Epidemiology, risk factors, and molecular characterization of occult hepatitis B infection among anti‐hepatitis B core antigen alone subjects
Objectives Features of occult hepatitis B virus (HBV) infection among the anti‐hepatitis B core antigen (anti‐HBc) positives have yet to be described in more details. This study aimed to determine the molecular prevalence of occult HBV infection (OBI), and association to risk factors among seroposit...
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| Published in | Journal of medical virology Vol. 91; no. 4; pp. 615 - 622 |
|---|---|
| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Wiley Subscription Services, Inc
01.04.2019
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| Subjects | |
| Online Access | Get full text |
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| Abstract | Objectives
Features of occult hepatitis B virus (HBV) infection among the anti‐hepatitis B core antigen (anti‐HBc) positives have yet to be described in more details. This study aimed to determine the molecular prevalence of occult HBV infection (OBI), and association to risk factors among seropositives for anti‐HBc.
Methods
This was part of a community‐based screening project that included 5234 cases. All participants completed a questionnaire on demographic and socio‐epidemiological information. Then, the blood samples were collected and tested for anti‐HBc and HBsAg using ELISA method. To identify OBI, nested‐polymerase chain reaction (PCR) assays were performed for HBV‐S and X genes, and viral load was determined using an in‐house real‐time PCR. Sequencing and phylogenetic analysis have been implemented for genotyping.
Results
Overall, 596 cases, positive only for anti‐HBc were included in the study. OBI was detected among 61 cases (10.2%). The genotype and subgenotype of HBV among all of them was D1, except one that was D4. Most of them had low viral loads ranged from 1.2 × 102 to 1.34 × 10
3 copies/mL; 19.6% had undetectable viral loads. Important mutations in surface protein and reverse transcriptase were sI92T, sQ129H, rtL80I, rtS85F, rtL91I. The prevalence of OBI was related to some risk factors, such as tattooing (P = 0.02), sexual activities (P = 0.009), and diabetes (P = 0.031).
Conclusion
Our study suggests that OBI should be considered among anti‐HBc seropositive subjects. This form of HBV infection was accompanied with some mutations, risk factors, and diseases. However, further investigations are needed to determine virological importance of documented mutations. |
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| AbstractList | Features of occult hepatitis B virus (HBV) infection among the anti-hepatitis B core antigen (anti-HBc) positives have yet to be described in more details. This study aimed to determine the molecular prevalence of occult HBV infection (OBI), and association to risk factors among seropositives for anti-HBc.
This was part of a community-based screening project that included 5234 cases. All participants completed a questionnaire on demographic and socio-epidemiological information. Then, the blood samples were collected and tested for anti-HBc and HBsAg using ELISA method. To identify OBI, nested-polymerase chain reaction (PCR) assays were performed for HBV-S and X genes, and viral load was determined using an in-house real-time PCR. Sequencing and phylogenetic analysis have been implemented for genotyping.
Overall, 596 cases, positive only for anti-HBc were included in the study. OBI was detected among 61 cases (10.2%). The genotype and subgenotype of HBV among all of them was D1, except one that was D4. Most of them had low viral loads ranged from 1.2 × 10
to 1.34 × 10
copies/mL; 19.6% had undetectable viral loads. Important mutations in surface protein and reverse transcriptase were sI92T, sQ129H, rtL80I, rtS85F, rtL91I. The prevalence of OBI was related to some risk factors, such as tattooing (P = 0.02), sexual activities (P = 0.009), and diabetes (P = 0.031).
