T‐cell receptor diversity and allergen sensitivity in childhood asthma and atopic dermatitis

• Published in: Pediatric allergy and immunology Vol. 35; no. 5; pp. e14143 - n/a
• Main Authors: Chen, Pei‐Ling, Hung, Shuen‐Iu, Chung, Wen‐Hung, Chen, Chun‐Bing, Kuo, Chieh‐Ni, Lin, Yin‐Ku, Chiu, Chih‐Yung
• Format: Journal Article
• Language: English
• Published: England Wiley Subscription Services, Inc 01.05.2024
• Subjects: allergen; Allergens; Allergens - immunology; Allergies; Animals; Antigens; Asthma; Asthma - genetics; Asthma - immunology; Atopic dermatitis; Case-Control Studies; Child; Child, Preschool; Childhood; Children; Childrens health; Complementarity Determining Regions - genetics; Complementarity Determining Regions - immunology; Complementarity-determining region 3; Dermatitis; Dermatitis, Atopic - genetics; Dermatitis, Atopic - immunology; diversity; Female; Gene expression; Genotype & phenotype; Humans; Immune response; Immune response (cell-mediated); Immunoglobulin E; Immunoglobulin E - blood; Immunoglobulin E - immunology; Immunotherapy; Male; Phenotypes; Precision medicine; Receptors, Antigen, T-Cell - genetics; Receptors, Antigen, T-Cell - immunology; Sensitivity analysis; T cell receptors; T‐cell receptor; Variable region; allergen; atopic dermatitis; diversity; asthma; T‐cell receptor

Background Childhood allergies of asthma and atopic dermatitis (AD) involve an overactive T‐cell immune response triggered by allergens. However, the impact of T‐cell receptor (TCR) repertoires on allergen sensitization and their role in mediating different phenotypes of asthma and AD in early child...