Effect of low vs high haemoglobin transfusion trigger on cardiac output in patients undergoing elective vascular surgery: Post‐hoc analysis of a randomized trial
Background During vascular surgery, restricted red‐cell transfusion reduces frontal lobe oxygen (ScO2) saturation as determined by near‐infrared spectroscopy. We evaluated whether inadequate increase in cardiac output (CO) following haemodilution explains reduction in ScO2. Methods This is a post‐ho...
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Published in | Acta anaesthesiologica Scandinavica Vol. 65; no. 3; pp. 302 - 312 |
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Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
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01.03.2021
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Abstract | Background
During vascular surgery, restricted red‐cell transfusion reduces frontal lobe oxygen (ScO2) saturation as determined by near‐infrared spectroscopy. We evaluated whether inadequate increase in cardiac output (CO) following haemodilution explains reduction in ScO2.
Methods
This is a post‐hoc analysis of data from the Transfusion in Vascular surgery (TV) Trial where patients were randomized on haemoglobin drop below 9.7 g/dL to red‐cell transfusion at haemoglobin below 8.0 (low‐trigger) vs 9.7 g/dL (high‐trigger). Fluid administration was guided by optimizing stroke volume. We compared mean intraoperative levels of CO, haemoglobin, oxygen delivery, and CO at nadir ScO2 with linear regression adjusted for age, operation type and baseline. Data for 46 patients randomized before end of surgery were included for analysis.
Results
The low‐trigger resulted in a 7.1% lower mean intraoperative haemoglobin level (mean difference, −0.74 g/dL; P < .001) and reduced volume of red‐cell transfused (median [inter‐quartile range], 0 [0‐300] vs 450 mL [300‐675]; P < .001) compared with the high‐trigger group. Mean CO during surgery was numerically 7.3% higher in the low‐trigger compared with the high‐trigger group (mean difference, 0.36 L/min; 95% confidence interval (CI.95), −0.05 to 0.78; P = .092; n = 42). At the nadir ScO2‐level, CO was 11.9% higher in the low‐trigger group (mean difference, 0.58 L/min; CI.95, 0.10‐1.07; P = .024). No difference in oxygen delivery was detected between trial groups (MD, 1.39 dLO2/min; CI.95, −6.16 to 8.93; P = .721).
Conclusion
Vascular surgical patients exposed to restrictive RBC transfusion elicit the expected increase in CO making it unlikely that their potentially limited cardiac capacity explains the associated ScO2 decrease. |
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AbstractList | During vascular surgery, restricted red-cell transfusion reduces frontal lobe oxygen (ScO
) saturation as determined by near-infrared spectroscopy. We evaluated whether inadequate increase in cardiac output (CO) following haemodilution explains reduction in ScO
.
This is a post-hoc analysis of data from the Transfusion in Vascular surgery (TV) Trial where patients were randomized on haemoglobin drop below 9.7 g/dL to red-cell transfusion at haemoglobin below 8.0 (low-trigger) vs 9.7 g/dL (high-trigger). Fluid administration was guided by optimizing stroke volume. We compared mean intraoperative levels of CO, haemoglobin, oxygen delivery, and CO at nadir ScO
with linear regression adjusted for age, operation type and baseline. Data for 46 patients randomized before end of surgery were included for analysis.
The low-trigger resulted in a 7.1% lower mean intraoperative haemoglobin level (mean difference, -0.74 g/dL; P < .001) and reduced volume of red-cell transfused (median [inter-quartile range], 0 [0-300] vs 450 mL [300-675]; P < .001) compared with the high-trigger group. Mean CO during surgery was numerically 7.3% higher in the low-trigger compared with the high-trigger group (mean difference, 0.36 L/min; 95% confidence interval (CI.95), -0.05 to 0.78; P = .092; n = 42). At the nadir ScO
-level, CO was 11.9% higher in the low-trigger group (mean difference, 0.58 L/min; CI.95, 0.10-1.07; P = .024). No difference in oxygen delivery was detected between trial groups (MD, 1.39 dL
/min; CI.95, -6.16 to 8.93; P = .721).
