Valproic Acid and Lithium Meditate Anti‐Inflammatory Effects by Differentially Modulating Dendritic Cell Differentiation and Function

• Published in: Journal of cellular physiology Vol. 232; no. 5; pp. 1176 - 1186
• Main Authors: Leu, Sy‐Jye, Yang, Yi‐Yuan, Liu, Hsing‐Cheng, Cheng, Chieh‐Yu, Wu, Yu‐Chen, Huang, Ming‐Chyi, Lee, Yuen‐Lun, Chen, Chi‐Ching, Shen, Winston W., Liu, Ko‐Jiunn
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.05.2017
• Subjects: Animals; Anti-Inflammatory Agents - pharmacology; Antigens, CD - metabolism; Arthritis, Experimental - drug therapy; Cattle; Cell differentiation; Cell Differentiation - drug effects; Cell Polarity - drug effects; Cytokines - metabolism; Dendritic Cells - cytology; Dendritic Cells - drug effects; Dendritic Cells - metabolism; Inflammation - pathology; Interleukin-10 - metabolism; Interleukin-6 - secretion; Interleukin-8 - metabolism; Lipid Metabolism - drug effects; Lipopolysaccharides; Lithium; Lithium Chloride - pharmacology; Lithium Chloride - therapeutic use; Mice; Monocytes - cytology; Th17 Cells - cytology; Th17 Cells - drug effects; Toll-Like Receptors - metabolism; Tumor Necrosis Factor-alpha - metabolism; Valproic Acid - pharmacology; Valproic Acid - therapeutic use

Valproic acid (VPA), with inhibition activity mainly toward histone deacetylase (HDAC) and Glycogen Synthase Kinase (GSK)‐3, and lithium, with inhibition activity mainly toward GSK‐3, are both prescribed in clinical as mood‐stabilizers and anticonvulsants for the control of bipolar disorder. This st...