Long noncoding RNA LINC00473 drives the progression of pancreatic cancer via upregulating programmed death‐ligand 1 by sponging microRNA‐195‐5p

• Published in: Journal of cellular physiology Vol. 234; no. 12; pp. 23176 - 23189
• Main Authors: Zhou, Wen‐Yang, Zhang, Ming‐Ming, Liu, Chang, Kang, Ye, Wang, Jin‐Ou, Yang, Xiang‐Hong
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.12.2019
• Subjects: Apoptosis; BAX protein; Bcl-x protein; Beta cells; Cancer; CD8 antigen; CD8+ T cells; Cell migration; Cell proliferation; Cytoplasm; Interferon; Interleukins; Ligands; LINC00473; Lymphocytes; Lymphocytes T; Lymphoma; Matrix metalloproteinase; Matrix metalloproteinases; Metalloproteinase; MicroRNAs; microRNA‐195‐5p; miRNA; Pancreatic cancer; PD-L1 protein; Pheochromocytoma cells; programmed death‐ligand 1; Ribonucleic acid; RNA; siRNA; Survival; Tumorigenesis; CD8+ T cells; LINC00473; pancreatic cancer; programmed death-ligand 1; microRNA-195-5p

Pancreatic cancer (PC) is a great health burden to patients owing to its poor overall survival rate. Long noncoding RNAs (lncRNAs) interact with microRNAs (miRs) to participate in tumorigenesis. Therefore, we aim to uncover the role and related mechanism of LINC00473 in PC through the modulation of...