Central giant cell granulomas of the jaws stromal cells harbour mutations and have osteogenic differentiation capacity, in vivo and in vitro

• Published in: Journal of oral pathology & medicine Vol. 51; no. 2; pp. 206 - 216
• Main Authors: Miguita, Lucyene, de Souza, Juliana Cristina, Bastos, Victor Coutinho, Pereira, Nubia Braga, de Freitas, Raphaela Alvarenga Braga, Guimarães, Leticia Martins, de Avelar, Gleide Fernandes, Andrade, Luciana Oliveira, Dutra, Walderez Ornelas, Nunes, Fábio Daumas, Castro, Wagner Henriques, de Lacerda, Julio Cesar Tanos, Reis, Amanda Maria Sena, Bernardes, Vanessa Fátima, Diniz, Marina Gonçalves, Gomez, Ricardo Santiago, Gomes, Carolina Cavalieri
• Format: Journal Article
• Language: English
• Published: Denmark Wiley Subscription Services, Inc 01.02.2022
• Subjects: Alkaline Phosphatase; Bone cancer; Bone growth; bone tumour; Cbfa-1 protein; CD14 antigen; Cell culture; Cell Differentiation; Cells, Cultured; Cytochemistry; Fibroblast growth factor receptor 1; Flow cytometry; Gene expression; genetics; Giant cells; Granuloma, Giant Cell - genetics; Granulomas; Humans; Jaw; Lasers; Leukocytes (mononuclear); Macrophages; Mesenchymal Stem Cells; Mesenchyme; Monocytes; Mutation; mutations; Osteocalcin; Osteogenesis; Osteogenesis - genetics; Osteoid; Osteolysis; Osteopontin; patient‐derived xenograft; Stromal Cells; Tumors; Xenografts; genetics; mutations; osteogenesis; bone tumour; patient-derived xenograft

Background Central giant cell granulomas (CGCG) of the jaws are osteolytic lesions that may behave aggressively and respond poorly to surgery. Microscopically, in addition to giant cells, there is a mononuclear cell population composed of macrophage/monocytic cells and spindle‐shaped cells of mesenc...