Vascular surgical patients exposed to restrictive RBC transfusion elicit the expected increase in CO making it unlikely that their potentially limited cardiac capacity explains the associated ScO
decrease. Abstract Background During vascular surgery, restricted red‐cell transfusion reduces frontal lobe oxygen (ScO 2 ) saturation as determined by near‐infrared spectroscopy. We evaluated whether inadequate increase in cardiac output (CO) following haemodilution explains reduction in ScO 2 . Methods This is a post‐hoc analysis of data from the Transfusion in Vascular surgery (TV) Trial where patients were randomized on haemoglobin drop below 9.7 g/dL to red‐cell transfusion at haemoglobin below 8.0 (low‐trigger) vs 9.7 g/dL (high‐trigger). Fluid administration was guided by optimizing stroke volume. We compared mean intraoperative levels of CO, haemoglobin, oxygen delivery, and CO at nadir ScO 2 with linear regression adjusted for age, operation type and baseline. Data for 46 patients randomized before end of surgery were included for analysis. Results The low‐trigger resulted in a 7.1% lower mean intraoperative haemoglobin level (mean difference, −0.74 g/dL; P < .001) and reduced volume of red‐cell transfused (median [inter‐quartile range], 0 [0‐300] vs 450 mL [300‐675]; P < .001) compared with the high‐trigger group. Mean CO during surgery was numerically 7.3% higher in the low‐trigger compared with the high‐trigger group (mean difference, 0.36 L/min; 95% confidence interval (CI.95), −0.05 to 0.78; P = .092; n = 42). At the nadir ScO 2 ‐level, CO was 11.9% higher in the low‐trigger group (mean difference, 0.58 L/min; CI.95, 0.10‐1.07; P = .024). No difference in oxygen delivery was detected between trial groups (MD, 1.39 dL O2 /min; CI.95, −6.16 to 8.93; P = .721). Conclusion Vascular surgical patients exposed to restrictive RBC transfusion elicit the expected increase in CO making it unlikely that their potentially limited cardiac capacity explains the associated ScO 2 decrease. Background During vascular surgery, restricted red‐cell transfusion reduces frontal lobe oxygen (ScO2) saturation as determined by near‐infrared spectroscopy. We evaluated whether inadequate increase in cardiac output (CO) following haemodilution explains reduction in ScO2. Methods This is a post‐hoc analysis of data from the Transfusion in Vascular surgery (TV) Trial where patients were randomized on haemoglobin drop below 9.7 g/dL to red‐cell transfusion at haemoglobin below 8.0 (low‐trigger) vs 9.7 g/dL (high‐trigger). Fluid administration was guided by optimizing stroke volume. We compared mean intraoperative levels of CO, haemoglobin, oxygen delivery, and CO at nadir ScO2 with linear regression adjusted for age, operation type and baseline. Data for 46 patients randomized before end of surgery were included for analysis. Results The low‐trigger resulted in a 7.1% lower mean intraoperative haemoglobin level (mean difference, −0.74 g/dL; P < .001) and reduced volume of red‐cell transfused (median [inter‐quartile range], 0 [0‐300] vs 450 mL [300‐675]; P < .001) compared with the high‐trigger group. Mean CO during surgery was numerically 7.3% higher in the low‐trigger compared with the high‐trigger group (mean difference, 0.36 L/min; 95% confidence interval (CI.95), −0.05 to 0.78; P = .092; n = 42). At the nadir ScO2‐level, CO was 11.9% higher in the low‐trigger group (mean difference, 0.58 L/min; CI.95, 0.10‐1.07; P = .024). No difference in oxygen delivery was detected between trial groups (MD, 1.39 dLO2/min; CI.95, −6.16 to 8.93; P = .721). Conclusion Vascular surgical patients exposed to restrictive RBC transfusion elicit the expected increase in CO making it unlikely that their potentially limited cardiac capacity explains the associated ScO2 decrease. BackgroundDuring vascular surgery, restricted red‐cell transfusion reduces frontal lobe oxygen (ScO2) saturation as determined by near‐infrared spectroscopy. We evaluated whether inadequate