Efficacy of topiramate in reducing second‐generation antipsychotic‐associated weight gain among children: A systematic review and meta‐analysis

• Published in: Diabetes, obesity & metabolism Vol. 26; no. 6; pp. 2292 - 2304
• Main Authors: Costa, Gabriel P. A., Moraes, Vitor R. Y., Assunção, Beatriz R., Burns, Nora, Laique, Sobia, Sengupta, Shreya, Anand, Akhil, Nunes, Julio C.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.06.2024; Wiley Subscription Services, Inc
• Subjects: antipsychotic; Antipsychotics; Body mass index; Children; Cholesterol; Cognitive ability; Meta-analysis; metabolism; Placebos; Psychotropic drugs; Reviews; Side effects; Statistical analysis; Systematic review; Topiramate; Triglycerides; Weight; weight gain; weight‐reducing agents; antipsychotic; metabolism; weight-reducing agents; weight gain; topiramate

Aims To conduct a systematic review and meta‐analysis with the aim of synthesizing existing data on the efficacy and safety of topiramate as an adjunctive treatment for reducing second‐generation antipsychotic (SGA)‐associated weight gain in children aged 4–18 years. Methods We conducted a comprehen...