NK Cell‐Based Cancer Immunotherapies: Current Progress, Challenges and Emerging Opportunities

• Published in: Journal of biochemical and molecular toxicology Vol. 38; no. 11; pp. e70044 - n/a
• Main Authors: Alshahrani, Mohammad Y., Uthirapathy, Subasini, Kumar, Abhinav, Oghenemaro, Enwa Felix, R., Roopashree, Lal, Madan, Arora, Isha, Chauhan, Ashish Singh, Saud, Mahmood Jumaa, Hulail, Hanen Mahmod
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.11.2024
• Subjects: adoptive cell transplantation; Allografts; Animals; Anticancer properties; Antitumor activity; Cancer; Cancer immunotherapy; Cancer therapies; CAR NK cell; Cell therapy; combination therapy; drug resistance; Exosomes; Exosomes - immunology; Exosomes - transplantation; Humans; Immune system; Immunology; Immunosuppressive agents; Immunotherapy; Immunotherapy - methods; Killer Cells, Natural - immunology; Monoclonal antibodies; Natural killer cells; Neoplasms - immunology; Neoplasms - therapy; Side effects; Therapy; Tumor microenvironment; Tumor Microenvironment - immunology; Tumors; combination therapy; drug resistance; tumor microenvironment; adoptive cell transplantation; CAR NK cell; exosomes

ABSTRACT Natural killer (NK) cells are vital innate immune cells that play a crucial role in cancer therapy. They are targeted by therapies designed to modulate, retain, and enhance their antitumor function in vivo. In addition to whole‐cell therapy, NK cell‐derived exosomes (NDEs) offer high immune...