increase in cardiac output (CO) following haemodilution explains reduction in ScO2.MethodsThis is a post‐hoc analysis of data from the Transfusion in Vascular surgery (TV) Trial where patients were randomized on haemoglobin drop below 9.7 g/dL to red‐cell transfusion at haemoglobin below 8.0 (low‐trigger) vs 9.7 g/dL (high‐trigger). Fluid administration was guided by optimizing stroke volume. We compared mean intraoperative levels of CO, haemoglobin, oxygen delivery, and CO at nadir ScO2 with linear regression adjusted for age, operation type and baseline. Data for 46 patients randomized before end of surgery were included for analysis.ResultsThe low‐trigger resulted in a 7.1% lower mean intraoperative haemoglobin level (mean difference, −0.74 g/dL; P < .001) and reduced volume of red‐cell transfused (median [inter‐quartile range], 0 [0‐300] vs 450 mL [300‐675]; P < .001) compared with the high‐trigger group. Mean CO during surgery was numerically 7.3% higher in the low‐trigger compared with the high‐trigger group (mean difference, 0.36 L/min; 95% confidence interval (CI.95), −0.05 to 0.78; P = .092; n = 42). At the nadir ScO2‐level, CO was 11.9% higher in the low‐trigger group (mean difference, 0.58 L/min; CI.95, 0.10‐1.07; P = .024). No difference in oxygen delivery was detected between trial groups (MD, 1.39 dLO2/min; CI.95, −6.16 to 8.93; P = .721).ConclusionVascular surgical patients exposed to restrictive RBC transfusion elicit the expected increase in CO making it unlikely that their potentially limited cardiac capacity explains the associated ScO2 decrease. BACKGROUNDDuring vascular surgery, restricted red-cell transfusion reduces frontal lobe oxygen (ScO2 ) saturation as determined by near-infrared spectroscopy. We evaluated whether inadequate increase in cardiac output (CO) following haemodilution explains reduction in ScO2 . METHODSThis is a post-hoc analysis of data from the Transfusion in Vascular surgery (TV) Trial where patients were randomized on haemoglobin drop below 9.7 g/dL to red-cell transfusion at haemoglobin below 8.0 (low-trigger) vs 9.7 g/dL (high-trigger). Fluid administration was guided by optimizing stroke volume. We compared mean intraoperative levels of CO, haemoglobin, oxygen delivery, and CO at nadir ScO2 with linear regression adjusted for age, operation type and baseline. Data for 46 patients randomized before end of surgery were included for analysis. RESULTSThe low-trigger resulted in a 7.1% lower mean intraoperative haemoglobin level (mean difference, -0.74 g/dL; P < .001) and reduced volume of red-cell transfused (median [inter-quartile range], 0 [0-300] vs 450 mL [300-675]; P < .001) compared with the high-trigger group. Mean CO during surgery was numerically 7.3% higher in the low-trigger compared with the high-trigger group (mean difference, 0.36 L/min; 95% confidence interval (CI.95), -0.05 to 0.78; P = .092; n = 42). At the nadir ScO2 -level, CO was 11.9% higher in the low-trigger group (mean difference, 0.58 L/min; CI.95, 0.10-1.07; P = .024). No difference in oxygen delivery was detected between trial groups (MD, 1.39 dLO2 /min; CI.95, -6.16 to 8.93; P = .721). CONCLUSIONVascular surgical patients exposed to restrictive RBC transfusion elicit the expected increase in CO making it unlikely that their potentially limited cardiac capacity explains the associated ScO2 decrease. |
Author | Shahidi, Saeid Marcussen, Klaus V. Mortensen, Anette Hellemann, Dorthe Pedersen, Ole B. Ramsing, Benedicte G. U. Møller, Anders Wetterslev, Jørn Secher, Niels H. Nielsen, Henning B. |
