Kappa opioid receptor controls neural stem cell differentiation via a miR‐7a/Pax6 dependent pathway

• Published in: Stem cells (Dayton, Ohio) Vol. 39; no. 5; pp. 600 - 616
• Main Authors: Xu, Chi, Fan, Wenxiang, Zhang, Ying, Loh, Horace H., Law, Ping‐Yee
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.05.2021; Oxford University Press
• Subjects: 3' Untranslated regions; adult stem cells; Agonists; Beta2 protein; Cell differentiation; cell signaling; Differentiation (biology); Dynorphin A; Hippocampus; microRNA; miRNA; Narcotics; neural differentiation; Neural stem cells; Neurogenesis; Opioid receptors (type kappa); Pax6 protein; Receptors; signal transduction; Stem cell transplantation; Stem cells; Transcription; transcriptional regulation; neural stem cells; signal transduction; transcriptional regulation; cell signaling; microRNA; neural differentiation; adult stem cells

Although the roles of opioid receptors in neurogenesis have been implicated in previous studies, the mechanism by which κ‐opioid receptor (OPRK1) regulates adult neurogenesis remains elusive. We now demonstrate that two agonists of OPRK1, U50,488H and dynorphin A, inhibit adult neurogenesis by hinde...