Our study suggests that OBI should be considered among anti-HBc seropositive subjects. This form of HBV infection was accompanied with some mutations, risk factors, and diseases. However, further investigations are needed to determine virological importance of documented mutations. Features of occult hepatitis B virus (HBV) infection among the anti-hepatitis B core antigen (anti-HBc) positives have yet to be described in more details. This study aimed to determine the molecular prevalence of occult HBV infection (OBI), and association to risk factors among seropositives for anti-HBc.OBJECTIVESFeatures of occult hepatitis B virus (HBV) infection among the anti-hepatitis B core antigen (anti-HBc) positives have yet to be described in more details. This study aimed to determine the molecular prevalence of occult HBV infection (OBI), and association to risk factors among seropositives for anti-HBc.This was part of a community-based screening project that included 5234 cases. All participants completed a questionnaire on demographic and socio-epidemiological information. Then, the blood samples were collected and tested for anti-HBc and HBsAg using ELISA method. To identify OBI, nested-polymerase chain reaction (PCR) assays were performed for HBV-S and X genes, and viral load was determined using an in-house real-time PCR. Sequencing and phylogenetic analysis have been implemented for genotyping.METHODSThis was part of a community-based screening project that included 5234 cases. All participants completed a questionnaire on demographic and socio-epidemiological information. Then, the blood samples were collected and tested for anti-HBc and HBsAg using ELISA method. To identify OBI, nested-polymerase chain reaction (PCR) assays were performed for HBV-S and X genes, and viral load was determined using an in-house real-time PCR. Sequencing and phylogenetic analysis have been implemented for genotyping.Overall, 596 cases, positive only for anti-HBc were included in the study. OBI was detected among 61 cases (10.2%). The genotype and subgenotype of HBV among all of them was D1, except one that was D4. Most of them had low viral loads ranged from 1.2 × 102 to 1.34 × 10 3 copies/mL; 19.6% had undetectable viral loads. Important mutations in surface protein and reverse transcriptase were sI92T, sQ129H, rtL80I, rtS85F, rtL91I. The prevalence of OBI was related to some risk factors, such as tattooing (P = 0.02), sexual activities (P = 0.009), and diabetes (P = 0.031).RESULTSOverall, 596 cases, positive only for anti-HBc were included in the study. OBI was detected among 61 cases (10.2%). The genotype and subgenotype of HBV among all of them was D1, except one that was D4. Most of them had low viral loads ranged from 1.2 × 102 to 1.34 × 10 3 copies/mL; 19.6% had undetectable viral loads. Important mutations in surface protein and reverse transcriptase were sI92T, sQ129H, rtL80I, rtS85F, rtL91I. The prevalence of OBI was related to some risk factors, such as tattooing (P = 0.02), sexual activities (P = 0.009), and diabetes (P = 0.031).Our study suggests that OBI should be considered among anti-HBc seropositive subjects. This form of HBV infection was accompanied with some mutations, risk factors, and diseases. However, further investigations are needed to determine virological importance of documented mutations.CONCLUSIONOur study suggests that OBI should be considered among anti-HBc seropositive subjects. This form of HBV infection was accompanied with some mutations, risk factors, and diseases. However, further investigations are needed to determine virological importance of documented mutations. ObjectivesFeatures of occult hepatitis B virus (HBV) infection among the anti‐hepatitis B core antigen (anti‐HBc) positives have yet to be described in more details. This study aimed to determine the molecular prevalence of occult HBV infection (OBI), and association to risk factors among seropositives for anti‐HBc.MethodsThis was part of a community‐based screening project that included 5234 cases. All participants completed a questionnaire on demographic and socio‐epidemiological information. Then, the blood samples were collected and tested for anti‐HBc and HBsAg using ELISA