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Cites_doi | 10.1056/NEJMoa1711818 10.1182/blood-2018-10-877530 10.1001/2013.jamainternmed.1001 10.1034/j.1399-6576.2002.460713.x 10.1016/j.jvs.2017.10.044 10.1097/ALN.0000000000001162 10.1136/bmj.i1351 10.1097/00000658-198402000-00016 10.1053/j.jvca.2017.02.187 10.1111/anae.14973 10.1186/s40635-017-0125-6 10.1097/MCA.0b013e3282f08e86 10.1097/SLA.0b013e3181e3e43f 10.1111/aas.12953 10.3389/fneur.2019.00560 10.1056/NEJMoa1012452 10.1016/j.jvs.2017.05.113 10.1016/S0140-6736(19)31795-7 10.1016/S0002-9610(99)00140-3 10.1097/ALN.0000000000002603 10.3389/fmed.2018.00064 10.1056/NEJMoa1406617 10.1097/EJA.0000000000001189 10.1213/ANE.0000000000003418 10.1097/ALN.0000000000000463 10.1097/SLA.0000000000002408 10.1113/jphysiol.2005.101121 10.1152/ajpregu.00270.2015 10.1016/S0002-9610(97)00073-1 10.1097/EJA.0b013e32835f4d5b |
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Copyright | 2020 The Acta Anaesthesiologica Scandinavica Foundation. Published by John Wiley & Sons Ltd 2020 The Acta Anaesthesiologica Scandinavica Foundation. Published by John Wiley & Sons Ltd. Copyright © 2021 The Acta Anaesthesiologica Scandinavica Foundation |
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Keywords | tissue oxygenation arterial occlusive disease abdominal aortic aneurysm anaesthesia erythrocyte transfusion |
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Notes | Funding information This work was supported by the local research fund of Region Zealand, Næstved, Denmark and by Region Zealand Health Research Fund (RSSF, PFI). The funds have had no role in study design, collection, management, analysis, or interpretation of data, writing of the report, or in the decision to submit the report for publication. ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-News-1 ObjectType-Feature-3 content type line 23 |
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References | 2017; 5 2007; 18 2017; 61 1997; 174 2019; 10 2017; 66 2015; 122 2006; 572 2020; 37 2014; 371 2019; 128 2016; 125 2018; 67 2017; 377 2017; 31 2018; 5 2020; 75 1984; 199 2002; 46 2013; 30 2016; 310 2016; 352 2010; 252 2013; 173 1999; 178 2019; 130 2017; 266 2019; 394 2019; 133 2011; 365 e_1_2_9_30_1 e_1_2_9_31_1 e_1_2_9_11_1 e_1_2_9_10_1 e_1_2_9_13_1 e_1_2_9_12_1 e_1_2_9_15_1 e_1_2_9_14_1 e_1_2_9_17_1 e_1_2_9_16_1 e_1_2_9_19_1 e_1_2_9_18_1 e_1_2_9_20_1 e_1_2_9_22_1 e_1_2_9_21_1 e_1_2_9_24_1 e_1_2_9_23_1 e_1_2_9_8_1 e_1_2_9_7_1 e_1_2_9_6_1 e_1_2_9_5_1 e_1_2_9_4_1 e_1_2_9_3_1 e_1_2_9_2_1 e_1_2_9_9_1 e_1_2_9_26_1 e_1_2_9_25_1 e_1_2_9_28_1 e_1_2_9_27_1 e_1_2_9_29_1 |
References_xml | – volume: 66 start-page: 1836 year: 2017 end-page: 1843 article-title: Effect of postoperative anemia and baseline cardiac risk on serious adverse outcomes after major vascular interventions publication-title: J Vasc Surg – volume: 31 start-page: 1155 year: 2017 end-page: 1165 article-title: Near‐infrared spectroscopy in adult cardiac surgery patients: a systematic review and meta‐analysis publication-title: J Cardiothorac Vasc Anesth – volume: 122 start-page: 241 year: 2015 end-page: 275 article-title: Practice guidelines for perioperative blood management: an updated report by the American Society of Anesthesiologists Task Force on Perioperative Blood Management* publication-title: Anesthesiology – volume: 67 start-page: 2 year: 2018 end-page: 77.e2 article-title: The Society for Vascular Surgery practice guidelines on the care of patients with an abdominal aortic aneurysm publication-title: J Vasc Surg – volume: 37 start-page: 482 year: 2020 end-page: 490 article-title: Internal carotid artery blood flow is enhanced by elevating blood pressure during combined propofol‐remifentanil and thoracic epidural anaesthesia: a randomised cross‐over trial publication-title: Eur J Anaesthesiol – volume: 371 start-page: 1381 year: 2014 end-page: 1391 article-title: Lower versus higher hemoglobin threshold for transfusion in septic shock publication-title: N Engl J Med – volume: 377 start-page: 2133 year: 2017 end-page: 2144 article-title: Restrictive or liberal red‐cell transfusion for cardiac surgery publication-title: N Engl J Med – volume: 5 start-page: 12 year: 2017 article-title: Experimental assessment of oxygen homeostasis during acute hemodilution: the integrated role of hemoglobin concentration and blood pressure publication-title: