authors Silva, Vanessa D. G., Reis, Angélica S., Pinz, Mikaela P., Fonseca, Caren A. R., Duarte, Luis Fernando B., Roehrs, Juliano A., Alves, Diego, Luchese, Cristiane, Wilhelm, Ethel A.
Format Journal Article
LanguageEnglish
Published England Wiley Subscription Services, Inc 01.10.2017
Subjects
Acetic acid
Analgesics - chemistry
Analgesics - pharmacology
Analgesics - therapeutic use
Animals
Anti-Inflammatory Agents - chemistry
Anti-Inflammatory Agents - pharmacology
Anti-Inflammatory Agents - therapeutic use
Arginine
Carrageenan
Carrageenan - toxicity
Dizocilpine
Exudation
glutamate
Glutamatergic transmission
Glutamic acid receptors (ionotropic)
Inflammation
Ketanserin
Male
Mice
N-Methyl-D-aspartic acid receptors
Nitric oxide
nociception
Organoselenium Compounds - chemistry
Organoselenium Compounds - pharmacology
Organoselenium Compounds - therapeutic use
Pain Measurement - drug effects
Pain Measurement - methods
Pain perception
Peroxidase
Pharmacology
Pindolol
Pleurisy
Pleurisy - chemically induced
Pleurisy - drug therapy
Pleurisy - pathology
Pretreatment
Quinoline
Quinolines - chemistry
Quinolines - pharmacology
Quinolines - therapeutic use
Receptors
Selenium
serotonin
Serotonin S1 receptors
Serotonin S2 receptors
Studies
nociception
nitric oxide
serotonin
selenium
inflammation
glutamate
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Abstract A new quinoline containing selenium, 4‐phenylselenyl‐7‐chloroquinoline (4‐PSQ), was described and synthetized by our research group. Recently, we demonstrated the potential antinociceptive and anti‐inflammatory of 4‐PSQ. For this reason, the first objective of this study was to expand our previous findings by investigating the contribution of glutamatergic, serotonergic, and nitrergic systems to the acute antinociceptive action of this compound. Pretreatment with 4‐PSQ (0.01–25 mg/kg, p.o.) reduced the nociception induced by glutamate. MK‐801 (an uncompetitive antagonist of the N‐Methyl‐d‐aspartate (NMDA) receptor) blocked the antinociceptive effect exerted by 4‐PSQ (25 mg/kg, p.o.) in the acetic acid‐induced abdominal writhing test. The pretreatment with WAY100635 (a selective antagonist of 5‐HT1A receptor), ketanserin (a selective antagonist of 5‐HT2A/2C receptor), and pindolol (a nonselective antagonist of 5‐HT1A/1B receptors) partially blocked the antinociceptive effect caused by 4‐PSQ (25 mg/kg, per oral, p.o.) in the acetic acid‐induced abdominal writhing test. Nitric oxide precursor, l‐arginine hydrochloride, partially reversed antinociception caused by 4‐PSQ or ω‐nitro‐l‐arginine (l‐NOARG). Treatments did not modify the locomotor and exploratory activities of mice. Additionally, the acute anti‐inflammatory effect of 4‐PSQ in a model of pleurisy induced by carrageenan in mice was investigated. 4‐PSQ reduced the cellular migration, pleural exudate accumulation, and myeloperoxidase activity induced by carrageenan exposure. 4‐PSQ protected against the increase in reactive species levels and reduction of nonprotein thiol levels induced by carrageenan. Data presented here showed that the modulation of serotonergic, nitrergic, and glutamatergic systems contributed to the antinociceptive effect of 4‐PSQ and it reinforced the therapeutic potential of this quinolinic compound for acute inflammation.