method. To identify OBI, nested‐polymerase chain reaction (PCR) assays were performed for HBV‐S and X genes, and viral load was determined using an in‐house real‐time PCR. Sequencing and phylogenetic analysis have been implemented for genotyping.ResultsOverall, 596 cases, positive only for anti‐HBc were included in the study. OBI was detected among 61 cases (10.2%). The genotype and subgenotype of HBV among all of them was D1, except one that was D4. Most of them had low viral loads ranged from 1.2 × 102 to 1.34 × 103 copies/mL; 19.6% had undetectable viral loads. Important mutations in surface protein and reverse transcriptase were sI92T, sQ129H, rtL80I, rtS85F, rtL91I. The prevalence of OBI was related to some risk factors, such as tattooing (P = 0.02), sexual activities (P = 0.009), and diabetes (P = 0.031).ConclusionOur study suggests that OBI should be considered among anti‐HBc seropositive subjects. This form of HBV infection was accompanied with some mutations, risk factors, and diseases. However, further investigations are needed to determine virological importance of documented mutations. Objectives Features of occult hepatitis B virus (HBV) infection among the anti‐hepatitis B core antigen (anti‐HBc) positives have yet to be described in more details. This study aimed to determine the molecular prevalence of occult HBV infection (OBI), and association to risk factors among seropositives for anti‐HBc. Methods This was part of a community‐based screening project that included 5234 cases. All participants completed a questionnaire on demographic and socio‐epidemiological information. Then, the blood samples were collected and tested for anti‐HBc and HBsAg using ELISA method. To identify OBI, nested‐polymerase chain reaction (PCR) assays were performed for HBV‐S and X genes, and viral load was determined using an in‐house real‐time PCR. Sequencing and phylogenetic analysis have been implemented for genotyping. Results Overall, 596 cases, positive only for anti‐HBc were included in the study. OBI was detected among 61 cases (10.2%). The genotype and subgenotype of HBV among all of them was D1, except one that was D4. Most of them had low viral loads ranged from 1.2 × 102 to 1.34 × 10 3 copies/mL; 19.6% had undetectable viral loads. Important mutations in surface protein and reverse transcriptase were sI92T, sQ129H, rtL80I, rtS85F, rtL91I. The prevalence of OBI was related to some risk factors, such as tattooing (P = 0.02), sexual activities (P = 0.009), and diabetes (P = 0.031). Conclusion Our study suggests that OBI should be considered among anti‐HBc seropositive subjects. This form of HBV infection was accompanied with some mutations, risk factors, and diseases. However, further investigations are needed to determine virological importance of documented mutations. |
| Author | Ziaee, Masood Ebrahimzadeh, Azadeh Azarkar, Zohreh Sharifzadeh, Gholamreza Javanmard, Davod |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30345529$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_1093_ve_veae009 crossref_primary_10_3390_v16040529 crossref_primary_10_5812_hepatmon_101722 crossref_primary_10_5812_hepatmon_100899 crossref_primary_10_2217_fvl_2020_0386 crossref_primary_10_3390_diagnostics14070728 crossref_primary_10_1002_hsr2_1466 crossref_primary_10_1002_jmv_25470 crossref_primary_10_5812_ijcm_137093 |
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| Keywords | prevalence Iran occult hepatitis B virus occult hepatitis B virus infection diabetes genotype |
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| References_xml | – volume: 46 start-page: 27 issue: 1 year: 2008 ident: e_1_2_7_1_23_1 article-title: Occult hepatitis B virus infection among blood donors with antibodies to hepatitis B core antigen publication-title: Acta Med Iran – ident: e_1_2_7_1_30_1 doi: 10.1097/MEG.0b013e3282f55e1e – ident: e_1_2_7_1_6_1 doi: 10.3748/wjg.v17.i15.1927 – ident: e_1_2_7_1_34_1 doi: 10.3748/wjg.v20.i24.7653 – ident: e_1_2_7_1_40_1 doi: 10.1186/s12985-014-0206-z – ident: e_1_2_7_1_21_1 doi: 10.3855/jidc.728 – volume: 16 start-page: e36452 issue: 9 year: 2016 ident: e_1_2_7_1_16_1 article-title: Seroprevalence and risk factors for hepatitis B in an adult