Hereditary breast cancer; Genetic penetrance and current status with BRCA

• Published in: Journal of cellular physiology Vol. 234; no. 5; pp. 5741 - 5750
• Main Authors: Mahdavi, Morteza, Nassiri, Mohammadreza, Kooshyar, Mohammad Mahdi, Vakili‐Azghandi, Masoume, Avan, Amir, Sandry, Ryan, Pillai, Suja, Lam, Alfred King‐yin, Gopalan, Vinod
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.05.2019
• Subjects: Animals; Biomarkers, Tumor - genetics; BRCA; BRCA1 protein; BRCA1 Protein - genetics; BRCA2 protein; BRCA2 Protein - genetics; Breast cancer; Breast Neoplasms - genetics; Cancer; Deoxyribonucleic acid; DNA; DNA repair; Environmental factors; Female; Genes; Genetic Predisposition to Disease; Genetic transformation; Genetics; Genomic instability; germline mutations; Health risk assessment; Health risks; hereditary genes; Heredity; Heterozygosity; Homology; Humans; Loss of Heterozygosity; Mutation; Ovarian cancer; p53 Protein; Patients; Pedigree; Penetrance; PTEN protein; Risk Assessment; Risk Factors; Stability; BRCA; breast cancer; germline mutations; hereditary genes

The most important cause of developing hereditary breast cancer is germline mutations occurring in breast cancer (BCs) susceptibility genes, for example, BRCA1, BRCA2, TP53, CHEK2, PTEN, ATM, and PPM1D. Many BC susceptibility genes can be grouped into two classes, high‐ and low‐penetrance genes, eac...