AbstractList A new quinoline containing selenium, 4-phenylselenyl-7-chloroquinoline (4-PSQ), was described and synthetized by our research group. Recently, we demonstrated the potential antinociceptive and anti-inflammatory of 4-PSQ. For this reason, the first objective of this study was to expand our previous findings by investigating the contribution of glutamatergic, serotonergic, and nitrergic systems to the acute antinociceptive action of this compound. Pretreatment with 4-PSQ (0.01-25 mg/kg, p.o.) reduced the nociception induced by glutamate. MK-801 (an uncompetitive antagonist of the N-Methyl-d-aspartate (NMDA) receptor) blocked the antinociceptive effect exerted by 4-PSQ (25 mg/kg, p.o.) in the acetic acid-induced abdominal writhing test. The pretreatment with WAY100635 (a selective antagonist of 5-HT1A receptor), ketanserin (a selective antagonist of 5-HT2A/2C receptor), and pindolol (a nonselective antagonist of 5-HT1A/1B receptors) partially blocked the antinociceptive effect caused by 4-PSQ (25 mg/kg, per oral, p.o.) in the acetic acid-induced abdominal writhing test. Nitric oxide precursor, l-arginine hydrochloride, partially reversed antinociception caused by 4-PSQ or [omega]-nitro-l-arginine (l-NOARG). Treatments did not modify the locomotor and exploratory activities of mice. Additionally, the acute anti-inflammatory effect of 4-PSQ in a model of pleurisy induced by carrageenan in mice was investigated. 4-PSQ reduced the cellular migration, pleural exudate accumulation, and myeloperoxidase activity induced by carrageenan exposure. 4-PSQ protected against the increase in reactive species levels and reduction of nonprotein thiol levels induced by carrageenan. Data presented here showed that the modulation of serotonergic, nitrergic, and glutamatergic systems contributed to the antinociceptive effect of 4-PSQ and it reinforced the therapeutic potential of this quinolinic compound for acute inflammation.
A new quinoline containing selenium, 4‐phenylselenyl‐7‐chloroquinoline (4‐PSQ), was described and synthetized by our research group. Recently, we demonstrated the potential antinociceptive and anti‐inflammatory of 4‐PSQ. For this reason, the first objective of this study was to expand our previous findings by investigating the contribution of glutamatergic, serotonergic, and nitrergic systems to the acute antinociceptive action of this compound. Pretreatment with 4‐PSQ (0.01–25 mg/kg, p.o.) reduced the nociception induced by glutamate. MK‐801 (an uncompetitive antagonist of the N‐Methyl‐d‐aspartate (NMDA) receptor) blocked the antinociceptive effect exerted by 4‐PSQ (25 mg/kg, p.o.) in the acetic acid‐induced abdominal writhing test. The pretreatment with WAY100635 (a selective antagonist of 5‐HT1A receptor), ketanserin (a selective antagonist of 5‐HT2A/2C receptor), and pindolol (a nonselective antagonist of 5‐HT1A/1B receptors) partially blocked the antinociceptive effect caused by 4‐PSQ (25 mg/kg, per oral, p.o.) in the acetic acid‐induced abdominal writhing test. Nitric oxide precursor, l‐arginine hydrochloride, partially reversed antinociception caused by 4‐PSQ or ω‐nitro‐l‐arginine (l‐NOARG). Treatments did not modify the locomotor and exploratory activities of mice. Additionally, the acute anti‐inflammatory effect of 4‐PSQ in a model of pleurisy induced by carrageenan in mice was investigated. 4‐PSQ reduced the cellular migration, pleural exudate accumulation, and myeloperoxidase activity induced by carrageenan exposure. 4‐PSQ protected against the increase in reactive species levels and reduction of nonprotein thiol levels induced by carrageenan. Data presented here showed that the modulation of serotonergic, nitrergic, and glutamatergic systems contributed to the antinociceptive effect of 4‐PSQ and it reinforced the therapeutic potential of this quinolinic compound for acute inflammation.
