LncRNA‐MALAT1 Promotes Angiogenesis of Thyroid Cancer by Modulating Tumor‐Associated Macrophage FGF2 Protein Secretion

• Published in: Journal of cellular biochemistry Vol. 118; no. 12; pp. 4821 - 4830
• Main Authors: Huang, Jian‐kang, Ma, Ling, Song, Wen‐hua, Lu, Bang‐yu, Huang, Yu‐bin, Dong, Hui‐ming, Ma, Xiao‐kai, Zhu, Zheng‐zhi, Zhou, Rui
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.12.2017
• Subjects: Aged; ANGIOGENESIS; Assaying; Cancer; Cell adhesion & migration; Cell culture; Cell Line, Tumor; Cell proliferation; Cholecystokinin; Cytokines; Enzyme-linked immunosorbent assay; Female; FGF2; Fibroblast growth factor 2; Fibroblast Growth Factor 2 - genetics; Fibroblast Growth Factor 2 - secretion; Human Umbilical Vein Endothelial Cells - metabolism; Human Umbilical Vein Endothelial Cells - pathology; Humans; Inflammation; Interleukin 10; Interleukin 12; Leukocyte migration; Macrophages; Macrophages - pathology; Macrophages - secretion; MALAT1; Male; Middle Aged; Molecular modelling; Neoplasm Invasiveness; Neoplasm Proteins - genetics; Neoplasm Proteins - secretion; Neovascularization, Pathologic - genetics; Neovascularization, Pathologic - metabolism; Neovascularization, Pathologic - pathology; Proteins; RNA, Long Noncoding - genetics; RNA, Long Noncoding - metabolism; RNA, Neoplasm - genetics; RNA, Neoplasm - metabolism; siRNA; Thyroid; THYROID CANCER; Thyroid Neoplasms - blood supply; Thyroid Neoplasms - genetics; Thyroid Neoplasms - metabolism; Thyroid Neoplasms - pathology; Tumor necrosis factor; Tumors; TUMOR‐ASSOCIATED MACROPHAGES; TUMOR-ASSOCIATED MACROPHAGES; MALAT1; ANGIOGENESIS; FGF2; THYROID CANCER

ABSTRACT Tumor‐associated macrophages (TAMs) in the tumor microenvironment have been associated with enhanced tumor progression. In this study, we investigated the role and molecular mechanisms of MALAT1 in TAMs derived from thyroid cancer. The expression of MALAT1 and FGF2 in thyroid cancer tissues...