Oral Lactobacillus zeae exacerbates the pathological manifestation of periodontitis in a mouse model

• Published in: Molecular oral microbiology Vol. 39; no. 5; pp. 344 - 353
• Main Authors: Chen, Yi‐Wen, Hou, Yu‐Wen, Wang, Chuang‐Wei, Cheng, Shih‐Jung, Kuo, Wei‐Ting, Lin, Chun‐Pin, Hou, Hsin‐Han
• Format: Journal Article
• Language: English
• Published: Denmark Wiley Subscription Services, Inc 01.10.2024
• Subjects: Acid phosphatase; Acid phosphatase (tartrate-resistant); Acid resistance; Alveolar bone; Alveolar Bone Loss - microbiology; Alveolar Bone Loss - pathology; Animals; Bone loss; Cell activation; Competition; Computed tomography; Cytokines; Cytokines - metabolism; Dental plaque; Dental Plaque - microbiology; Disease Models, Animal; Dysbacteriosis; Dysbiosis - microbiology; Female; Gingival Crevicular Fluid - microbiology; Gum disease; Humans; Immune system; Immunohistochemistry; In vivo methods and tests; Infiltration; Inflammation; Lactobacillus; Lactobacillus zeae; Leukocytes (neutrophilic); ligature‐implanted mice; Male; Maxilla; metagenomic sequencing; Metagenomics; Mice; Mice, Inbred C57BL; Microorganisms; Patients; Periodontitis; Periodontitis - microbiology; Porphyromonas gingivalis; Porphyromonas gingivalis - pathogenicity; Probiotics; Probiotics - therapeutic use; Sequences; Staining; X-Ray Microtomography; Porphyromonas gingivalis; ligature‐implanted mice; metagenomic sequencing; Lactobacillus zeae; periodontitis

Introduction The worldwide prevalence of periodontitis is considerably high, and its pathogenic mechanisms must be investigated and understood in order to improve clinical treatment outcomes and reduce the disease prevalence and burden. The exacerbation of the host immune system induced by oral micr...