HELLS Regulates Chromatin Remodeling and Epigenetic Silencing of Multiple Tumor Suppressor Genes in Human Hepatocellular Carcinoma

• Published in: Hepatology (Baltimore, Md.) Vol. 69; no. 5; pp. 2013 - 2030
• Main Authors: Law, Cheuk‐Ting, Wei, Lai, Tsang, Felice Ho‐Ching, Chan, Cerise Yuen‐Ki, Xu, Iris Ming‐Jing, Lai, Robin Kit‐Ho, Ho, Daniel Wai‐Hung, Lee, Joyce Man‐Fong, Wong, Carmen Chak‐Lui, Ng, Irene Oi‐Lin, Wong, Chun‐Ming
• Format: Journal Article
• Language: English
• Published: United States Wolters Kluwer Health, Inc 01.05.2019
• Subjects: Animals; Antigens, CD - metabolism; Cadherins - metabolism; Carcinogenesis; Carcinoma, Hepatocellular - enzymology; Carcinoma, Hepatocellular - etiology; Cell Line, Tumor; Cell migration; Cell proliferation; Chromatin Assembly and Disassembly; Chromatin remodeling; CRISPR; DNA helicase; DNA Helicases - genetics; DNA Helicases - metabolism; DNA methylation; Enhancers; Epigenesis, Genetic; Epigenetics; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; Genome editing; Genomes; Hepatocellular carcinoma; Hepatology; Humans; Insulin-like growth factor-binding protein 3; Liver cancer; Liver Neoplasms, Experimental - enzymology; Liver Neoplasms, Experimental - etiology; Metastases; Mice, Knockout; Mice, Nude; Neoplasm Metastasis; Nuclease; Nucleosomes - metabolism; Ribonucleic acid; RNA; Sp1 protein; Sp1 Transcription Factor - metabolism; Tumor suppressor genes

Hepatocellular carcinoma (HCC) is the third most lethal cancer worldwide. Increasing evidence shows that epigenetic alterations play an important role in human carcinogenesis. Deregulation of DNA methylation and histone modifications have recently been characterized in HCC, but the significance of c...