The protective effect of fibroblast growth factor‐21 in alcoholic cardiomyopathy: a role in protecting cardiac mitochondrial function

• Published in: The Journal of pathology Vol. 253; no. 2; pp. 198 - 208
• Main Authors: Ferrer‐Curriu, Gemma, Guitart‐Mampel, Mariona, Rupérez, Celia, Zamora, Monica, Crispi, Fatima, Villarroya, Francesc, Fernández‐Solà, Joaquim, Garrabou, Gloria, Planavila, Anna
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 01.02.2021; Wiley Subscription Services, Inc
• Subjects: alcohol; Alcohol use; alcoholic cardiomyopathy; Animals; Cardiomegaly - pathology; Cardiomyopathy; Cardiomyopathy, Alcoholic - complications; Cardiomyopathy, Alcoholic - drug therapy; Cardiomyopathy, Alcoholic - pathology; Cardiovascular diseases; Congestive heart failure; FGF21; Fibroblast growth factors; Fibroblast Growth Factors - genetics; Fibroblast Growth Factors - metabolism; Fibroblasts; Fibrosis; Growth factors; heart; Heart Failure - etiology; Heart Failure - pathology; Humans; Hypertrophy; Klotho protein; Male; Mice; Mitochondria; Mitochondria - pathology; Myocardium; Myocytes; Myocytes, Cardiac - pathology; Oxidative Stress; Plasma levels; Protective Agents - therapeutic use; alcohol; hypertrophy; mitochondria; alcoholic cardiomyopathy; fibrosis; heart; oxidative stress; FGF21

Alcoholic cardiomyopathy (ACM) resulting from chronic alcohol misuse is one of the main contributors leading to heart failure and cardiovascular mortality. Fibroblast growth factor 21 (FGF21) is a well‐established cardioprotective factor. We aimed to study the role of FGF21 in experimentally induced...