HDAC2 (Histone deacetylase 2): A critical factor in environmental enrichment‐mediated stroke recovery

• Published in: Journal of neurochemistry Vol. 155; no. 6; pp. 679 - 696
• Main Authors: Lin, Yu‐Hui, Yao, Meng‐Cheng, Wu, Hai‐Yin, Dong, Jian, Ni, Huan‐Yu, Kou, Xiao‐Lin, Chang, Lei, Luo, Chun‐Xia, Zhu, Dong‐Ya
• Format: Journal Article
• Language: English
• Published: England Blackwell Publishing Ltd 01.12.2020
• Subjects: Animals; Cortex (motor); Enrichment; Environment; environmental enrichment; Exposure; functional recovery; HDAC2 protein; Histone deacetylase; histone deacetylase 2; Histone Deacetylase 2 - metabolism; Histones; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neuroplasticity; Neurotrophic factors; Pyramidal tracts; Recovery; Recovery of function; Recovery of Function - physiology; Rewiring; Stroke; Stroke - enzymology; Stroke - pathology; Stroke - physiopathology; Trinucleotide repeats; Viruses; environmental enrichment; histone deacetylase 2; functional recovery; stroke; neuroplasticity

Environmental enrichment (EE) is a generally accepted strategy to promote stroke recovery and its beneficial effect is positively correlated with neuroplasticity. However, the mechanisms underlying it remain elusive. Histone deacetylase 2 (HDAC2), a negative regulator of neuroplasticity, is up‐regul...