CD83+ B cells alleviate uveitis through inhibiting DCs by sCD83

• Published in: Immunology Vol. 170; no. 1; pp. 134 - 153
• Main Authors: Feng, Meng, Wang, Xin, Zhou, Shuping, Li, Minghao, Liu, Tingting, Wei, Xunbin, Lin, Wei
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.09.2023
• Subjects: Autoimmune Diseases; autoimmune uveitis; B-Lymphocytes; Biological Transport; CD83 antigen; CD83+ B cells; DCs; Experimental autoimmune uveitis; Experimental autoimmune uveoretinitis; Eye; Humans; immunoregulation; Lymph nodes; Lymphocytes; Lymphocytes B; Lymphocytes T; Phosphorylation; Rab1a; sCD83; Signs and symptoms; Uveitis; immunoregulation; CD83+ B cells; Rab1a; autoimmune uveitis; sCD83; DCs
• ISSN: 0019-2805; 1365-2567; 1365-2567
• DOI: 10.1111/imm.13654

Soluble CD83 (sCD83) exerts immunosuppressive functions in many autoimmune diseases, including experimental autoimmune uveitis (EAU), but the cells and mechanisms involved are unclear. This study showed that CD83+ B cells were the main sources of sCD83. They alleviated the symptoms of EAU and decrea...