Parkinson's Disease Is Associated with Impaired Gut–Blood Barrier for Short‐Chain Fatty Acids

• Published in: Movement disorders Vol. 37; no. 8; pp. 1634 - 1643
• Main Authors: Yang, Xiaodong, Ai, Penghui, He, Xiaoqin, Mo, Chengjun, Zhang, Yi, Xu, Shaoqing, Lai, Yiqiu, Qian, Yiwei, Xiao, Qin
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.08.2022; Wiley Subscription Services, Inc
• Subjects: a1-antitrypsin; Butyric acid; Constipation; Constipation - etiology; Digestive system; Fatty acids; Fatty Acids, Volatile - metabolism; Feces; Feces - chemistry; Gas chromatography; Gastrointestinal tract; gut–blood barrier permeability; Humans; Intestinal microflora; Mass spectroscopy; Microbiota; Movement disorders; Neurodegenerative diseases; Parkinson Disease - complications; Parkinson's disease; Permeability; Plasma; Propionates - analysis; Propionic acid; short‐chain fatty acid; Valeric acid; constipation; gut-blood barrier permeability; short-chain fatty acid; Parkinson's disease

ABSTRACT Background Short‐chain fatty acids (SCFAs) produced by gut microbiota are reduced in feces but paradoxically increased in plasma of patients with Parkinson's disease (PD), which may stem from intestinal wall leakage. Gut function should be taken into consideration when conducting micro...