Abstract A new quinoline containing selenium, 4‐phenylselenyl‐7‐chloroquinoline (4‐ PSQ ), was described and synthetized by our research group. Recently, we demonstrated the potential antinociceptive and anti‐inflammatory of 4‐ PSQ . For this reason, the first objective of this study was to expand our previous findings by investigating the contribution of glutamatergic, serotonergic, and nitrergic systems to the acute antinociceptive action of this compound. Pretreatment with 4‐ PSQ (0.01–25 mg/kg, p.o.) reduced the nociception induced by glutamate. MK ‐801 (an uncompetitive antagonist of the N ‐Methyl‐ d ‐aspartate ( NMDA ) receptor) blocked the antinociceptive effect exerted by 4‐ PSQ (25 mg/kg, p.o.) in the acetic acid‐induced abdominal writhing test. The pretreatment with WAY 100635 (a selective antagonist of 5‐ HT 1A receptor), ketanserin (a selective antagonist of 5‐ HT 2A/2C receptor), and pindolol (a nonselective antagonist of 5‐ HT 1A/1B receptors) partially blocked the antinociceptive effect caused by 4‐ PSQ (25 mg/kg, per oral, p.o.) in the acetic acid‐induced abdominal writhing test. Nitric oxide precursor, l ‐arginine hydrochloride, partially reversed antinociception caused by 4‐ PSQ or ω‐nitro‐ l ‐arginine ( l ‐ NOARG ). Treatments did not modify the locomotor and exploratory activities of mice. Additionally, the acute anti‐inflammatory effect of 4‐ PSQ in a model of pleurisy induced by carrageenan in mice was investigated. 4‐ PSQ reduced the cellular migration, pleural exudate accumulation, and myeloperoxidase activity induced by carrageenan exposure. 4‐ PSQ protected against the increase in reactive species levels and reduction of nonprotein thiol levels induced by carrageenan. Data presented here showed that the modulation of serotonergic, nitrergic, and glutamatergic systems contributed to the antinociceptive effect of 4‐ PSQ and it reinforced the therapeutic potential of this quinolinic compound for acute inflammation.
A new quinoline containing selenium, 4-phenylselenyl-7-chloroquinoline (4-PSQ), was described and synthetized by our research group. Recently, we demonstrated the potential antinociceptive and anti-inflammatory of 4-PSQ. For this reason, the first objective of this study was to expand our previous findings by investigating the contribution of glutamatergic, serotonergic, and nitrergic systems to the acute antinociceptive action of this compound. Pretreatment with 4-PSQ (0.01-25 mg/kg, p.o.) reduced the nociception induced by glutamate. MK-801 (an uncompetitive antagonist of the N-Methyl-d-aspartate (NMDA) receptor) blocked the antinociceptive effect exerted by 4-PSQ (25 mg/kg, p.o.) in the acetic acid-induced abdominal writhing test. The pretreatment with WAY100635 (a selective antagonist of 5-HT receptor), ketanserin (a selective antagonist of 5-HT receptor), and pindolol (a nonselective antagonist of 5-HT receptors) partially blocked the antinociceptive effect caused by 4-PSQ (25 mg/kg, per oral, p.o.) in the acetic acid-induced abdominal writhing test. Nitric oxide precursor, l-arginine hydrochloride, partially reversed antinociception caused by 4-PSQ or ω-nitro-l-arginine (l-NOARG). Treatments did not modify the locomotor and exploratory activities of mice. Additionally, the acute anti-inflammatory effect of 4-PSQ in a model of pleurisy induced by carrageenan in mice was investigated. 4-PSQ reduced the cellular migration, pleural exudate accumulation, and myeloperoxidase activity induced by carrageenan exposure. 4-PSQ protected against the increase in reactive species levels and reduction of nonprotein thiol levels induced by carrageenan. Data presented here showed that the modulation of serotonergic, nitrergic, and glutamatergic systems contributed to the antinociceptive effect of 4-PSQ and it reinforced the therapeutic potential of this quinolinic compound for acute inflammation.
Author Pinz, Mikaela P.
Luchese, Cristiane
Reis, Angélica S.
Duarte, Luis Fernando B.
Fonseca, Caren A. R.
Roehrs, Juliano A.
Silva, Vanessa D. G.
Alves, Diego
Wilhelm, Ethel A.
