Treatment of cutaneous leishmaniasis with a sequential scheme of pentamidine and tamoxifen in an area with a predominance of Leishmania (Viannia) guyanensis: A randomised, non‐inferiority clinical trial

• Published in: Tropical medicine & international health Vol. 28; no. 12; pp. 871 - 880
• Main Authors: Pennini, Silmara Navarro, Oliveira Guerra, Jorge Augusto, Rebello, Paula Frassinetti Bessa, Abtibol‐Bernardino, Marília Rosa, Castro, Luigui Lima, Silva Balieiro, Antonio Alcirley, Oliveira Ferreira, Cynthia, Noronha, Ariani Batista, Santos da Silva, Camila Gurgel, Leturiondo, André Luiz, Vital de Jesus, Denison, Araújo Santos, Felipe Jules, Chrusciak‐Talhari, Anette, Guerra, Maria Das Graças Vale Barbosa, Talhari, Sinésio
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.12.2023
• Subjects: Antiprotozoal Agents; Clinical outcomes; clinical trial; Clinical trials; Cutaneous leishmaniasis; Healing; Humans; Leishmania; Leishmania guyanensis; Leishmaniasis, Cutaneous - drug therapy; Leishmaniasis, Cutaneous - pathology; Parasitic diseases; Patients; PCR; Pentamidine; Pentamidine - therapeutic use; Tamoxifen; Tamoxifen - therapeutic use; Telemedicine; treatment; Vector-borne diseases; Western Amazon; clinical trial; telemedicine; treatment; Western Amazon; cutaneous leishmaniasis; PCR; tamoxifen

Objective To determine whether a combination of a single intramuscular (IM) dose of pentamidine (7 mg/kg) followed by oral tamoxifen 40 mg/day for 20 days is non‐inferior to three IM doses of pentamidine 7 mg/kg in the treatment of cutaneous leishmaniasis with a margin of 15%. Methods Phase II, rand...