Construction of a three‐component regulatory network of transcribed ultraconserved regions for the identification of prognostic biomarkers in gastric cancer

• Published in: Journal of cellular biochemistry Vol. 124; no. 3; pp. 396 - 408
• Main Authors: Khalafiyan, Anis, Emadi‐Baygi, Modjtaba, Wolfien, Markus, Salehzadeh‐Yazdi, Ali, Nikpour, Parvaneh
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.03.2023
• Subjects: Adenocarcinoma; Adenocarcinoma - genetics; Animals; Apoptosis; Biomarkers; Biomarkers, Tumor - genetics; Cancer; Cell proliferation; Conserved sequence; Conserved Sequence - genetics; Enrichment; Gastric cancer; Gene expression; Gene Expression Regulation, Neoplastic; Gene regulation; Gene Regulatory Networks; Gene sequencing; Genomes; Humans; long noncoding RNA (lncRNA); Mice; MicroRNAs; MicroRNAs - genetics; miRNA; Neoplasms; Prognosis; Proteins; Rats; RNA, Long Noncoding; Statistical analysis; stomach cancer; Stomach Neoplasms - genetics; Survival; The Cancer Genome Atlas (TCGA); Therapeutic targets; transcribed ultraconserved regions (T‐UCRs); long noncoding RNA (lncRNA); transcribed ultraconserved regions (T-UCRs); stomach cancer; The Cancer Genome Atlas (TCGA)

Altered expression and functional roles of the transcribed ultraconserved regions (T‐UCRs), as genomic sequences with 100% conservation between the genomes of human, mouse, and rat, in the pathophysiology of neoplasms has already been investigated. Nevertheless, the relevance of the functions for T‐...