Differential deletion of GDNF in the auditory system leads to altered sound responsiveness

• Published in: Journal of neuroscience research Vol. 98; no. 9; pp. 1764 - 1779
• Main Authors: Harasztosi, Csaba, Wolter, Steffen, Gutsche, Katja, Durán‐Alonso, María Beatriz, López‐Hernández, Iris, Pascual, Alberto, López‐Barneo, José, Knipper, Marlies, Rüttiger, Lukas, Schimmang, Thomas
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.09.2020
• Subjects: Animal models; Auditory defects; Auditory system; Brain stem; Cochlea; Deactivation; Deafness; Foxg1 protein; Glial cell line-derived neurotrophic factor; glial‐derived neurotrophic factor; Hair; Hair cells; Hearing loss; Inactivation; inner ear; Lethality; Math1 protein; mouse; Mutants; Neurodegenerative diseases; Neuronal-glial interactions; Neurons; organ of Corti; Outer hair cells; RRID:AB_10000321; RRID:AB_2195374; RRID:AB_2286684; RRID:AB_2314839; RRID:AB_291611; RRID:AB_477272; RRID:AB_477329; RRID:AB_90760; Sensory neurons; Thresholds; Trauma; Wave analysis; cochlea; RRID:AB_2314839; glial-derived neurotrophic factor; RRID:AB_90760; RRID:AB_2195374; RRID:AB_477329; RRID:AB_477272; mouse; RRID:AB_291611; RRID:AB_2286684; RRID:AB_10000321; inner ear; organ of Corti

Glial‐derived neurotrophic factor (GDNF) has been proposed as a potent neurotrophic factor with the potential to cure neurodegenerative diseases. In the cochlea, GDNF has been detected in auditory neurons and sensory receptor cells and its expression is upregulated upon trauma. Moreover, the applica...