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  givenname: Vanessa D. G.
  surname: Silva
  fullname: Silva, Vanessa D. G.
  organization: CCQFA ‐ Universidade Federal de Pelotas
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  givenname: Angélica S.
  surname: Reis
  fullname: Reis, Angélica S.
  organization: CCQFA ‐ Universidade Federal de Pelotas
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  givenname: Mikaela P.
  surname: Pinz
  fullname: Pinz, Mikaela P.
  organization: CCQFA ‐ Universidade Federal de Pelotas
– sequence: 4
  givenname: Caren A. R.
  surname: Fonseca
  fullname: Fonseca, Caren A. R.
  organization: CCQFA ‐ Universidade Federal de Pelotas
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  givenname: Luis Fernando B.
  surname: Duarte
  fullname: Duarte, Luis Fernando B.
  organization: Laboratório de Síntese Orgânica Limpa ‐ LASOL ‐ CCQFA ‐ Universidade Federal de Pelotas
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  givenname: Juliano A.
  surname: Roehrs
  fullname: Roehrs, Juliano A.
  organization: Laboratório de Síntese Orgânica Limpa ‐ LASOL ‐ CCQFA ‐ Universidade Federal de Pelotas
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  givenname: Diego
  surname: Alves
  fullname: Alves, Diego
  organization: Laboratório de Síntese Orgânica Limpa ‐ LASOL ‐ CCQFA ‐ Universidade Federal de Pelotas
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  givenname: Cristiane
  surname: Luchese
  fullname: Luchese, Cristiane
  email: cristiane_luchese@yahoo.com.br
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  givenname: Ethel A.
  orcidid: 0000-0002-2875-9962
  surname: Wilhelm
  fullname: Wilhelm, Ethel A.
  email: ethelwilhelm@yahoo.com.br
  organization: CCQFA ‐ Universidade Federal de Pelotas
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Issue 5
Keywords nociception
nitric oxide
serotonin
selenium
inflammation
glutamate
Language English
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PublicationTitle Fundamental & clinical pharmacology
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Snippet A new quinoline containing selenium, 4‐phenylselenyl‐7‐chloroquinoline (4‐PSQ), was described and synthetized by our research group. Recently, we demonstrated...
A new quinoline containing selenium, 4-phenylselenyl-7-chloroquinoline (4-PSQ), was described and synthetized by our research group. Recently, we demonstrated...
Abstract A new quinoline containing selenium, 4‐phenylselenyl‐7‐chloroquinoline (4‐ PSQ ), was described and synthetized by our research group. Recently, we...
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SubjectTerms Acetic acid
Analgesics - chemistry
Analgesics - pharmacology
Analgesics - therapeutic use
Animals
Anti-Inflammatory Agents - chemistry
Anti-Inflammatory Agents - pharmacology
Anti-Inflammatory Agents - therapeutic use
Arginine
Carrageenan
Carrageenan - toxicity
Dizocilpine
Exudation
glutamate
Glutamatergic transmission
Glutamic acid receptors (ionotropic)
Inflammation
Ketanserin
Male
Mice
N-Methyl-D-aspartic acid receptors
Nitric oxide
nociception
Organoselenium Compounds - chemistry
Organoselenium Compounds - pharmacology
Organoselenium Compounds - therapeutic use
Pain Measurement - drug effects
Pain Measurement - methods
Pain perception
Peroxidase
Pharmacology
Pindolol
Pleurisy
Pleurisy - chemically induced
Pleurisy - drug therapy
Pleurisy - pathology
Pretreatment
Quinoline
Quinolines - chemistry
Quinolines - pharmacology
Quinolines - therapeutic use
Receptors
Selenium
serotonin
Serotonin S1 receptors
Serotonin S2 receptors
Studies
Title Further analysis of acute antinociceptive and anti‐inflammatory actions of 4‐phenylselenyl‐7‐chloroquinoline in mice
URI https://onlinelibrary.wiley.com/doi/abs/10.1111%2Ffcp.12295
https://www.ncbi.nlm.nih.gov/pubmed/28543930
https://www.proquest.com/docview/1934925878
https://search.proquest.com/docview/1903164991
Volume 31
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