population: the first report from Birjand, South Khorasan, Iran publication-title: Hepatitis Mon – ident: e_1_2_7_1_7_1 doi: 10.1053/jhep.2001.25172 – volume: 11 start-page: 90 issue: 1 year: 2009 ident: e_1_2_7_1_22_1 article-title: Occult hepatitis B virus infection among anti‐HBc only positive individuals in the Southeast of Iran in high prevalence of HBV infection region publication-title: Iran Red Crescent Med J – ident: e_1_2_7_1_29_1 doi: 10.1128/JCM.40.11.4068-4071.2002 – ident: e_1_2_7_1_25_1 doi: 10.1002/jmv.24372 – ident: e_1_2_7_1_41_1 doi: 10.1186/1743-422X-8-281 – ident: e_1_2_7_1_33_1 doi: 10.1016/j.antiviral.2011.10.022 – ident: e_1_2_7_1_8_1 doi: 10.1016/j.jhep.2005.06.016 – ident: e_1_2_7_1_44_1 doi: 10.1111/j.1365-2893.2012.01616.x – ident: e_1_2_7_1_3_1 doi: 10.5812/jjm.11648 – ident: e_1_2_7_1_42_1 doi: 10.1016/j.jhep.2009.05.020 – ident: e_1_2_7_1_12_1 doi: 10.4254/wjh.v6.i12.860 – ident: e_1_2_7_1_31_1 doi: 10.1016/S0213-005X(08)76514-5 – ident: e_1_2_7_1_35_1 doi: 10.1128/JVI.00678-09 – ident: e_1_2_7_1_43_1 doi: 10.1016/j.jhep.2008.07.014 – volume: 10 start-page: e40816 issue: 2 year: 2017 ident: e_1_2_7_1_15_1 article-title: Occult hepatitis B infection in hepatitis C patients with hematological disorders publication-title: Jundishapur J Microbiol – ident: e_1_2_7_1_13_1 doi: 10.1007/s00277-009-0806-7 – ident: e_1_2_7_1_19_1 doi: 10.1016/j.ijid.2009.05.011 – ident: e_1_2_7_1_10_1 doi: 10.4166/kjg.2013.61.4.209 – ident: e_1_2_7_1_4_1 doi: 10.1046/j.1537-2995.1993.33593255593.x – ident: e_1_2_7_1_17_1 doi: 10.1016/j.ejmhg.2013.06.001 – volume: 16 start-page: e37806 issue: 10 year: 2016 ident: e_1_2_7_1_32_1 article-title: Genotyping and mutation pattern in the overlapping MHR region of HBV isolates in Southern Khorasan, Eastern Iran publication-title: Hepatitis Mon – ident: e_1_2_7_1_18_1 doi: 10.1093/molbev/msw054 – volume: 123 start-page: 37 issue: 1 year: 2006 ident: e_1_2_7_1_24_1 article-title: Anti‐HBc & HBV‐DNA detection in blood donors negative for hepatitis B virus surface antigen in reducing risk of transfusion associated HBV infection publication-title: Indian J Med Res – ident: e_1_2_7_1_36_1 doi: 10.1002/jmv.24623 – ident: e_1_2_7_1_2_1 doi: 10.3748/wjg.v17.i12.1553 – volume: 16 start-page: e34763 issue: 3 year: 2016 ident: e_1_2_7_1_20_1 article-title: Characterization of occult hepatitis B infection among injecting drug users in Tehran, Iran publication-title: Hepatitis Mon – ident: e_1_2_7_1_11_1 doi: 10.1111/j.1478-3231.2008.01699.x – ident: e_1_2_7_1_26_1 doi: 10.1186/1743-422X-7-204 – ident: e_1_2_7_1_45_1 doi: 10.1053/jhep.2002.36780 – ident: e_1_2_7_1_38_1 doi: 10.1186/1743-422X-10-56 – volume: 9 start-page: 14283 issue: 7 year: 2016 ident: e_1_2_7_1_37_1 article-title: Comparison of pyrosequencing and Sanger sequencing for HBV DNA genotyping and resistance mutations publication-title: Int J Clin Exp Med – ident: e_1_2_7_1_46_1 doi: 10.1136/gut.2004.052167 – ident: e_1_2_7_1_5_1 doi: 10.1371/journal.pone.0117275 – ident: e_1_2_7_1_9_1 doi: 10.1016/S0140-6736(94)90934-2 – ident: e_1_2_7_1_14_1 doi: 10.3904/kjm.2013.85.6.598 – ident: e_1_2_7_1_27_1 doi: 10.3324/haematol.11224 – ident: e_1_2_7_1_39_1 doi: 10.7883/yoken.JJID.2017.078 – ident: e_1_2_7_1_28_1 doi: 10.1016/j.jinf.2009.02.013 |
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Features of occult hepatitis B virus (HBV) infection among the anti‐hepatitis B core antigen (anti‐HBc) positives have yet to be described in more... Features of occult hepatitis B virus (HBV) infection among the anti-hepatitis B core antigen (anti-HBc) positives have yet to be described in more details.... ObjectivesFeatures of occult hepatitis B virus (HBV) infection among the anti‐hepatitis B core antigen (anti‐HBc) positives have yet to be described in more... Features of occult hepatitis B virus (HBV) infection among the anti-hepatitis B core antigen (anti-HBc) positives have yet to be described in more details.... |
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| Title | Epidemiology, risk factors, and molecular characterization of occult hepatitis B infection among anti‐hepatitis B core antigen alone subjects |
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