Intensive Care Med Exp – volume: 18 start-page: 571 year: 2007 end-page: 576 article-title: The prevalence and prognosis of unrecognized myocardial infarction and silent myocardial ischemia in patients undergoing major vascular surgery publication-title: Coron Artery Dis – volume: 174 start-page: 143 year: 1997 end-page: 148 article-title: A prospective, randomized trial limiting perioperative red blood cell transfusions in vascular patients publication-title: Am J Surg – volume: 199 start-page: 223 year: 1984 end-page: 233 article-title: Coronary artery disease in peripheral vascular patients. A classification of 1000 coronary angiograms and results of surgical management publication-title: Ann Surg – volume: 10 year: 2019 article-title: Cerebrovascular disease and perioperative neurologic vulnerability: a prospective cohort study publication-title: Front Neurol – volume: 572 start-page: 295 year: 2006 end-page: 305 article-title: Erythrocytes and the regulation of human skeletal muscle blood flow and oxygen delivery: role of erythrocyte count and oxygenation state of haemoglobin publication-title: J Physiol – volume: 30 start-page: 270 year: 2013 end-page: 382 article-title: Management of severe perioperative bleeding: guidelines from the European Society of Anaesthesiology publication-title: Eur J Anaesthesiol – volume: 46 start-page: 831 year: 2002 end-page: 835 article-title: Effects of propofol on cerebral blood flow and the metabolic rate of oxygen in humans publication-title: Acta Anaesthesiol Scand – volume: 173 start-page: 132 year: 2013 end-page: 139 article-title: Association of blood transfusion with increased mortality in myocardial infarction: a meta‐analysis and diversity‐adjusted study sequential analysis publication-title: JAMA Intern Med – volume: 125 start-page: 46 year: 2016 end-page: 61 article-title: Restrictive versus liberal transfusion strategy in the perioperative and acute care settings: a context‐specific systematic review and meta‐analysis of randomized controlled trials publication-title: Anesthesiology – volume: 61 start-page: 952 year: 2017 end-page: 961 article-title: Low vs. high haemoglobin trigger for transfusion in vascular surgery: protocol for a randomised trial publication-title: Acta Anaesthesiol Scand – volume: 178 start-page: 194 year: 1999 end-page: 196 article-title: The prevalence of carotid artery stenosis in patients undergoing aortic reconstruction publication-title: Am J Surg – volume: 128 start-page: 1081 year: 2019 end-page: 1088 article-title: Impact of 2 distinct levels of mean arterial pressure on near‐infrared spectroscopy during cardiac surgery: secondary outcome from a randomized clinical trial publication-title: Anesth Analg – volume: 5 year: 2018 article-title: Cardiac output monitoring by pulse contour analysis, the technical basics of less‐invasive techniques publication-title: Front Med (Lausanne) – volume: 133 start-page: 2639 year: 2019 end-page: 2650 article-title: Low vs high hemoglobin trigger for transfusion in vascular surgery: a randomized clinical feasibility trial publication-title: Blood – volume: 130 start-page: 825 year: 2019 end-page: 832 article-title: Perioperative fluid therapy for major surgery publication-title: Anesthesiology – volume: 75 start-page: 433 year: 2020 end-page: 437 article-title: Restrictive blood transfusion ‐ is less really more? publication-title: Anaesthesia – volume: 365 start-page: 2453 year: 2011 end-page: 2462 article-title: Liberal or restrictive transfusion in high‐risk patients after hip surgery publication-title: N Engl J Med – volume: 266 start-page: 595 year: 2017 end-page: 602 article-title: Transfusion requirement in burn care evaluation (TRIBE): a multicenter randomized prospective trial of blood transfusion in major burn injury publication-title: Ann Surg – volume: 352 year: 2016 article-title: Effect of restrictive versus liberal transfusion strategies on outcomes in patients with cardiovascular disease in