circSKA3 acts as a sponge of miR‐6796‐5p to be associated with outcomes of ischemic stroke by regulating matrix metalloproteinase 9 expression

• Published in: European journal of neurology Vol. 29; no. 2; pp. 486 - 495
• Main Authors: Xu, Tian, Li, Yuqing, Zhu, Ning, Su, Yuanyuan, Li, Junrui, Ke, Kaifu
• Format: Journal Article
• Language: English
• Published: England John Wiley & Sons, Inc 01.02.2022
• Subjects: Biomarkers; circSKA3; competing endogenous RNA; Gelatinase B; Gene expression; Humans; Ischemia; ischemic stroke; Ischemic Stroke - genetics; Matrix metalloproteinase; Matrix Metalloproteinase 9 - genetics; Matrix metalloproteinases; Metalloproteinase; MicroRNAs; MicroRNAs - genetics; MicroRNAs - metabolism; miRNA; MMP9; Polymerase chain reaction; Ribonucleic acid; RNA; RNA, Circular - genetics; RNA, Messenger - genetics; Stroke; Therapeutic targets; Tubes; circSKA3; competing endogenous RNA; MMP9; ischemic stroke

Background and purpose This study was undertaken to screen the circular RNAs (circRNAs) influencing matrix metalloproteinase 9 (MMP9) through the competing endogenous RNA (ceRNA) network and evaluate the prognostic value of these circRNAs for acute ischemic stroke. Methods A total of 220 ischemic st...