Using laser capture microdissection to study fiber specific signaling in locomotor muscle in COPD: A pilot study - Mohan, Divya; Lewis, Amy; Patel, Mehul S.; Curtis, Katrina J.; Lee, Jen Y.; Hopkinson, Nicholas S.; Wilkinson, Ian B.; Kemp, Paul R.; Polkey, Michael I. (Muscle & nerve, 2017)
Keywords: Adult; Aged; Aged, 80 and over; Biopsy; Case-Control Studies; Chronic obstructive pulmonary disease; Degradation; fiber type; Fibers; Gene expression; Gene Expression Regulation - physiology; Humans; Intracellular Signaling Peptides and Proteins - genetics; Intracellular Signaling Peptides and Proteins - metabolism; Laser Capture Microdissection; Lung diseases; Male; microdissection; Middle Aged; Muscle Fibers, Skeletal - classification; Muscle Fibers, Skeletal - metabolism; Muscle Fibers, Skeletal - pathology; Muscle Proteins - genetics; Muscle Proteins - metabolism; muscle weakness; Muscle, Skeletal - physiopathology; Myosin Heavy Chains - metabolism; Obstructive lung disease; Phosphotransferases (Alcohol Group Acceptor) - genetics; Phosphotransferases (Alcohol Group Acceptor) - metabolism; Pilot Projects; Polymerase chain reaction; Protein biosynthesis; Protein synthesis; Pulmonary Disease, Chronic Obstructive - pathology; Quadriceps muscle; Signal Transduction - physiology; SKP Cullin F-Box Protein Ligases - genetics; SKP Cullin F-Box Protein Ligases - metabolism; Statistics, Nonparametric; Temperature effects; fiber type; humans; microdissection; muscle weakness; quadriceps muscle