a non‐cardiac surgery setting: systematic review and meta‐analysis publication-title: BMJ – volume: 252 start-page: 11 year: 2010 end-page: 17 article-title: Operative blood loss, blood transfusion, and 30‐day mortality in older patients after major noncardiac surgery publication-title: Ann Surg – volume: 310 start-page: R398 year: 2016 end-page: R413 article-title: Hypoxemia, oxygen content, and the regulation of cerebral blood flow publication-title: Am J Physiol Regul Integr Comp Physiol – volume: 394 start-page: 1022 year: 2019 end-page: 1029 article-title: Perioperative covert stroke in patients undergoing non‐cardiac surgery (NeuroVISION): a prospective cohort study publication-title: Lancet – ident: e_1_2_9_14_1 doi: 10.1056/NEJMoa1711818 – ident: e_1_2_9_2_1 doi: 10.1182/blood-2018-10-877530 – ident: e_1_2_9_12_1 doi: 10.1001/2013.jamainternmed.1001 – ident: e_1_2_9_27_1 doi: 10.1034/j.1399-6576.2002.460713.x – ident: e_1_2_9_10_1 doi: 10.1016/j.jvs.2017.10.044 – ident: e_1_2_9_6_1 doi: 10.1097/ALN.0000000000001162 – ident: e_1_2_9_19_1 doi: 10.1136/bmj.i1351 – ident: e_1_2_9_4_1 doi: 10.1097/00000658-198402000-00016 – ident: e_1_2_9_29_1 doi: 10.1053/j.jvca.2017.02.187 – ident: e_1_2_9_11_1 doi: 10.1111/anae.14973 – ident: e_1_2_9_24_1 doi: 10.1186/s40635-017-0125-6 – ident: e_1_2_9_3_1 doi: 10.1097/MCA.0b013e3282f08e86 – ident: e_1_2_9_20_1 doi: 10.1097/SLA.0b013e3181e3e43f – ident: e_1_2_9_15_1 doi: 10.1111/aas.12953 – ident: e_1_2_9_25_1 doi: 10.3389/fneur.2019.00560 – ident: e_1_2_9_13_1 doi: 10.1056/NEJMoa1012452 – ident: e_1_2_9_7_1 doi: 10.1016/j.jvs.2017.05.113 – ident: e_1_2_9_30_1 doi: 10.1016/S0140-6736(19)31795-7 – ident: e_1_2_9_5_1 doi: 10.1016/S0002-9610(99)00140-3 – ident: e_1_2_9_17_1 doi: 10.1097/ALN.0000000000002603 – ident: e_1_2_9_31_1 doi: 10.3389/fmed.2018.00064 – ident: e_1_2_9_18_1 doi: 10.1056/NEJMoa1406617 – ident: e_1_2_9_26_1 doi: 10.1097/EJA.0000000000001189 – ident: e_1_2_9_28_1 doi: 10.1213/ANE.0000000000003418 – ident: e_1_2_9_8_1 doi: 10.1097/ALN.0000000000000463 – ident: e_1_2_9_22_1 doi: 10.1097/SLA.0000000000002408 – ident: e_1_2_9_16_1 doi: 10.1113/jphysiol.2005.101121 – ident: e_1_2_9_23_1 doi: 10.1152/ajpregu.00270.2015 – ident: e_1_2_9_21_1 doi: 10.1016/S0002-9610(97)00073-1 – ident: e_1_2_9_9_1 doi: 10.1097/EJA.0b013e32835f4d5b |
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Snippet | Background
During vascular surgery, restricted red‐cell transfusion reduces frontal lobe oxygen (ScO2) saturation as determined by near‐infrared spectroscopy.... During vascular surgery, restricted red-cell transfusion reduces frontal lobe oxygen (ScO ) saturation as determined by near-infrared spectroscopy. We... Abstract Background During vascular surgery, restricted red‐cell transfusion reduces frontal lobe oxygen (ScO 2 ) saturation as determined by near‐infrared... BackgroundDuring vascular surgery, restricted red‐cell transfusion reduces frontal lobe oxygen (ScO2) saturation as determined by near‐infrared spectroscopy.... BACKGROUNDDuring vascular surgery, restricted red-cell transfusion reduces frontal lobe oxygen (ScO2 ) saturation as determined by near-infrared spectroscopy.... |
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SubjectTerms | abdominal aortic aneurysm anaesthesia arterial occlusive disease Carbon monoxide Cardiac output Confidence intervals erythrocyte transfusion Frontal lobe Heart Hemoglobin Infrared spectroscopy Oxygen Statistical analysis Stroke Stroke volume Surgery tissue oxygenation Transfusion Vascular surgery |
Title | Effect of low vs high haemoglobin transfusion trigger on cardiac output in patients undergoing elective vascular surgery: Post‐hoc analysis of a randomized trial |
URI | https://onlinelibrary.wiley.com/doi/abs/10.1111%2Faas.13733 https://www.ncbi.nlm.nih.gov/pubmed/33141936 https://www.proquest.com/docview/2487437160/abstract/ https://search.proquest.com/docview/2457665713 |
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